Showing 1-10 of 10 for: Essential Evidence Topics > Poisoning and overdose 
- Acetaminophen toxicity
Essential Evidence Topics, 28-Sep-2022
Overall Bottom Line: Address basic life support first, and then obtain an accurate history of quantity, timing, type of ingestion and concomitant ingestions. If within 4 hours of ingestion give activated charcoal. Obtain a stat acetaminophen level and
- Amphetamine toxicity
Essential Evidence Topics, 3-Jul-2022
Bottom Line: The most used amphetamines are MDMA (methylenedioxymethamphetamine, "Ecstasy," "Adam"), MDA (3,4-methylenedioxyamphetamine, tenamfetamine, "Eve"), and recently PMA (paramethoxyamphetamine). Amphetamine overdose can range from agitation and eu
- Barbiturate toxicity
Essential Evidence Topics, 6-Jul-2022
Bottom-line: Obtain objective proof, when possible, of the time, quantity, and amount of the ingested product. Treatment is supportive. Ipecac or cathartic treatment should not be used; activated charcoal may prevent further absorption of ingested phe
- Benzodiazepine toxicity
Essential Evidence Topics, 4-Jan-2023
BOTTOM LINE: Clinical presentation generally consists of CNS depression, drowsiness, slurred speech, nystagmus, coma, respiratory depression, and hypotension. Address the ABCs (airway, breathing, circulation). Do not give ipecac or activated charcoal wi
- Digoxin toxicity
Essential Evidence Topics, 17-Jun-2021
Bottom-line: Suspect digoxin toxicity in patients taking digoxin who present with GI symptoms, visual changes, lethargy, confusion, weakness, or characteristic ECG changes (). Initial assessment should include digoxin level, potassium, and ECG. Monitor re
- Ethylene glycol poisoning
Essential Evidence Topics, 1-Mar-2021
Overall Bottom Line: Ethylene glycol toxicity should be suspected in patients presenting with altered mental status and possible/unknown substance ingestion. Diagnostic laboratory tests should include arterial blood gases, serum chemistries, anion gap,
- Iron toxicity
Essential Evidence Topics, 31-Dec-2021
OVERALL BOTTOM LINE: Most management recommendations are based on case reports, case series, or expert opinion. Children or adults ingesting less than 40 mg/kg can be observed at home. Experts recommend determining the amount of elemental iron ingeste
- Poisoning and toxicity (general approach)
Essential Evidence Topics, 30-Jan-2022
BOTTOM LINE: The American Association of Poison Control Centers (AAPCC) has documented over 2 million toxic exposures annually for the past 10 years. Intentional exposures accounted for only 8% of the total exposures, but were responsible for 80% to 90% o
- Reye's syndrome
Essential Evidence Topics, 29-Nov-2021
Overall Bottom Line: Reye's syndrome is now an uncommon diagnosis; disorders that can present with similar clinical features (such as disorders of fatty acid oxidation or urea cycle defects) are now far more common. Transfer to a pediatric intensive car
- Tricyclic antidepressant toxicity
Essential Evidence Topics, 9-Aug-2020
Overall Bottom Line: Cardinal symptoms of toxicity are hypotension, dysrhythmias, seizures, altered mental status, and coma. Serum levels of tricyclic antidepressants (TCAs) do not correlate with symptoms of toxicity or prognosis. Predictors of compli
