- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Vaccines against all stages of the malaria parasite are in development, mainly for Plasmodium falciparum, which causes the most serious form of malaria. Pre-erythrocytic vaccines act to prevent or delay a malaria attack by attacking the sporozoite and liv - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
A malaria vaccine is needed because of the heavy burden of mortality and morbidity due to this disease. This review describes the results of trials of blood (asexual)-stage vaccines. Several are under development, but only one (MSP/RESA, also known as Com - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Human African trypanosomiasis, or sleeping sickness, is a painful and protracted disease affecting people in the poorest parts of Africa and is fatal without treatment. Few drugs are currently available for second-stage sleeping sickness, with considerabl - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
With the increased demand for whiter teeth, home-based bleaching products, either dentist-prescribed or over-the-counter products have been exponentially increasing in the past few decades. This is an update of a Cochrane Review first published in 2006. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The clinical presentation of acute chest syndrome is similar whether due to infectious or non-infectious causes, thus antibiotics are usually prescribed to treat all episodes. Many different pathogens, including bacteria, have been implicated as causative - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Sickle cell disease is one of the most common genetic disorders. Sickle cell crises in which irregular and dehydrated cells contribute to blocking of blood vessels are characterised by episodes of pain. Treatment is mainly supportive and symptomatic. In v - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Cystic fibrosis is the most common autosomal recessive disease in white populations, and causes respiratory dysfunction in the majority of individuals. Numerous types of respiratory muscle training to improve respiratory function and health-related qualit - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Painful Bladder Syndrome/Interstitial Cystitis (PBS/IC) occurs predominantly in women. It is a poorly-understood condition with symptoms of bladder pain, urinary frequency, urgency and nocturia. Treatments for PBS/IC include dietary/lifestyle intervention - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
This systematic review update summarizes the current evidence on the use of natalizumab for induction of remission in Crohn's disease (CD). - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Problems with memory which do not meet the diagnostic criteria for dementia, usually called mild cognitive impairment (MCI), can be the first sign of an impending dementia, particularly Alzheimer's disease (AD). There is no consensus on a definition or di - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The use of insulin-sensitising agents, such as metformin, in women with polycystic ovary syndrome (PCOS) who are undergoing ovulation induction or in vitro fertilisation (IVF) cycles has been widely studied. Metformin reduces hyperinsulinaemia and suppres - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Hysterosalpingography (HSG) is a method of testing for tubal patency. However, women struggle to tolerate the procedure, as it is associated with some discomfort. Various pharmacological strategies are available that may reduce pain during the procedure, - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Many women undergoing an assisted reproductive technology (ART) cycle will not achieve a live birth. Failure at the embryo transfer stage may be due to lack of good-quality embryo/s, lack of uterine receptivity, or the transfer technique itself. Numerous - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Evidence suggests that many perimenopausal and early postmenopausal women will experience menopausal symptoms; hot flushes are the most common. Symptoms caused by fluctuating levels of oestrogen may be alleviated by hormone therapy (HT), but a marked glob - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Delirium is a common mental disorder, which is distressing and has serious adverse outcomes in hospitalised patients. Prevention of delirium is desirable from the perspective of patients and carers, and healthcare providers. It is currently unclear, howev - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Using a pilot system we have categorised this review as: Current question - no update intended (topic covered in another review. Refer to: Sinclair D, Zani B, Donegan S, Olliaro P, Garner P. Artemisinin-based combination therapy for treating uncomplicated - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Corticosteroids are commonly used in treatment of acute and chronic graft-versus-host disease (GvHD). Nevertheless, there has been no systematic analysis of effects of their use on the patients' survival and quality of life. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Dependence on car use has a number of broad health implications, including contributing to physical inactivity, road traffic injury, air pollution and social severance, as well as entrenching lifestyles that require environmentally unsustainable energy us - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Fluid excess may place people undergoing surgery at risk for various complications. Hypertonic salt solution (HS) maintains intravascular volume with less intravenous fluid than isotonic salt (IS) solutions, but may increase serum sodium. This review was - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Ulcerative colitis is an inflammatory condition affecting the colon, with an annual incidence of approximately 10 to 20 per 100,000 people. The majority of people with ulcerative colitis can be put into remission, leaving a group who do not respond to fir
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