- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Some studies have suggested that oxcarbazepine has a role in preventing episode recurrence in bipolar affective disorder. This review attempted to investigate the existing evidence from randomised controlled trials for its use in the maintenance treatment - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Persistent pulmonary hypertension in the neonate (PPHN) is associated with high mortality. Currently, the therapeutic mainstay for PPHN consists of assisted ventilation and administration of inhaled nitric oxide (iNO). However, nitric oxide is costly, and - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Cannabis use disorder is the most commonly reported illegal substance use disorder in the general population; although demand for assistance from health services is increasing internationally, only a minority of those with the disorder seek professional a - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Acid etching of tooth surfaces to promote the bonding of orthodontic attachments to the enamel has been a routine procedure in orthodontic treatment since the 1960s. Various types of orthodontic etchants and etching techniques have been introduced in the - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Clinical practice guidelines regarding the use of high-flux haemodialysis membranes vary widely. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The consequences of influenza in the elderly (those age 65 years or older) are complications, hospitalisations, and death. The primary goal of influenza vaccination in the elderly is to reduce the risk of death among people who are most vulnerable. This i - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia. Darbepoetin (Darbe) and EPO are currently available ESAs. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
People with end-stage kidney disease (ESKD) treated with dialysis are frequently affected by major depression. Dialysis patients have prioritised depression as a critically important clinical outcome in nephrology trials. Psychological and social support - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Pre-eclampsia is associated with deficient intravascular production of prostacyclin, a vasodilator, and excessive production of thromboxane, a vasoconstrictor and stimulant of platelet aggregation. These observations led to the hypotheses that antiplatele - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, autoimmune disease that results in joint deformity and immobility of the musculoskeletal system. The major goals of treatment are to relieve pain, reduce inflammation, slow down or stop joint - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Cerebral palsy (CP) is the most common cause of physical disabilities in children in high-income countries. Spasticity is the most common motor disturbance in CP. Botulinum toxin type A (BoNT-A) is considered the first-line treatment for focal spasticity - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The majority of people with epilepsy have a good prognosis and their seizures are controlled by a single antiepileptic drug. However, up to 20% of patients from population-based studies, and up to 30% from clinical series (not population-based), develop d - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Mortality from sepsis and septic shock remains high. Results of trials on intravenous immunoglobulins (IVIG) as adjunctive therapy for sepsis have been conflicting. This is an update of a Cochrane review that was originally published in 1999 and updated i - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Mechanical methods were the first methods developed to ripen the cervix and induce labour. During recent decades they have been substituted by pharmacological methods. Potential advantages of mechanical methods, compared with pharmacological methods may i - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Neonates are at higher risk of infection due to immuno-incompetence. Maternal transport of immunoglobulins to the fetus mainly occurs after 32 weeks' gestation, and endogenous synthesis begins several months after birth. Administration of intravenous immu - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Abnormal biliary secretion leads to the thickening of bile and the formation of plugs within the bile ducts; the consequent obstruction and abnormal bile flow ultimately results in the development of cystic fibrosis-related liver disease. This condition p - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
It has been argued that infants in Neonatal Intensive Care Units are subject both to a highly stressful environment - continuous, high-intensity noise and bright light - and to a lack of the tactile stimulation that they would otherwise experience in the - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Since pulmonary artery balloon flotation catheterization was first introduced in 1970, by HJ Swan and W Ganz, it has been widely disseminated as a diagnostic tool without rigorous evaluation of its clinical utility and effectiveness in critically ill pati - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Elevated plasma levels of the amino acid homocysteine (hyperhomocysteinaemia) are associated with narrowing or blocking of the arteries (atherosclerosis). Treatment to lower homocysteine levels has been shown to be both effective and cheap in healthy volu - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a disease that causes progressive or relapsing and remitting weakness and numbness. It is probably caused by an autoimmune process. Immunosuppressive or immunomodulatory drugs would be ex
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