- Combined DTP‐HBV‐HIB vaccine versus separately administered DTP‐HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB)
Cochrane Systematic Reviews, 18-Apr-2012
Advantages to combining childhood vaccines include reducing the number of visits, injections and patient discomfort, increasing compliance and optimising prevention. The World Health Organization (WHO) recommends that routine infant immunisation programme - Combined hormonal contraceptives for heavy menstrual bleeding
Cochrane Systematic Reviews, 11-Feb-2019
Menorrhagia or heavy menstrual bleeding (HMB) is an excessive blood loss that impairs a woman's quality of life, either physical, emotional, social or material. It is benign and not associated with pregnancy or any other gynaecological or systemic disease - Combined hormonal versus nonhormonal versus progestin-only contraception in lactation
Cochrane Systematic Reviews, 6-Mar-2015
Postpartum contraception improves the health of mothers and children by lengthening birth intervals. For lactating women, contraception choices are limited by concerns about hormonal effects on milk quality and quantity and passage of hormones to the infa - Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children
Cochrane Systematic Reviews, 4-Sep-2013
There are several treatment options for managing acute asthma exacerbations (sustained worsening of symptoms that do not subside with regular treatment and require a change in management). Guidelines advocate the use of inhaled short acting beta2-agonists - Combined inhaled beta‐agonist and anticholinergic agents for emergency management in adults with asthma
Cochrane Systematic Reviews, 11-Jan-2017
Inhaled short-acting anticholinergics (SAAC) and short-acting beta2-agonists (SABA) are effective therapies for adult patients with acute asthma who present to the emergency department (ED). It is unclear, however, whether the combination of SAAC and SABA - Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism
Cochrane Systematic Reviews, 28-Jan-2022
It is generally assumed by practitioners and guideline authors that combined modalities (methods of treatment) are more effective than single modalities in preventing venous thromboembolism (VTE), defined as deep vein thrombosis (DVT) or pulmonary embolis - Combined oestrogen and progesterone for preventing miscarriage
Cochrane Systematic Reviews, 23-Sep-2013
Historically, oestrogen and progesterone were each commonly used to save threatened pregnancies. In the 1940s it was postulated that their combined use would be synergistic and thereby led to the rationale of combined therapy for women who risked miscarri - Combined oral contraceptive pills for treatment of acne
Cochrane Systematic Reviews, 11-Jul-2012
Acne is a common skin disorder among women. Although no uniform approach to the management of acne exists, combination oral contraceptives (COCs), which contain an estrogen and a progestin, often are prescribed for women. - Combined oral contraceptives: the risk of myocardial infarction and ischemic stroke
Cochrane Systematic Reviews, 27-Aug-2015
Combined oral contraceptives (COCs) have been associated with an increased risk of arterial thrombosis, i.e. myocardial infarction or ischemic stroke. However, as these diseases are rare in young women and as many types of combined oral contraception exis - Combined oral contraceptives: venous thrombosis
Cochrane Systematic Reviews, 24-Feb-2014
Combined oral contraceptive (COC) use has been associated with venous thrombosis (VT) (i.e., deep venous thrombosis and pulmonary embolism). The VT risk has been evaluated for many estrogen doses and progestagen types contained in COC but no comprehensive - Combined pharmacotherapy and behavioural interventions for smoking cessation
Cochrane Systematic Reviews, 22-Mar-2016
Both behavioural support (including brief advice and counselling) and pharmacotherapies (including nicotine replacement therapy (NRT), varenicline and bupropion) are effective in helping people to stop smoking. Combining both treatment approaches is recom - Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD)
Cochrane Systematic Reviews, 16-Jun-2010
PTSD is an anxiety disorder related to exposure to a severe psychological trauma. Symptoms include re-experiencing the event, avoidance and arousal as well as distress and impairment resulting from these symptoms. - Combined proximal descending aortic endografting plus distal bare metal stenting (PETTICOAT technique) versus conventional proximal descending aortic stent graft repair for complicated type B aortic dissections
Cochrane Systematic Reviews, 30-Oct-2019
Aortic dissection is a separation of the aortic wall, caused by blood flowing through a tear in the inner layer of the aorta. Aortic dissection is an infrequent but life-threatening condition. The incidence of aortic dissection is 3 to 6 per 10,000 per ye - Combined psychotherapy plus antidepressants for panic disorder with or without agoraphobia
Cochrane Systematic Reviews, 31-Oct-2008
Panic disorder can be treated with pharmacotherapy, psychotherapy or in combination, but the relative merits of combined therapy have not been well established. - Combined psychotherapy plus benzodiazepines for panic disorder
Cochrane Systematic Reviews, 21-Jan-2009
The efficacy of combining psychotherapy and benzodiazepines for panic disorder is unclear, despite widespread use. - Combined spinal‐epidural versus epidural analgesia in labour
Cochrane Systematic Reviews, 17-Oct-2012
Traditional epidural techniques have been associated with prolonged labour, use of oxytocin augmentation and increased incidence of instrumental vaginal delivery. The combined spinal-epidural (CSE) technique has been introduced in an attempt to reduce the - Combined spinal‐epidural versus spinal anaesthesia for caesarean section
Cochrane Systematic Reviews, 10-Oct-2019
Single-shot spinal anaesthesia (SSS) and combined spinal-epidural (CSE) anaesthesia are both commonly used for caesarean section anaesthesia. Spinals offer technical simplicity and rapid onset of nerve blockade which can be associated with hypotension. CS - Combined surgery versus cataract surgery alone for eyes with cataract and glaucoma
Cochrane Systematic Reviews, 14-Jul-2015
Cataract and glaucoma are leading causes of blindness worldwide, and their co-existence is common in elderly people. Glaucoma surgery can accelerate cataract progression, and performing both surgeries may increase the rate of postoperative complications a - Combined use of hyperthermia and (chemo)radiation therapy for treating locally advanced cervix carcinoma
Cochrane Systematic Reviews, 17-Mar-2010
Hyperthermia is a type of cancer treatment in which body tissue is exposed to high temperatures to damage and kill cancer cells. It was introduced into clinical oncology practice several decades ago. Positive clinical results, mostly obtained in single in - Combined vitamin B6‐magnesium treatment in autism spectrum disorder
Cochrane Systematic Reviews, 19-Oct-2005
The use of mega-vitamin intervention began in the 1950s with the treatment of schizophrenic patients. Pyroxidine (vitamin B6) was first used with children diagnosed with "autism syndrome" when speech and language improvement was observed in some children
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