- Combination pharmacotherapy for the treatment of fibromyalgia in adults
Cochrane Systematic Reviews, 19-Feb-2018
Fibromyalgia is a chronic widespread pain condition affecting millions of people worldwide. Current pharmacotherapies are often ineffective and poorly tolerated. Combining different agents could provide superior pain relief and possibly also fewer side ef - Combination pharmacotherapy for the treatment of neuropathic pain in adults
Cochrane Systematic Reviews, 11-Jul-2012
Pharmacotherapy remains an important modality for the treatment of neuropathic pain. However, as monotherapy current drugs are associated with limited efficacy and dose-related side effects. Combining two or more different drugs may improve analgesic effi - Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Cochrane Systematic Reviews, 25-Aug-2011
Despite optimal therapy with disease-modifying antirheumatic drugs, many people with inflammatory arthritis (IA) continue to have persistent pain that may require additional therapy. - Combination versus sequential single agent chemotherapy for metastatic breast cancer
Cochrane Systematic Reviews, 18-Dec-2013
Combination chemotherapy can cause greater tumour cell kill if the drug dose is not compromised, while sequential single agent chemotherapy may allow for greater dose intensity and treatment time, potentially meaning greater benefit from each single agent - Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for preventing dental caries in children and adolescents
Cochrane Systematic Reviews, 26-Jan-2004
Topical fluoride therapy (TFT) in the form of toothpastes, mouthrinses, varnishes and gels are effective caries preventive measures. However, there is uncertainty about the relative value of these interventions when used together. - Combined aclidinium bromide and long‐acting beta2‐agonist for chronic obstructive pulmonary disease (COPD)
Cochrane Systematic Reviews, 11-Dec-2018
Several dual bronchodilator combinations of long-acting beta2-agonist (LABA) and long-acting muscarinic antagonist (LAMA) have been approved for treatment of stable chronic obstructive pulmonary disease (COPD). The current GOLD (Global Initiative for Chro - Combined and alternating paracetamol and ibuprofen therapy for febrile children
Cochrane Systematic Reviews, 28-Oct-2013
Health professionals frequently recommend fever treatment regimens for children that either combine paracetamol and ibuprofen or alternate them. However, there is uncertainty about whether these regimens are better than the use of single agents, and about - Combined calcium, magnesium and potassium supplementation for the management of primary hypertension in adults
Cochrane Systematic Reviews, 19-Jul-2006
Previous research suggests that increasing dietary intakes of calcium, potassium or magnesium separately may reduce BP to a small degree over the short term. It is unclear whether increasing intakes of a combination of these minerals produces a larger red - Combined chiropractic interventions for low‐back pain
Cochrane Systematic Reviews, 14-Apr-2010
Chiropractors commonly use a combination of interventions to treat people with low-back pain (LBP). - Combined corticosteroid and long‐acting beta2‐agonist in one inhaler versus inhaled corticosteroids alone for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 30-Aug-2013
Both long-acting beta2-agonists and inhaled corticosteroids have been recommended in guidelines for the treatment of chronic obstructive pulmonary disease (COPD). Their co-administration in a combined inhaler is intended to facilitate adherence to medicat - Combined corticosteroid and long-acting beta2-agonist in one inhaler versus long-acting beta2-agonists for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 12-Apr-2013
Both inhaled steroids (ICS) and long-acting beta2-agonists (LABA) are used in the management of chronic obstructive pulmonary disease (COPD). This updated review compared compound LABA plus ICS therapy (LABA/ICS) with the LABA component drug given alone. - Combined corticosteroid and long‐acting beta2‐agonist in one inhaler versus placebo for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 10-Nov-2013
Both long-acting beta2-agonists (LABA) and inhaled corticosteroids (ICS) have been recommended in guidelines for the treatment of chronic obstructive pulmonary disease (COPD). Their coadministration in a combination inhaler may facilitate adherence to med - Combined diet and exercise interventions for preventing gestational diabetes mellitus
Cochrane Systematic Reviews, 13-Nov-2017
Gestational diabetes mellitus (GDM) is associated with a wide range of adverse health consequences for women and their infants in the short and long term. With an increasing prevalence of GDM worldwide, there is an urgent need to assess strategies for GDM - Combined DTP‐HBV‐HIB vaccine versus separately administered DTP‐HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB)
Cochrane Systematic Reviews, 18-Apr-2012
Advantages to combining childhood vaccines include reducing the number of visits, injections and patient discomfort, increasing compliance and optimising prevention. The World Health Organization (WHO) recommends that routine infant immunisation programme - Combined hormonal contraceptives for heavy menstrual bleeding
Cochrane Systematic Reviews, 11-Feb-2019
Menorrhagia or heavy menstrual bleeding (HMB) is an excessive blood loss that impairs a woman's quality of life, either physical, emotional, social or material. It is benign and not associated with pregnancy or any other gynaecological or systemic disease - Combined hormonal versus nonhormonal versus progestin-only contraception in lactation
Cochrane Systematic Reviews, 6-Mar-2015
Postpartum contraception improves the health of mothers and children by lengthening birth intervals. For lactating women, contraception choices are limited by concerns about hormonal effects on milk quality and quantity and passage of hormones to the infa - Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children
Cochrane Systematic Reviews, 4-Sep-2013
There are several treatment options for managing acute asthma exacerbations (sustained worsening of symptoms that do not subside with regular treatment and require a change in management). Guidelines advocate the use of inhaled short acting beta2-agonists - Combined inhaled beta‐agonist and anticholinergic agents for emergency management in adults with asthma
Cochrane Systematic Reviews, 11-Jan-2017
Inhaled short-acting anticholinergics (SAAC) and short-acting beta2-agonists (SABA) are effective therapies for adult patients with acute asthma who present to the emergency department (ED). It is unclear, however, whether the combination of SAAC and SABA - Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism
Cochrane Systematic Reviews, 28-Jan-2022
It is generally assumed by practitioners and guideline authors that combined modalities (methods of treatment) are more effective than single modalities in preventing venous thromboembolism (VTE), defined as deep vein thrombosis (DVT) or pulmonary embolis - Combined oestrogen and progesterone for preventing miscarriage
Cochrane Systematic Reviews, 23-Sep-2013
Historically, oestrogen and progesterone were each commonly used to save threatened pregnancies. In the 1940s it was postulated that their combined use would be synergistic and thereby led to the rationale of combined therapy for women who risked miscarri
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