- Closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack
Cochrane Systematic Reviews, 26-Aug-2015
The optimal therapy for preventing recurrent stroke in people with cryptogenic stroke and patent foramen ovale (PFO) has not been defined. The choice between medical therapy (antithrombotic treatment with antiplatelet agents or anticoagulants) and transca - Closure versus non-closure of the peritoneum at caesarean section: short- and long-term outcomes
Cochrane Systematic Reviews, 7-Aug-2014
Caesarean section is a very common surgical procedure worldwide. Suturing the peritoneal layers at caesarean section may or may not confer benefit, hence the need to evaluate whether this step should be omitted or routinely performed. - Clotiapine for acute psychotic illnesses
Cochrane Systematic Reviews, 25-Jul-2012
Acute psychotic illnesses, especially when associated with agitated or violent behaviour, require urgent pharmacological tranquillisation or sedation. Clotiapine, a dibenzothiazepine neuroleptic, is being used for this purpose in several countries. - Clotting factor concentrates for preventing bleeding and bleeding‐related complications in previously treated individuals with haemophilia A or B
Cochrane Systematic Reviews,
The hallmark of severe hemophilia (A or B) is recurrent bleeding into joints and soft tissues with progressive joint damage, despite on-demand treatment. Prophylaxis has long been used, but not universally adopted, because of medical, psychosocial, and co - Clotting factor concentrates given to prevent bleeding and bleeding-related complications in people with hemophilia A or B
Cochrane Systematic Reviews, 19-Jul-2011
The hallmark of severe hemophilia is recurrent bleeding into joints and soft tissues with progressive joint damage, notwithstanding on-demand treatment. Prophylaxis has long been used but not universally adopted because of medical, psychosocial, and cost - Clozapine combined with different antipsychotic drugs for treatment‐resistant schizophrenia
Cochrane Systematic Reviews, 23-Mar-2017
Between 40% and 70% of people with treatment-resistant schizophrenia do not respond to clozapine, despite adequate blood levels. For these people, a number of treatment strategies have emerged, including the prescription of a second anti-psychotic drug in - Clozapine dose for schizophrenia
Cochrane Systematic Reviews, 13-Jun-2017
Schizophrenia and related disorders such as schizophreniform and schizoaffective disorder are serious mental illnesses characterised by profound disruptions in thinking and speech, emotional processes, behaviour and sense of self. Clozapine is useful in t - Clozapine for psychotic disorders in adults with intellectual disabilities
Cochrane Systematic Reviews, 23-Sep-2015
Psychosis is three times more common in people with an intellectual disability than in those without an intellectual disability. A low intelligence quotient (IQ) is a defining characteristic for intellectual disability and a risk factor for poor outcome i - Clozapine versus other atypical antipsychotics for schizophrenia
Cochrane Systematic Reviews, 9-Nov-2010
Clozapine is an atypical antipsychotic demonstrated to be superior in the treatment of refractory schizophrenia which causes fewer movement disorders. Clozapine, however, entails a significant risk of serious blood disorders such as agranulocytosis which - Clozapine versus typical neuroleptic medication for schizophrenia
Cochrane Systematic Reviews, 10-Nov-2009
Long-term drug treatment of schizophrenia with typical antipsychotic drugs has limitations: 25 to 33% of sufferers have illnesses that are treatment resistant. Clozapine is an antipsychotic drug, which is claimed to have superior efficacy and to cause few - Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome
Cochrane Systematic Reviews, 13-Jun-2017
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic and potentially life threatening condition resulting from excessive ovarian stimulation. Reported incidence of moderate to severe OHSS ranges from 0.6% to 5% of in vitro fertilization (IVF) cycles. - Co‐bedding in neonatal nursery for promoting growth and neurodevelopment in stable preterm twins
Cochrane Systematic Reviews, 6-Feb-2017
The increased birth rate of twins during recent decades and the improved prognosis of preterm infants have resulted in the need to explore measures that could optimize their growth and neurodevelopmental outcomes. It has been postulated that co-bedding si - Coblation versus other surgical techniques for tonsillectomy
Cochrane Systematic Reviews, 17-Aug-2017
Tonsillectomy is a very common operation and is performed using various surgical methods. Coblation is a popular method because it purportedly causes less pain than other surgical methods. However, the superiority of coblation is unproven. - Codeine versus placebo for chronic cough in children
Cochrane Systematic Reviews, 11-Jul-2016
Cough in children is a commonly experienced symptom that is associated with increased health service utilisation and burden to parents. The presence of chronic (equal to or more than four weeks) cough in children may indicate a serious underlying conditio - Coenzyme Q10 for heart failure
Cochrane Systematic Reviews,
Coenzyme Q10, or ubiquinone, is a non-prescription nutritional supplement. It is a fat-soluble molecule that acts as an electron carrier in mitochondria, and as a coenzyme for mitochondrial enzymes. Coenzyme Q10 deficiency may be associated with a multitu - Coenzyme Q10 for Parkinson's disease
Cochrane Systematic Reviews, 16-Apr-2012
A number of preclinical studies in both in vitro and in vivo models of Parkinson's disease have demonstrated that coenzyme Q10 can protect the nigrostriatal dopaminergic system. Some clinical trials have looked at the neuroprotective effects of coenzyme Q - Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease
Cochrane Systematic Reviews, 2-Dec-2014
Cardiovascular disease (CVD) remains the number one cause of death and disability worldwide and public health interventions focus on modifiable risk factors, such as diet. Coenzyme Q10 (CoQ10) is an antioxidant that is naturally synthesised by the body an - Co‐formulated abacavir‐lamivudine‐zidovudine for initial treatment of HIV infection and AIDS
Cochrane Systematic Reviews, 18-Mar-2016
UNAIDS estimates that 34 million people are currently living with the human immunodeficiency virus (HIV) worldwide. Currently recommended regimens for initiating HIV treatment consist of either a non-nucleoside reverse transcriptase inhibitor (NNRTI) or r - Cognition-based interventions for healthy older people and people with mild cognitive impairment
Cochrane Systematic Reviews, 7-Dec-2010
Evidence from some, but not all non-randomised studies suggest the possibility that cognitive training may influence cognitive functioning in older people. Due to the differences among cognitive training interventions reported in the literature, giving a - Cognitive behaviour therapy for chronic fatigue syndrome in adults
Cochrane Systematic Reviews,
Chronic fatigue syndrome (CFS) is a common, debilitating and serious health problem. Cognitive behaviour therapy (CBT) may help to alleviate the symptoms of CFS.
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