- Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults
Cochrane Systematic Reviews, 19-Nov-2013
The early detection and excision of potentially malignant disorders (PMD) of the lip and oral cavity that require intervention may reduce malignant transformations (though will not totally eliminate malignancy occurring), or if malignancy is detected duri - Clinical decision support systems for neonatal care
Cochrane Systematic Reviews, 12-Feb-2009
Clinical decision support systems (CDSS) are computer-based information systems used to integrate clinical and patient information to provide support for decision-making in patient care. They may be useful in aiding the diagnostic process, the generation - Clinical pathways for chronic cough in children
Cochrane Systematic Reviews, 5-Sep-2014
Chronic cough (a cough lasting longer than four weeks) is a common problem internationally. Chronic cough has associated economic costs and is distressing to the child and to parents; ignoring cough may lead to delayed diagnosis and progression of serious - Clinical pathways: effects on professional practice, patient outcomes, length of stay and hospital costs
Cochrane Systematic Reviews, 15-Jun-2010
Clinical pathways are structured multidisciplinary care plans used by health services to detail essential steps in the care of patients with a specific clinical problem. They aim to link evidence to practice and optimise clinical outcomes whilst maximisin - Clinical symptoms and signs for the diagnosis of Mycoplasma pneumoniae in children and adolescents with community‐acquired pneumonia
Cochrane Systematic Reviews, 20-Aug-2012
Mycoplasma pneumoniae (M. pneumoniae) is a significant cause of community-acquired pneumonia in children and adolescents. Treatment with macrolide antibiotics is recommended. However, M. pneumoniae is difficult to diagnose based on clinical symptoms and s - Clinical symptoms, signs and tests for identification of impending and current water‐loss dehydration in older people
Cochrane Systematic Reviews, 2-Jul-2015
There is evidence that water-loss dehydration is common in older people and associated with many causes of morbidity and mortality. However, it is unclear what clinical symptoms, signs and tests may be used to identify early dehydration in older people, s - Clinically‐indicated replacement versus routine replacement of peripheral venous catheters
Cochrane Systematic Reviews, 21-Jan-2019
US Centers for Disease Control guidelines recommend replacement of peripheral intravenous catheters (PIVC) no more frequently than every 72 to 96 hours. Routine replacement is thought to reduce the risk of phlebitis and bloodstream infection. Catheter ins - Clinician‐targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews
Cochrane Systematic Reviews, 11-Sep-2019
Antibiotic resistance is a worldwide health threat. Interventions that reduce antibiotic prescribing by clinicians are expected to reduce antibiotic resistance. Disparate interventions to change antibiotic prescribing behaviour for acute respiratory infec - Clobazam add‐on therapy for drug‐resistant epilepsy
Cochrane Systematic Reviews, 14-Oct-2019
Epilepsy affects approximately 1% of the population, with up to 30% of patients continuing to have seizures, despite antiepileptic drug treatment. Clobazam is a 1,5-benzodiazepine and is commonly used as an add-on treatment for drug-resistant epilepsy. Th - Clobazam monotherapy for focal or generalized seizures
Cochrane Systematic Reviews, 9-May-2018
This is an updated version of the original Cochrane Review published in Issue 10, 2014. There is a need to expand monotherapy options available to a clinician for the treatment of new focal or generalized seizures. A Cochrane systematic review for clobaza - Clofibrate in combination with phototherapy for unconjugated neonatal hyperbilirubinaemia
Cochrane Systematic Reviews, 20-Mar-2019
There are many pathological conditions leading to an elevated unconjugated bilirubin level (hyperbilirubinaemia) in neonates. Currently the standard therapies for unconjugated hyperbilirubinaemia include phototherapy and exchange transfusion. In addition - Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome
Cochrane Systematic Reviews, 11-Jan-2017
Subfertility due to anovulation is a common problem in women. First-line oral treatment is with antioestrogens such as clomiphene citrate, but resistance may be apparent with clomiphene. Alternative and adjunctive treatments have been used including tamox - Clomiphene citrate for ovulation induction in women with oligo-amenorrhoea
Cochrane Systematic Reviews, 17-Jul-2008
The administration of clomiphene citrate is followed by an enhanced release of pituitary gonadotropins resulting in follicular recruitment. After the drug is stopped, there is continuing secretion of estradiol, selection of the dominant follicle and, in s - Clomiphene citrate for unexplained subfertility in women
Cochrane Systematic Reviews, 5-Oct-2009
The effectiveness of clomiphene citrate has been demonstrated in the treatment of subfertility associated with infrequent or irregular ovulation. The physiologic effects and clinical benefits in ovulatory women with unexplained subfertility are less clear - Clomiphene or tamoxifen for idiopathic oligo/asthenospermia
Cochrane Systematic Reviews, 17-Jul-2008
Oligo-astheno-teratospermia (sperm of low concentration, reduced motility and increased abnormal morphology) of unknown cause is common and the need for treatment is felt by patients and doctors alike. As a result, a variety of empirical, non-specific tre - Clonazepam add‐on therapy for drug‐resistant epilepsy
Cochrane Systematic Reviews, 16-Apr-2020
This is an updated version of the original Cochrane Review published in 2018, Issue 5. - Clonazepam for neuropathic pain and fibromyalgia in adults
Cochrane Systematic Reviews, 29-May-2019
Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Clonazepam, a benzodiazepine, is an established antiepileptic drug, but its place in the treatment of neurop - Clonazepam monotherapy for treating people with newly diagnosed epilepsy
Cochrane Systematic Reviews, 14-Nov-2019
Epilepsy is one of the most common neurological disorders worldwide, with an age-adjusted prevalence of 4 to 8 per 1000 population and an age-adjusted incidence of 44 per 100,000 person-years in developed countries. Monotherapy represents the best therape - Clonidine for pain in non‐ventilated infants
Cochrane Systematic Reviews, 21-Apr-2020
Critically ill newborn infants undergo a variety of painful procedures or experience a variety of painful conditions during their early life in the neonatal unit. In the critically ill paediatric and neonatal population, clonidine is prescribed as an adju - Clonidine for sedation and analgesia for neonates receiving mechanical ventilation
Cochrane Systematic Reviews, 10-May-2017
Although routine administration of pharmacologic sedation or analgesia during mechanical ventilation in preterm neonates is not recommended, its use in clinical practice remains common. Alpha-2 agonists, mainly clonidine and dexmedetomidine, are used as a
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