- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Glutamate is the principal excitatory neurotransmitter in the brain. Injury to the brain can cause an ionic imbalance in cerebral tissue, creating an excitotoxic cascade involving glutamate and other excitatory amino acids, that leads to neuronal death in - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Excessive drinking is a significant cause of mortality, morbidity and social problems in many countries. Brief interventions aim to reduce alcohol consumption and related harm in hazardous and harmful drinkers who are not actively seeking help for alcohol - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Unilateral cerebral palsy (CP) is a condition that affects muscle control and function on one side of the body. Children with unilateral CP experience difficulties using their hands together secondary to disturbances that occur in the developing fetal or - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Some dental implant failures may be due to bacterial contamination at implant insertion. Infections around biomaterials are difficult to treat, and almost all infected implants have to be removed. In general, antibiotic prophylaxis in surgery is only indi - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Epilepsy affects approximately 1% of the population, with up to 30% of patients continuing to have seizures, despite antiepileptic drug treatment. Clobazam is a 1,5-benzodiazepine and is commonly used as an add-on treatment for drug-resistant epilepsy. Th - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Use of pressure ulcer risk assessment tools or scales is a component of the assessment process used to identify individuals at risk of developing a pressure ulcer. Use of a risk assessment tool is recommended by many international pressure ulcer preventio - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Oral anticoagulants may improve the survival of people with cancer through both an antitumor effect and antithrombotic effect, yet increase the risk of bleeding. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Cancer increases the risk of thromboembolic events, especially in people receiving anticoagulation treatments. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Anticoagulation may improve survival in patients with cancer through a speculated anti-tumour effect, in addition to the antithrombotic effect, although may increase the risk of bleeding. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Very early mobilisation (VEM) is performed in some stroke units and recommended in some acute stroke clinical guidelines. However, it is unclear whether very early mobilisation independently improves outcome after stroke. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Chronic obstructive pulmonary disease (COPD) is a global leading cause of morbidity and mortality, characterised by acute deterioration in symptoms. During these exacerbations, people are prone to developing alveolar hypoventilation, which may be partly c - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Surgery has been used as part of breast cancer treatment for centuries; however any surgical procedure has the potential risk of infection. Infection rates for surgical treatment of breast cancer are documented at between 3% and 15%, higher than average f - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Epithelial ovarian cancer presents at an advanced stage in the majority of women. These women require surgery and chemotherapy for optimal treatment. Conventional treatment has been to perform surgery first and then give chemotherapy. However, there may b - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Paraproteinaemic neuropathy refers to those neuropathies associated with a monoclonal gammopathy or paraprotein. The most common of these present with a chronic, predominantly sensory, symmetrical neuropathy, similar to chronic inflammatory demyelinating - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Taking regular exercise, whether cardiovascular-type exercise or resistance exercise, may help people to give up smoking, particularly by reducing cigarette withdrawal symptoms and cravings, and by helping to manage weight gain. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Surfactant replacement therapy has been proven beneficial in the prevention and treatment of neonatal respiratory distress syndrome (RDS). The deficiency of surfactant or surfactant dysfunction may contribute to respiratory failure in a broader group of d - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Proper sedation for neonates undergoing uncomfortable procedures may reduce stress and avoid complications. Midazolam is a short-acting benzodiazepine that is used increasingly in neonatal intensive care units (NICUs). However, its effectiveness as a seda - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Pleural infection, including parapneumonic effusions and thoracic empyema, may complicate lower respiratory tract infections. Standard treatment of these collections in adults involves antibiotic therapy, effective drainage of infected fluid and surgical - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
It is important to institute an effective supportive therapy to maintain or recover soft tissue health around dental implants. Different maintenance regimens have been suggested, however it is unclear which are the most effective. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop into a substantial health problem worldwide. Whether diet, physical activity or both can prevent or delay T2DM and its associated complications in at-risk people is unkno
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