- Chemotherapy for advanced non‐small cell lung cancer in the elderly population
Cochrane Systematic Reviews, 20-Oct-2015
Approximately 50% of patients with newly diagnosed non-small cell lung cancer (NSCLC) are over 70 years of age at diagnosis. Despite this fact, these patients are underrepresented in randomized controlled trials (RCTs). As a consequence, the most appropri - Chemotherapy for advanced ovarian cancer
Cochrane Systematic Reviews, 21-Feb-2011
Ovarian carcinoma is the seventh commonest female cancer worldwide and is responsible for the greatest number of deaths from gynaecological malignancy in Europe and North America. Although many studies have explored the use of chemotherapy in this disease - Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma
Cochrane Systematic Reviews, 15-Aug-2012
Although endometrial adenocarcinoma is a common gynaecological cancer, a comparatively small proportion of patients present with, or develop, recurrent or advanced disease. However, for those women whose disease does progress or recur the prognosis is poo - Chemotherapy for brain metastases from small cell lung cancer
Cochrane Systematic Reviews, 11-May-2012
Small cell lung cancer (SCLC) accounts for approximately 20% of all cases of lung cancer. It tends to disseminate early in the course of its natural history and to grow quickly. Approximately 10% to 18% of patients present with brain metastases (BM) at th - Chemotherapy for children with medulloblastoma
Cochrane Systematic Reviews, 18-Dec-2014
Post-surgical radiotherapy (RT) in combination with chemotherapy is considered as standard of care for medulloblastoma in children. Chemotherapy has been introduced to improve survival and to reduce RT-induced adverse effects. Reduction of RT-induced adve - Chemotherapy for high-grade glioma
Cochrane Systematic Reviews, 27-Mar-2014
Trials on the effect of systemic chemotherapy on survival and recurrence in adults with high-grade glioma have had inconclusive results. We undertook a systematic review and meta-analysis to assess the effects of such treatment on survival and recurrence. - Chemotherapy for hormone-refractory prostate cancer
Cochrane Systematic Reviews, 2-Jun-2008
Prostate cancer mainly affects elderly men, and its incidence has steadily increased over the last decade. The management of this disease is replete with controversy. In men with advanced, metastatic prostate cancer, hormone therapy is almost universally - Chemotherapy for malignant germ cell ovarian cancer in adult patients with early stage, advanced and recurrent disease
Cochrane Systematic Reviews, 16-Mar-2011
Malignant germ cell tumour of the ovary occurs in up to 0.07% of woman globally. Due to its rarity, evidence for treatment is lacking and often extrapolates clinical trial results of testicular germ cell cancers. The investigation on this rare tumour is f - Chemotherapy for metastatic and recurrent cervical cancer
Cochrane Systematic Reviews, 17-Oct-2012
Cervical cancer is the second most common cancer among women up to 65 years of age and is the most frequent cause of death from gynaecological cancers worldwide. A woman's risk of developing cervical cancer by 65 years of age ranges from 0.69% in develope - Chemotherapy for non-small cell lung cancer
Cochrane Systematic Reviews, 9-Mar-2015
The role of chemotherapy in the treatment of patients with non-small cell lung cancer was not clear. A systematic review and quantitative meta-analysis was therefore undertaken to evaluate the available evidence from all relevant randomised trials. - Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia
Cochrane Systematic Reviews, 13-Jan-2016
Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy-related tumours; however, approximately 25% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will requir - Chemotherapy for second‐stage Human African trypanosomiasis
Cochrane Systematic Reviews, 28-Jun-2013
Human African trypanosomiasis, or sleeping sickness, is a painful and protracted disease affecting people in the poorest parts of Africa and is fatal without treatment. Few drugs are currently available for second-stage sleeping sickness, with considerabl - Chemotherapy for second‐stage human African trypanosomiasis: drugs in use
Cochrane Systematic Reviews, 9-Dec-2021
Human African trypanosomiasis, or sleeping sickness, is a severe disease affecting people in the poorest parts of Africa. It is usually fatal without treatment. Conventional treatments require days of intravenous infusion, but a recently developed drug, f - Chemotherapy for thymic carcinoma and advanced thymoma in adults
Cochrane Systematic Reviews, 23-Aug-2013
Thymic carcinoma or advanced thymoma is a rare cancer of the thymus gland that tends to be aggressive and infiltrate neighbouring organs, making total resection very difficult. Induction or adjuvant chemotherapy, or both, are often used in a multimodality - Chemotherapy plus Rituximab versus chemotherapy alone for B-cell non-Hodgkin's lymphoma
Cochrane Systematic Reviews, 21-Aug-2008
Rituximab (R) has been shown to improve response rates and progression free survival when added to chemotherapy in patients with indolent and mantle cell lymphoma. However, the impact of R on overall survival (OS) when given in combination with chemothera - Chemotherapy versus best supportive care for extensive small cell lung cancer
Cochrane Systematic Reviews, 22-Nov-2013
Combination chemotherapy has been the mainstay of treatment for extensive stage small celI lung cancer (SCLC) over the last 30 years, even though it only gives a short prolongation in median survival time. The main goal for these patients should be pallia - Chemotherapy wafers for high grade glioma
Cochrane Systematic Reviews, 16-Mar-2011
Standard treatment for high grade glioma (HGG) usually entails surgery (either biopsy or resection) followed by radiotherapy plus or minus temozolomide. Implanting wafers impregnated with chemotherapy agents into the resection cavity represents a novel me - Chemotherapy with cetuximab versus chemotherapy alone for chemotherapy‐naive advanced non‐small cell lung cancer
Cochrane Systematic Reviews, 17-Nov-2014
In advanced non-small cell lung cancer (NSCLC), the effectiveness of standard cytotoxic chemotherapy seems to have reached a 'plateau', and there is a continuous need for new treatments to further improve the prognosis. Cetuximab is a monoclonal antibody - Chemotherapy, radiotherapy and combined modality for Hodgkin's disease, with emphasis on second cancer risk
Cochrane Systematic Reviews, 19-Oct-2005
Second malignancies (SM) are a major late effect of treatment for Hodgkin's disease (HD). Reliable comparisons of SM risk between alternative treatment strategies are lacking. - Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old
Cochrane Systematic Reviews, 3-Apr-2023
Acute bronchiolitis is the leading cause of medical emergencies during winter months in infants younger than 24 months old. Chest physiotherapy is sometimes used to assist infants in the clearance of secretions in order to decrease ventilatory effort. Thi
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