- Chemotherapy for children with medulloblastoma
Cochrane Systematic Reviews, 18-Dec-2014
Post-surgical radiotherapy (RT) in combination with chemotherapy is considered as standard of care for medulloblastoma in children. Chemotherapy has been introduced to improve survival and to reduce RT-induced adverse effects. Reduction of RT-induced adve - Chemotherapy for high‐grade glioma
Cochrane Systematic Reviews, 21-Oct-2002
Trials on the effect of systemic chemotherapy on survival and recurrence in adults with high-grade glioma have had inconclusive results. We undertook a systematic review and meta-analysis to assess the effects of such treatment on survival and recurrence. - Chemotherapy for hormone-refractory prostate cancer
Cochrane Systematic Reviews, 2-Jun-2008
Prostate cancer mainly affects elderly men, and its incidence has steadily increased over the last decade. The management of this disease is replete with controversy. In men with advanced, metastatic prostate cancer, hormone therapy is almost universally - Chemotherapy for malignant germ cell ovarian cancer in adult patients with early stage, advanced and recurrent disease
Cochrane Systematic Reviews, 16-Mar-2011
Malignant germ cell tumour of the ovary occurs in up to 0.07% of woman globally. Due to its rarity, evidence for treatment is lacking and often extrapolates clinical trial results of testicular germ cell cancers. The investigation on this rare tumour is f - Chemotherapy for metastatic and recurrent cervical cancer
Cochrane Systematic Reviews, 17-Oct-2012
Cervical cancer is the second most common cancer among women up to 65 years of age and is the most frequent cause of death from gynaecological cancers worldwide. A woman's risk of developing cervical cancer by 65 years of age ranges from 0.69% in develope - Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia
Cochrane Systematic Reviews, 13-Jan-2016
Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy-related tumours; however, approximately 25% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will requir - Chemotherapy for second‐stage Human African trypanosomiasis
Cochrane Systematic Reviews, 28-Jun-2013
Human African trypanosomiasis, or sleeping sickness, is a painful and protracted disease affecting people in the poorest parts of Africa and is fatal without treatment. Few drugs are currently available for second-stage sleeping sickness, with considerabl - Chemotherapy for second‐stage human African trypanosomiasis: drugs in use
Cochrane Systematic Reviews, 9-Dec-2021
Human African trypanosomiasis, or sleeping sickness, is a severe disease affecting people in the poorest parts of Africa. It is usually fatal without treatment. Conventional treatments require days of intravenous infusion, but a recently developed drug, f - Chemotherapy for thymic carcinoma and advanced thymoma in adults
Cochrane Systematic Reviews, 23-Aug-2013
Thymic carcinoma or advanced thymoma is a rare cancer of the thymus gland that tends to be aggressive and infiltrate neighbouring organs, making total resection very difficult. Induction or adjuvant chemotherapy, or both, are often used in a multimodality - Chemotherapy plus Rituximab versus chemotherapy alone for B‐cell non‐Hodgkin's lymphoma
Cochrane Systematic Reviews, 17-Oct-2007
Rituximab (R) has been shown to improve response rates and progression free survival when added to chemotherapy in patients with indolent and mantle cell lymphoma. However, the impact of R on overall survival (OS) when given in combination with chemothera - Chemotherapy versus best supportive care for extensive small cell lung cancer
Cochrane Systematic Reviews, 22-Nov-2013
Combination chemotherapy has been the mainstay of treatment for extensive stage small celI lung cancer (SCLC) over the last 30 years, even though it only gives a short prolongation in median survival time. The main goal for these patients should be pallia - Chemotherapy wafers for high grade glioma
Cochrane Systematic Reviews, 16-Mar-2011
Standard treatment for high grade glioma (HGG) usually entails surgery (either biopsy or resection) followed by radiotherapy plus or minus temozolomide. Implanting wafers impregnated with chemotherapy agents into the resection cavity represents a novel me - Chemotherapy with cetuximab versus chemotherapy alone for chemotherapy‐naive advanced non‐small cell lung cancer
Cochrane Systematic Reviews, 17-Nov-2014
In advanced non-small cell lung cancer (NSCLC), the effectiveness of standard cytotoxic chemotherapy seems to have reached a 'plateau', and there is a continuous need for new treatments to further improve the prognosis. Cetuximab is a monoclonal antibody - Chemotherapy, radiotherapy and combined modality for Hodgkin's disease, with emphasis on second cancer risk
Cochrane Systematic Reviews, 19-Oct-2005
Second malignancies (SM) are a major late effect of treatment for Hodgkin's disease (HD). Reliable comparisons of SM risk between alternative treatment strategies are lacking. - Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis
Cochrane Systematic Reviews, 21-Dec-2015
Chest physiotherapy is widely used in people with cystic fibrosis in order to clear mucus from the airways. This is an updated version of previously published reviews. - Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old
Cochrane Systematic Reviews, 1-Feb-2016
This Cochrane review was first published in 2005 and updated in 2007, 2012 and now 2015. Acute bronchiolitis is the leading cause of medical emergencies during winter in children younger than two years of age. Chest physiotherapy is sometimes used to assi - Chest physiotherapy for pneumonia in adults
Cochrane Systematic Reviews, 28-Feb-2013
Despite conflicting evidence, chest physiotherapy has been widely used as an adjunctive treatment for adults with pneumonia. - Chest physiotherapy for pneumonia in children
Cochrane Systematic Reviews, 2-Jan-2019
Pneumonia is a lung infection that causes more deaths in children aged under five years than any other single cause. Chest physiotherapy is widely used as adjuvant treatment for pneumonia. Physiotherapy is thought to help remove inflammatory exudates, tra - Chest physiotherapy for preventing morbidity in babies being extubated from mechanical ventilation
Cochrane Systematic Reviews, 22-Apr-2002
Chest physiotherapy has been used to clear secretions and help lung ventilation in newborns who have needed mechanical ventilation for respiratory problems. However, there are concerns about the safety of some forms of chest physiotherapy. - Chest physiotherapy for reducing respiratory morbidity in infants requiring ventilatory support
Cochrane Systematic Reviews, 13-May-2008
Chest physiotherapy (CPT) has been used in many neonatal nurseries around the world to improve airway clearance and treat lung collapse; however, the evidence to support its use has been conflicting. Despite the large number of studies there is very littl
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