- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Dependence on car use has a number of broad health implications, including contributing to physical inactivity, road traffic injury, air pollution and social severance, as well as entrenching lifestyles that require environmentally unsustainable energy us - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Fluid excess may place people undergoing surgery at risk for various complications. Hypertonic salt solution (HS) maintains intravascular volume with less intravenous fluid than isotonic salt (IS) solutions, but may increase serum sodium. This review was - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Postpartum depression is a major health issue for many women from diverse cultures. While pharmacological interventions are an effective treatment for depression, mothers are often reluctant to take antidepressant medication due to concerns about breast m - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The National Institute for Health and Clinical Excellence clinical practice guideline on the treatment of depressive disorder recommended that selective serotonin reuptake inhibitors should be the first-line option when drug therapy is indicated for a dep - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
This is an updated version of the original Cochrane review published in Issue 4, 2008. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Ovarian cancer is the sixth most common cancer and seventh commonest cause of death in women worldwide. Traditionally, many people who have been treated for cancer undergo long-term follow-up in secondary care. However, it has been suggested that the use - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Pre-cancerous lesions of cervix (cervical intraepithelial neoplasia (CIN)) are usually treated with excisional or ablative procedures. In the UK, the National Health Service (NHS) cervical screening guidelines suggest that over 80% of treatments should be - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Historically, whole brain radiation therapy (WBRT) has been the main treatment for brain metastases. Stereotactic radiosurgery (SRS) delivers high-dose focused radiation and is being increasingly utilized to treat brain metastases. The benefit of adding S - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
One of the most challenging milestones for preterm infants is the acquisition of safe and efficient feeding skills. The majority of healthy full term infants are born with skills to coordinate their suck, swallow and respiration. However, this is not the - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Reduced cardiorespiratory fitness (cardiorespiratory deconditioning) is a common consequence of traumatic brain injury (TBI). Fitness training may be implemented to address this impairment. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Tumour hypoxia increases tumour invasiveness and has a negative impact on response to therapy. Hypoxic tumours are also associated with severely anaemic individuals. It has therefore been hypothesised that correcting anaemia, by increasing haemoglobin lev - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Anaphylaxis is an acute systemic allergic reaction, which can be life-threatening. H1-antihistamines are commonly used as an adjuvant therapy in the treatment of anaphylaxis. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Supplementary oxygen is routinely administered to low-risk pregnant women during an elective caesarean section under regional anaesthesia; however, maternal and foetal outcomes have not been well established. This is an update of a review first published - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in combination with a (point) mutation in the second SMN1 allele. This results in degeneration of anter - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a rare neurodegenerative disease. Approximately 5% to 7% of ALS/MND patients report a family history of a similarly affected relative. Superoxide dismutase-1 gene mutations - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
This is an update of a Cochrane review first published in The Cochrane Library in Issue 4, 2006. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Pediatric Graves' disease (GD) is an autoimmune disease in which excessive amounts of thyroid hormones circulate in the blood. Treatments for pediatric GD include antithyroid drugs (ATD), thyroidectomy and radioiodine. Up to date, the optimal therapy rema - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The aim of diabetes management is to normalise blood glucose levels, since improved blood glucose control is associated with reduction in development, and progression, of complications. Nutritional factors affect blood glucose levels, however there is cur - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Diabetes mellitus type 1 is a chronic disease with short and long term complications. Its goals of therapy are to eliminate the symptoms of hyperglycaemia, reduce the long term microvascular and macrovascular complications and allow the patients to achiev - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Alkylating agents, such as cyclophosphamide and ifosfamide, play a major role in the improved survival of children and young adults with bone and soft tissue sarcoma. However, there is still controversy as to their comparative anti-tumour efficacy and pos
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