- Blood pressure lowering efficacy of diuretics as second-line therapy for primary hypertension
Cochrane Systematic Reviews, 12-Aug-2009
Diuretics are widely prescribed for hypertension not only as a first-line drug but also as a second-line drug. Therefore, it is essential to determine the effects of diuretics on blood pressure (BP), heart rate and withdrawals due to adverse effects (WDAE - Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension
Cochrane Systematic Reviews, 26-Aug-2015
Drugs with combined alpha and beta blocking activity are commonly prescribed to treat hypertension. However, the blood pressure (BP) lowering efficacy of this class of beta blockers has not been systematically reviewed and quantified. - Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension
Cochrane Systematic Reviews, 28-Feb-2014
Beta-blockers are one of the classes of drugs frequently used to treat hypertension. Quantifying the blood pressure (BP) lowering effects of nonselective beta-blockers provides important information that aids clinical decision making. - Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension
Cochrane Systematic Reviews, 27-Nov-2014
Partial agonists are a subclass of beta blockers used to treat hypertension in many countries. Partial agonist act by stimulating beta receptors when they are quiescent and blocking beta receptors when they are active. The blood pressure (BP) lowering eff - Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension
Cochrane Systematic Reviews, 18-Oct-2012
Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Ther - Blood pressure lowering efficacy of renin inhibitors for primary hypertension
Cochrane Systematic Reviews, 20-Apr-2017
Hypertension is a chronic condition associated with an increased risk of mortality and morbidity. Renin is the enzyme responsible for converting angiotensinogen to angiotensin I, which is then converted to angiotensin II. Renin inhibitors are a new class - Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia
Cochrane Systematic Reviews, 9-Aug-2009
This is an update of a previous review (McGuinness 2006). - Blood pressure targets for hypertension in older adults
Cochrane Systematic Reviews, 4-Aug-2017
Eight out of 10 major antihypertensive trials in older adults attempted to achieve a target systolic blood pressure (BP) less than 160 mmHg. Collectively these trials demonstrated benefit for treatment, as compared to no treatment, for an older adult with - Blood pressure targets for hypertension in people with diabetes mellitus
Cochrane Systematic Reviews, 31-Oct-2013
When treating elevated blood pressure (BP), doctors often want to know what blood pressure target they should try to achieve. The standard blood pressure target in clinical practice for some time has been less than 140 - 160/90 - 100 mmHg for the general - Blood pressure-lowering efficacy of loop diuretics for primary hypertension
Cochrane Systematic Reviews, 14-May-2015
Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity. Loop diuretics are indicated and used to treat hypertension, but a systematic review of their blood pressure-lowering efficacy o - Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
Cochrane Systematic Reviews, 29-May-2014
Hypertension is a modifiable cardiovascular risk factor. Although it is established that low-dose thiazides reduce mortality as well as cardiovascular morbidity, the dose-related effect of thiazides in decreasing blood pressure has not been subject to a r - Blood pressure-lowering efficacy of reserpine for primary hypertension
Cochrane Systematic Reviews, 16-Dec-2016
Many antihypertensive agents exist today for the treatment of primary hypertension (systolic blood pressure = 140 mmHg or diastolic blood pressure = 90 mmHg, or both). Randomised controlled trials (RCTs) have been carried out to investigate the evidence f - Blood pressure-lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack
Cochrane Systematic Reviews, 2-Aug-2018
Stroke is an important cause of death and disability worldwide. Since high blood pressure is an important risk factor for stroke and stroke recurrence, drugs that lower blood pressure might play an important role in secondary stroke prevention. - Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease
Cochrane Systematic Reviews, 19-Jan-2017
Sickle cell disease is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. Sickle cell disease can cause severe pain, significant end-organ damage, pulmonary complications, - Blood transfusion for treating malarial anaemia
Cochrane Systematic Reviews, 3-Aug-2010
Blood transfusion is used in patients with severe malarial anaemia, but risks adverse reactions, transmission of disease, and is complicated to organize in developing countries. - Blood transfusions for anaemia in patients with advanced cancer
Cochrane Systematic Reviews, 9-Feb-2016
Anaemia occurs in 68% to 77% of patients with advanced cancer, however, only a minority of patients who are admitted to a hospice receive a blood transfusion. It is unclear what the benefit of blood transfusion is in advanced cancer, who is most likely to - Blue-light filtering intraocular lenses (IOLs) for protecting macular health
Cochrane Systematic Reviews, 16-May-2018
An intraocular lens (IOL) is a synthetic lens that is surgically implanted within the eye following removal of the crystalline lens, during cataract surgery. While all modern IOLs attenuate the transmission of ultra-violet (UV) light, some IOLs, called bl - Blunt versus sharp suture needles for preventing percutaneous exposure incidents in surgical staff
Cochrane Systematic Reviews, 23-Mar-2016
Surgeons and their assistants are especially at risk of exposure to blood due to glove perforations and needle stick injuries during operations. The use of blunt needles can reduce this risk because they don't penetrate skin easily but still perform suffi - Body positioning for spontaneously breathing preterm infants with apnoea
Cochrane Systematic Reviews, 6-Feb-2017
It has been proposed that body positioning in preterm infants, as compared with other, more invasive measures, may be an effective method of reducing clinically significant apnoea. - Bone grafts and bone substitutes for treating distal radial fractures in adults
Cochrane Systematic Reviews, 23-Mar-2009
Surgical treatment of fractures of the distal radius can involve the implantation of bone scaffolding materials (bone grafts and substitutes) into bony defects that frequently arise after fracture reduction.
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