- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Risperidone is the first new generation antipsychotic drug made available in a long-acting injection formulation. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Schizophrenia is usually considered an illness of young adulthood. However, onset after the age of 40 years is reported in 23% of patients hospitalised with schizophrenia. At least 0.1% of the world's elderly population have a diagnosis of late-onset schi - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Epilepsy affects approximately 1% of the population, with up to 30% of patients continuing to have seizures, despite antiepileptic drug treatment. Clobazam is a 1,5-benzodiazepine and is commonly used as an add-on treatment for drug-resistant epilepsy. Th - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Spasticity commonly affects patients with motor neuron disease. It is likely to contribute to worsening muscle dysfunction, increased difficulty with activities of daily living and deteriorating quality of life. This is an update of a review first publish - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
An ignition interlock device is part of a multi-dimensional programme aimed at reducing recidivism in convicted drink drivers. To operate a vehicle equipped with an ignition interlock device, the driver must first provide a breath specimen. If the breath - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Hypotonic saline (such as 0.18-0.3% NaCl with dextrose) is commonly used as maintenance fluid in the management of acute infections. In recent years there have been numerous reports of hypotonic saline solutions being associated with adverse outcomes. To - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Fibrin sealants (also referred to as biological glue or fibrin tissue adhesives) have gained increasing popularity as interventions to improve peri-operative (intra- and post-operative) haemostasis and diminish the need for allogeneic red cell transfusion - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Concerns regarding the safety of transfused blood have generated considerable enthusiasm for the use of technologies intended to reduce the use of allogeneic blood (blood from an unrelated donor). Platelet-rich plasmapheresis (PRP) offers an alternative a - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Injury is responsible for an increasing global burden of death and disability. As a result, new models of trauma care have been developed. Many of these, though initially developed in high-income countries (HICs), are now being adopted in low and middle-i - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Post-thrombotic syndrome (PTS) is a long-term complication of deep vein thrombosis (DVT) that is characterised by chronic pain, swelling, and skin changes in the affected limb. One of every three people with DVT will develop post-thrombotic complications - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The prevention of relapse is a major issue in the management of Crohn's disease. Corticosteroids, the mainstay of treatment of acute exacerbations, are not effective for maintenance of remission and its chronic use is limited by numerous adverse events. R - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
It is becoming commonplace for patients to be discharged earlier from acute hospital settings to their own homes and be required to manage various aspects of their own care. This has increased the need for detailed information to be given to patients and/ - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Invasive fungal infection is an important cause of mortality and morbidity in very preterm and very low birth weight infants. Early diagnosis is difficult and treatment is often delayed. Systemically absorbed antifungal agents (usually azoles) are increas - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
This is an update of a Cochrane review first published in The Cochrane Library in Issue 4, 2006 and previously updated in 2009. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Heavy menstrual bleeding significantly impairs the quality of life of many otherwise healthy women. Perception of heavy menstrual bleeding is subjective and management usually depends upon what symptoms are acceptable to the individual. Surgical options i - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Fibroids are the most common benign tumours of the female genital tract and are associated with numerous clinical problems including a possible negative impact on fertility. In women requesting preservation of fertility, fibroids can be surgically removed - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Shortening the duration of radiation therapy would benefit women with early breast cancer treated with breast conserving surgery. It may also improve access to radiation therapy by improving efficiency in radiation oncology departments globally. This can - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Road crashes are a prime cause of death and disability and red-light running is a common cause of crashes at signalised intersections. Red-light cameras are increasingly used to promote compliance with traffic signals. Manual enforcement methods are resou - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Supportive devices such as slings, wheelchair attachments and orthoses have been used to treat subluxation of the shoulder after stroke. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
For people with physical, sensory and cognitive limitations due to stroke, the routine practice of oral health care (OHC) may become a challenge. Evidence-based supported oral care intervention is essential for this patient group.
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