- Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease
Cochrane Systematic Reviews, 2-Jan-2018
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is terminal, progressive neurological condition for which there are no curative treatments. Among people with ALS/MND, fatigue is a common and debilitating symptom, which is ch - Treatment of hypertension in peripheral arterial disease
Cochrane Systematic Reviews, 4-Dec-2013
Peripheral arterial disease (PAD) causes considerable morbidity and mortality. Hypertension is a risk factor for PAD. Treatment for hypertension must be compatible with the symptoms of PAD. Controversy regarding the effects of beta-adrenoreceptor blockade - Treatment of infantile spasms
Cochrane Systematic Reviews, 23-May-2013
Infantile spasms (West's Syndrome) is a syndrome that includes a peculiar type of epileptic seizure—the spasms—and an electroencephalographic (EEG) abnormality often called hypsarrhythmia. Psychomotor retardation is frequently found at follow-up. Approxim - Treatment of Kaposi sarcoma in children with HIV-1 infection
Cochrane Systematic Reviews, 26-Jan-2014
Kaposi sarcoma (KS) remains the second most frequently diagnosed HIV-related malignancy (HRM) worldwide and most common HRM in sub-Saharan Africa where HIV is most prevalent and human herpesvirus 8 (HHV-8), the precipitating agent for the development of K - Treatment of latent tuberculosis infection in HIV infected persons
Cochrane Systematic Reviews, 20-Jan-2010
Individuals with human immunodeficiency virus (HIV) infection are at an increased risk of developing active tuberculosis (TB). It is known that treatment of latent TB infection (LTBI), also referred to as TB preventive therapy or chemoprophylaxis, helps t - Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis
Cochrane Systematic Reviews, 23-Mar-2020
A glioblastoma is a fatal type of brain tumour for which the standard of care is maximum surgical resection followed by chemoradiotherapy, when possible. Age is an important consideration in this disease, as older age is associated with shorter survival a - Treatment of obstructive sleep apnoea for chronic cough in children
Cochrane Systematic Reviews, 7-Mar-2011
Childhood obstructive sleep apnoea (OSA) is a disorder that is characterised by repeated episodes of partial or complete upper airway obstruction (UAO) during sleep that result in disruption of normal ventilation and sleep patterns. Chronic cough in child - Treatment of periodontitis for glycaemic control in people with diabetes mellitus
Cochrane Systematic Reviews, 14-Apr-2022
Glycaemic control is a key component in diabetes mellitus (diabetes) management. Periodontitis is the inflammation and destruction of the underlying supporting tissues of the teeth. Some studies have suggested a bidirectional relationship between glycaemi - Treatment of seizures in multiple sclerosis
Cochrane Systematic Reviews, 8-Jul-2009
Epileptic seizures occur in only a minority of patients with multiple sclerosis (MS), but can have serious consequences. The available literature suggests an association of seizures in MS with cortical and subcortical demyelinating lesions, which suggest - Treatment of severe or progressive Kaposi's sarcoma in HIV-infected adults
Cochrane Systematic Reviews, 29-Aug-2014
Kaposi's sarcoma remains the most common cancer in Sub-Saharan Africa and the second most common cancer in HIV-infected patients worldwide. Since the introduction of highly active antiretroviral therapy (HAART), there has been a decline in its incidence. - Treatment of vaginal bleeding irregularities induced by progestin only contraceptives
Cochrane Systematic Reviews, 16-Oct-2013
Despite their high effectiveness, progestin-only contraceptives are considered less than ideal by the many women who experience irregular vaginal bleeding when using them. Current treatments to control these bleeding problems are not sufficiently effectiv - Treatment of valvular heart disease during pregnancy for improving maternal and neonatal outcome
Cochrane Systematic Reviews, 3-Apr-2011
Valvular heart disease constitutes the majority of all causes of heart disease in pregnancy. In the presence of valvular heart disease, the necessary haemodynamic changes of pregnancy might cause heart failure, leading to severe maternal and fetal morbidi - Treatment options for progression or recurrence of glioblastoma: a network meta‐analysis
Cochrane Systematic Reviews, 5-Jan-2021
Glioblastoma (GBM) is a highly malignant brain tumour that almost inevitably progresses or recurs after first line standard of care. There is no consensus regarding the best treatment/s to offer people upon disease progression or recurrence. For the purpo - Treatment regimens for administration of anti‐vascular endothelial growth factor agents for neovascular age‐related macular degeneration
Cochrane Systematic Reviews, 5-May-2020
Age-related macular degeneration (AMD) is one of the leading causes of permanent blindness worldwide. The current mainstay of treatment for neovascular AMD (nAMD) is intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents: afl - Treatment with disease-modifying drugs for people with a first clinical attack suggestive of multiple sclerosis
Cochrane Systematic Reviews, 25-Apr-2017
The treatment of multiple sclerosis has changed over the last 20 years. The advent of disease-modifying drugs in the mid-1990s heralded a period of rapid progress in the understanding and management of multiple sclerosis. With the support of magnetic reso - Treatments for adults with prominent lower front teeth
Cochrane Systematic Reviews, 23-May-2018
Prominent lower front teeth may be associated with a large or prognathic lower jaw (mandible) or a small or retrusive upper jaw (maxilla). Edward Angle, who may be considered the father of modern orthodontics, classified the malocclusion in this situation - Treatments for breast abscesses in breastfeeding women
Cochrane Systematic Reviews, 12-Aug-2015
The benefits of breastfeeding are well known, and the World Health Organization recommends exclusive breastfeeding for the first six months of life and continuing breastfeeding to age two. However, many women stop breastfeeding due to lactational breast a - Treatments for breast engorgement during lactation
Cochrane Systematic Reviews, 28-Jul-2010
National surveys have shown that painful breasts are the second most common reason for giving up breastfeeding in the first two weeks after birth in the UK. One factor contributing to such pain can be breast engorgement. Views differ as to how engorgement - Treatments for breast engorgement during lactation
Cochrane Systematic Reviews, 18-Sep-2020
Engorgement is the overfilling of breasts with milk, often occurring in the early days postpartum. It results in swollen, hard, painful breasts and may lead to premature cessation of breastfeeding, decreased milk production, cracked nipples and mastitis. - Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews
Cochrane Systematic Reviews, 13-Jan-2017
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic progressive or relapsing and remitting disease that usually causes weakness and sensory loss. The symptoms are due to autoimmune inflammation of peripheral nerves. CIPD affects
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