- Topical agents and dressings for fungating wounds
Cochrane Systematic Reviews, 15-May-2014
Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer. A small proportion of patients may achieve healing following surgical excision, but treatment is usually palliative. Fungating wound man - Topical agents or dressings for pain in venous leg ulcers
Cochrane Systematic Reviews, 14-Nov-2012
Venous leg ulcers affect up to 1% of people at some time in their lives and are often painful. The main treatments are compression bandages and dressings. Topical treatments to reduce pain during and between dressing changes are sometimes used. - Topical anaesthesia for needle-related pain in newborn infants
Cochrane Systematic Reviews, 31-Jan-2017
Hospitalised newborn neonates frequently undergo painful invasive procedures that involve penetration of the skin and other tissues by a needle. One intervention that can be used prior to a needle insertion procedure is application of a topical local anae - Topical anaesthesia plus intracameral lidocaine versus topical anaesthesia alone for phacoemulsification cataract surgery in adults
Cochrane Systematic Reviews, 28-Jul-2020
Phacoemulsification cataract surgery is usually performed in adults under local anaesthesia. Topical anaesthesia, which involves instilling anaesthetic drops to the ocular surface prior to and during surgery, has found large acceptance internationally. It - Topical anaesthetic or vasoconstrictor preparations for flexible fibre-optic nasal pharyngoscopy and laryngoscopy
Cochrane Systematic Reviews, 15-Feb-2011
Nasal pharyngolaryngoscopy (NPL) is performed as an outpatient and inpatient procedure on a daily basis, for a variety of indications. It frequently causes some degree of discomfort to the patient. Various different topical agents, which are intended to r - Topical anaesthetics for pain control during repair of dermal laceration
Cochrane Systematic Reviews, 22-Feb-2017
Topical local anaesthetics provide effective analgesia for patients undergoing numerous superficial procedures, including repair of dermal lacerations. The need for cocaine in topical anaesthetic formulations has been questioned because of concern about a - Topical analgesia for acute otitis media
Cochrane Systematic Reviews, 21-Jun-2011
Acute otitis media (AOM) is a spontaneously remitting disease of which pain is the most distressing symptom. Antibiotics are now known to have less benefit than previously assumed. Topical pain relief may be a satisfactory intervention for AOM sufferers a - Topical analgesics for acute and chronic pain in adults ‐ an overview of Cochrane Reviews
Cochrane Systematic Reviews, 12-May-2017
Topical analgesic drugs are used for a variety of painful conditions. Some are acute, typically strains or sprains, tendinopathy, or muscle aches. Others are chronic, typically osteoarthritis of hand or knee, or neuropathic pain. - Topical and device‐based treatments for fungal infections of the toenails
Cochrane Systematic Reviews, 16-Jan-2020
Onychomycosis refers to fungal infections of the nail apparatus that may cause pain, discomfort, and disfigurement. This is an update of a Cochrane Review published in 2007; a substantial amount of new research warrants a review exclusively on toenails. - Topical and systemic antifungal therapy for chronic rhinosinusitis
Cochrane Systematic Reviews, 10-Sep-2018
This review adds to a series of reviews looking at primary medical management options for patients with chronic rhinosinusitis. - Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis
Cochrane Systematic Reviews, 5-Sep-2018
Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and sinuses. Since fungi were postulated as a potential cause of CRS in the late 1990s, there has been increasing controversy about the use of both topical and systemic antifungal agents - Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation
Cochrane Systematic Reviews, 22-Jan-2021
Patients treated with mechanical ventilation in intensive care units (ICUs) have a high risk of developing respiratory tract infections (RTIs). Ventilator-associated pneumonia (VAP) has been estimated to affect 5% to 40% of patients treated with mechanica - Topical antibiotics for chronic suppurative otitis media
Cochrane Systematic Reviews, 2-Jan-2020
Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and often polymicrobial infection (involving more than one micro-organism) of the middle ear and mastoid cavity, characterised by ear d - Topical antibiotics for preventing surgical site infection in wounds healing by primary intention
Cochrane Systematic Reviews, 7-Nov-2016
Surgical site infections (SSI) can delay wound healing, impair cosmetic outcome and increase healthcare costs. Topical antibiotics are sometimes used to reduce microbial contaminant exposure following surgical procedures, with the aim of reducing SSIs. - Topical antibiotics with steroids for chronic suppurative otitis media
Cochrane Systematic Reviews, 27-Aug-2020
Chronic suppurative otitis media (CSOM) is a chronic inflammation and often polymicrobial infection of the middle ear and mastoid cavity, characterised by ear discharge (otorrhoea) through a perforated tympanic membrane. The predominant symptoms of CSOM a - Topical antibiotics without steroids for chronically discharging ears with underlying eardrum perforations
Cochrane Systematic Reviews, 10-Nov-2008
Chronic suppurative otitis media (CSOM) causes ear discharge and impairs hearing. - Topical antifungal treatments for tinea cruris and tinea corporis
Cochrane Systematic Reviews, 4-Aug-2014
Tinea infections are fungal infections of the skin caused by dermatophytes. It is estimated that 10% to 20% of the world population is affected by fungal skin infections. Sites of infection vary according to geographical location, the organism involved, a - Topical antifungals for seborrhoeic dermatitis
Cochrane Systematic Reviews, 2-May-2015
Seborrhoeic dermatitis is a chronic inflammatory skin condition that is distributed worldwide. It commonly affects the scalp, face and flexures of the body. Treatment options include antifungal drugs, steroids, calcineurin inhibitors, keratolytic agents a - Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis
Cochrane Systematic Reviews, 29-May-2015
Seasonal/perennial allergic conjunctivitis is the most common allergic conjunctivitis, usually with acute manifestations when a person is exposed to allergens and with typical signs and symptoms including itching, redness, and tearing. The clinical signs - Topical anti‐inflammatory agents for seborrhoeic dermatitis of the face or scalp
Cochrane Systematic Reviews, 19-May-2014
Seborrhoeic dermatitis is a chronic inflammatory skin disorder affecting primarily the skin of the scalp, face, chest, and intertriginous areas, causing scaling and redness of the skin. Current treatment options include antifungal, anti-inflammatory, and
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