- Timing of dornase alfa inhalation for cystic fibrosis
Cochrane Systematic Reviews, 9-Mar-2021
Inhalation of the enzyme dornase alfa reduces sputum viscosity and improves clinical outcomes of people with cystic fibrosis. This is an update of a previously published Cochrane Review. - Timing of hypertonic saline inhalation for cystic fibrosis
Cochrane Systematic Reviews, 28-Feb-2020
Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical outcomes of people with cystic fibrosis. This is an update of a previously published Cochrane Review. - Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery
Cochrane Systematic Reviews, 28-Nov-2014
Given the continued rise in cesarean birth rate and the increased risk of surgical site infections after cesarean birth compared with vaginal birth, effective interventions must be established for prevention of surgical site infections. Prophylactic intra - Timing of kidney replacement therapy initiation for acute kidney injury
Cochrane Systematic Reviews, 23-Nov-2022
Acute kidney injury (AKI) is a common condition among patients in intensive care units (ICUs) and is associated with high numbers of deaths. Kidney replacement therapy (KRT) is a blood purification technique used to treat the most severe forms of AKI. The - Timing of pancreatic enzyme replacement therapy (PERT) in cystic fibrosis
Cochrane Systematic Reviews, 2-Aug-2021
Cystic fibrosis (CF) is an autosomal recessive, life-limiting, multisystem disease affecting over 70,000 individuals worldwide. Between 80% and 90% of people with CF suffer with pancreatic exocrine insufficiency, which if left untreated, leads to a poor n - Timing of prophylactic uterotonics for the third stage of labour after vaginal birth
Cochrane Systematic Reviews, 4-Aug-2010
Administration of the uterotonic drugs is one of the main components of the active management of the third stage of labour. The timing of uterotonics varies considerably across the globe and it may have significant implications on the well-being of the mo - Timing of surgery for aneurysmal subarachnoid haemorrhage
Cochrane Systematic Reviews, 29-Aug-2010
The timing of surgery to secure a ruptured aneurysm after a subarachnoid haemorrhage is an important issue. Early clipping of an aneurysm prevents rebleeding, a major cause of death after a subarachnoid haemorrhage. However, concerns about the possible de - Tinnitus Retraining Therapy (TRT) for tinnitus
Cochrane Systematic Reviews, 17-Mar-2010
Tinnitus is described as the perception of sound or noise in the absence of real acoustic stimulation. Although an outright cure for tinnitus remains elusive, various management strategies have been developed to help to lessen the impact of the symptom. F - Tiotropium for stable chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 20-Apr-2005
Tiotropium is a new anticholinergic therapy for chronic obstructive pulmonary disease (COPD) that differs from ipratropium by its functional relative selectivity for muscarinic receptor subtypes and which allows once-per-day dosing. - Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 22-Sep-2015
Tiotropium and ipratropium bromide are both recognised treatments in the management of people with stable chronic obstructive pulmonary disease (COPD). There are new studies which have compared tiotropium with ipratropium bromide, making an update necessa - Tiotropium versus long‐acting beta‐agonists for stable chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 12-Sep-2012
Tiotropium and long-acting beta2-agonists (LABAs) are both accepted in the routine management for people with stable chronic obstructive pulmonary disease (COPD). There are new studies which have compared tiotropium with LABAs, including some that have ev - Tiotropium versus placebo for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 21-Jul-2014
Tiotropium is an anticholinergic agent which has gained widespread acceptance as a once daily maintenance therapy for symptoms and exacerbations of stable chronic obstructive pulmonary disease (COPD). In the past few years there have been several systemat - TIPS versus paracentesis for cirrhotic patients with refractory ascites
Cochrane Systematic Reviews, 18-Oct-2006
Refractory ascites (ie, ascites that cannot be mobilized despite sodium restriction and diuretic treatment) occurs in 10 per cent of patients with cirrhosis. It is associated with substantial morbidity and mortality with a one-year survival rate of less t - Tirilazad for acute ischaemic stroke
Cochrane Systematic Reviews, 30-Aug-2010
Tirilazad mesylate is neuroprotective in experimental models of ischaemic stroke suggesting it might be of benefit clinically. - Tirilazad for aneurysmal subarachnoid haemorrhage
Cochrane Systematic Reviews, 17-Feb-2010
Delayed cerebral ischaemia is a significant contributor to poor outcome (death or disability) in patients with aneurysmal subarachnoid haemorrhage (SAH). Tirilazad is considered to have neuroprotective properties in animal models of acute cerebral ischaem - Tissue adhesives for closure of surgical incisions
Cochrane Systematic Reviews, 28-Nov-2014
Sutures (stitches), staples and adhesive tapes have been used for many years as methods of wound closure, but tissue adhesives have entered clinical practice more recently. Closure of wounds with sutures enables the closure to be meticulous, but the sutur - Tissue adhesives for traumatic lacerations in children and adults
Cochrane Systematic Reviews, 4-Nov-2008
Tissue adhesives have been used for many years to close simple lacerations as an alternative to standard wound closure (sutures, staples, adhesive strips). Potential advantages over standard wound closure include ease of use, decrease in pain, time to app - Titrated oral misoprostol for augmenting labour to improve maternal and neonatal outcomes
Cochrane Systematic Reviews, 23-Sep-2013
Labour dystocia is associated with a number of adverse maternal and neonatal outcomes. Augmentation of labour is a commonly used intervention in cases of labour dystocia. Misoprostol is an inexpensive and stable prostaglandin E1 analogue that can be admin - TNF-alpha inhibitors for ankylosing spondylitis
Cochrane Systematic Reviews, 26-Mar-2015
TNF (tumor necrosis factor)-alpha inhibitors block a key protein in the inflammatory chain reaction responsible for joint inflammation, pain, and damage in ankylosing spondylitis. - TNF‐α blockers for the treatment of Kawasaki disease in children
Cochrane Systematic Reviews, 16-Aug-2019
Kawasaki disease (KD) is an acute inflammatory vasculitis (inflammation of the blood vessels) that mainly affects children between six months and five years of age. The vasculitis primarily impacts medium-sized blood vessels, especially in the coronary ar
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