- Topical microbicides for prevention of sexually transmitted infections
Cochrane Systematic Reviews, 8-May-2012
Two decades of research on topical microbicides for prevention of sexually transmitted infections (STIs) have had limited success. However, new microbicide randomised controlled trial (RCT) data have recently been published; but these have not yet been th - Topical negative pressure for treating chronic wounds
Cochrane Systematic Reviews, 9-Jun-2015
Chronic wounds mainly affect the elderly and those with multiple health problems. Despite the use of modern dressings, some of these wounds take a long time to heal, fail to heal, or recur, causing significant pain and discomfort to the person and cost to - Topical non-steroidal anti-inflammatory agents for diabetic cystoid macular oedema
Cochrane Systematic Reviews, 12-Feb-2015
Diabetic cystoid macular oedema (CMO) is a condition which involves fluid accumulation in the inner portion of the retina. It often follows changes in retinal blood vessels which enhance the fluid to come out of vessels. Although it may be asymptomatic, s - Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions
Cochrane Systematic Reviews, 18-May-2017
Traumatic corneal abrasions are relatively common and there is a lack of consensus about analgesia in their management. It is therefore important to document the clinical efficacy and safety profile of topical ophthalmic non-steroidal anti-inflammatory dr - Topical NSAIDs for acute musculoskeletal pain in adults
Cochrane Systematic Reviews, 29-May-2019
Use of topical NSAIDs to treat acute musculoskeletal conditions has become widely accepted because they can provide pain relief without associated systemic adverse events. This review is an update of 'Topical NSAIDs for acute pain in adults' originally pu - Topical pimecrolimus for eczema
Cochrane Systematic Reviews, 22-Mar-2009
Pimecrolimus was developed as an alternative to topical corticosteroids for treating eczema (atopic dermatitis) but its efficacy and safety compared with existing treatments remains unclear. - Topical preparations for preventing stretch marks in pregnancy
Cochrane Systematic Reviews, 5-Oct-2012
Striae gravidarum (stretch marks developing during pregnancy) occur in 50% to 90% of women. They appear as red or purple lines or streaks that fade slowly to leave pale lines or marks on the skin. The abdomen, breasts and thighs are commonly affected. The - Topical silver for treating infected wounds
Cochrane Systematic Reviews, 6-Sep-2010
Topical silver treatments and silver dressings are increasingly used for the local treatment of contaminated or infected wounds, however, there is a lack of clarity regarding the evidence for their effectiveness. - Topical steroid for chronic rhinosinusitis without polyps
Cochrane Systematic Reviews, 25-Apr-2016
Topical corticosteroid is used as part of a comprehensive medical treatment for chronic rhinosinusitis (CRS) without polyps. Nevertheless, there is insufficient evidence to show a clear overall benefit. Trials studying the efficacy of topical corticostero - Topical steroids for nasal polyps
Cochrane Systematic Reviews, 25-Apr-2016
Chronic rhinosinusitis with nasal polyps (CRSwNP) represents inflammatory changes throughout the nose and sinuses from a group of disorders which all lead to swelling and overgrowth of the nasal mucosa. Topical corticosteroids have been the most widely us - Topical treatments for blepharokeratoconjunctivitis in children
Cochrane Systematic Reviews, 7-Feb-2017
Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the corne - Topical treatments for cutaneous warts
Cochrane Systematic Reviews, 4-Feb-2014
Viral warts are a common skin condition, which can range in severity from a minor nuisance that resolve spontaneously to a troublesome, chronic condition. Many different topical treatments are available. - Topical treatments for HIV-related oral ulcers
Cochrane Systematic Reviews, 5-Dec-2011
In HIV-infected adults, oral ulcers occur more frequently, last longer and produce more painful symptoms than in immunocompetent people. Oral aphthous ulcers observed during the course of HIV infection may be severe and can result in significant morbidity - Topical treatments for scalp psoriasis
Cochrane Systematic Reviews, 24-Feb-2016
People with chronic plaque psoriasis often have lesions on the scalp. Hair makes the scalp difficult to treat and the adjacent facial skin is particularly sensitive to topical treatments. - Topical umbilical cord care at birth
Cochrane Systematic Reviews, 4-Oct-2016
Umbilical cord infection caused many neonatal deaths before aseptic techniques were used. - Topical Vitamin A, or its derivatives, for treating and preventing napkin dermatitis in infants
Cochrane Systematic Reviews, 22-Mar-2009
Napkin dermatitis (nappy or diaper rash) is a non-specific term used to describe inflammatory eruptions (rashes) in the napkin area. Most infants develop napkin dermatitis at least once during their infancy. Topical vitamin A has been suggested as a treat - Topically applied anaesthetics for treating perineal pain after childbirth
Cochrane Systematic Reviews, 29-Oct-2008
Perineal trauma is a major problem affecting millions of women around the world each year. The degree of perineal pain and discomfort associated with perineal trauma is often underestimated. Pain often interferes with basic daily activities for the woman - Topiramate for essential tremor
Cochrane Systematic Reviews, 14-Apr-2017
Essential tremor (ET) is one of the most common movement disorders. The management is primarily based on pharmacological agents and in clinical practice propranolol and primidone are considered the first-line therapy. However, these treatments can be inef - Topiramate for neuropathic pain and fibromyalgia in adults
Cochrane Systematic Reviews, 4-Jul-2016
Topiramate is an antiepileptic drug with multiple possible mechanisms of action. Antiepileptic drugs are widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and many guidelines recommend them. - Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review
Cochrane Systematic Reviews, 23-May-2019
This is an updated version of the original Cochrane Review published in Issue 12, 2016. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons.
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