- Topical capsaicin (low concentration) for chronic neuropathic pain in adults
Cochrane Systematic Reviews, 29-May-2019
Topical creams with capsaicin are used to treat pain from a wide range of chronic conditions including neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity to noxious stimuli, followed by a period with reduced sensitiv - Topical clonidine for neuropathic pain
Cochrane Systematic Reviews, 2-Sep-2015
Clonidine is a presynaptic alpha-2-adrenergic receptor agonist used for many years to treat hypertension and other conditions, including chronic pain. Adverse events associated with systemic use of the drug have limited its application. Topical use of dru - Topical corticosteroids as adjunctive therapy for bacterial keratitis
Cochrane Systematic Reviews, 16-Oct-2014
Bacterial keratitis is a serious ocular infectious disease that can lead to severe visual disability. Risk factors for bacterial corneal infection include contact lens wear, ocular surface disease, corneal trauma, and previous ocular or eyelid surgery. To - Topical corticosteroids for treating phimosis in boys
Cochrane Systematic Reviews, 29-Aug-2014
Until recently, phimosis has been treated surgically by circumcision or prepuceplasty; however, recent reports of non-invasive treatment using topical corticosteroids applied for four to eight weeks have been favourable. The efficacy and safety of topical - Topical cyclosporine A therapy for dry eye syndrome
Cochrane Systematic Reviews, 13-Sep-2019
Topical cyclosporine A (also known as ciclosporin A) (CsA) is an anti-inflammatory that has been widely used to treat inflammatory ocular surface diseases. Two CsA eyedrops have been approved by US Food and Drug Administration for managing dry eye: Restas - Topical cyclosporine for atopic keratoconjunctivitis
Cochrane Systematic Reviews, 19-Jul-2012
Atopic keratoconjunctivitis (AKC) is a chronic ocular surface non-infectious inflammatory condition that atopic dermatitis patients may suffer at any time point in the course of their dermatologic disease and is independent of its degree of severity. AKC - Topical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis‐related lung disease
Cochrane Systematic Reviews, 17-Jun-2016
Cystic fibrosis is caused by a defective gene encoding a protein called the cystic fibrosis transmembrane conductance regulator (CFTR), and is characterised by chronic lung infection resulting in inflammation and progressive lung damage that results in a - Topical emollient for preventing infection in preterm infants
Cochrane Systematic Reviews, 7-May-2021
Breakdown of the developmentally immature epidermal barrier may permit entry for micro-organisms leading to invasive infection in preterm infants. Topical emollients may improve skin integrity and barrier function and thereby prevent invasive infection, a - Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents
Cochrane Systematic Reviews, 20-Oct-2003
Topical fluoride therapy (TFT) in the form of varnish, gel, mouthrinse or toothpaste has been used extensively as a caries-preventive intervention for over 3 decades. - Topical fluoride as a cause of dental fluorosis in children
Cochrane Systematic Reviews, 20-Jan-2010
For many years, topical use of fluorides has gained greater popularity than systemic use of fluorides. A possible adverse effect associated with the use of topical fluoride is the development of dental fluorosis due to the ingestion of excessive fluoride - Topical glyceryl trinitrate for rotator cuff disease
Cochrane Systematic Reviews, 7-Jul-2009
Rotator cuff disease is a common cause of shoulder pain. Topical glyceryl trinitrate is a possible new treatment. - Topical herbal therapies for treating osteoarthritis
Cochrane Systematic Reviews, 31-May-2013
Before extraction and synthetic chemistry were invented, musculoskeletal complaints were treated with preparations from medicinal plants. They were either administered orally or topically. In contrast to the oral medicinal plant products, topicals act in - Topical interventions for genital lichen sclerosus
Cochrane Systematic Reviews, 7-Dec-2011
Lichen sclerosus is a chronic, inflammatory skin condition that most commonly occurs in adult women, although it may also be seen in men and children. It primarily affects the genital area and around the anus, where it causes persistent itching and sorene - Topical lidocaine for neuropathic pain in adults
Cochrane Systematic Reviews, 29-May-2019
Lidocaine is a local anaesthetic that is sometimes used on the skin to treat neuropathic pain. - Topical lidocaine for the treatment of postherpetic neuralgia
Cochrane Systematic Reviews, 10-Jun-2019
This is an update of the original Cochrane review published in Issue 2, 2007. The cause of postherpetic neuralgia is damage to peripheral neurons, dorsal root ganglia, and the dorsal horn of the spinal cord, secondary to herpes zoster infection (shingles) - Topical medication instillation techniques for glaucoma
Cochrane Systematic Reviews, 20-Feb-2017
Glaucoma is a leading cause of irreversible blindness worldwide and the second most common cause of blindness after cataracts. The primary treatment for glaucoma aims to lower intraocular pressure (IOP) with the use of topical medicines. Topical medicatio - Topical microbicides for preventing sexually transmitted infections
Cochrane Systematic Reviews, 13-Mar-2021
This is a updated version of our Cochrane Review published in Issue 6, 2012. Sexually-transmitted infections (STIs) continue to rise worldwide, imposing an enormous morbidity and mortality burden. Effective prevention strategies, including microbicides, a - Topical mydriatics as adjunctive therapy for traumatic iridocyclitis
Cochrane Systematic Reviews, 25-Aug-2020
Traumatic eye complaints account for 3% of all hospital emergency department visits. The most common traumatic injury to the eye is blunt trauma, which accounts for 30% of these visits. Blunt trauma frequently leads to traumatic iridocyclitis, thus causin - Topical nasal steroids for intermittent and persistent allergic rhinitis in children
Cochrane Systematic Reviews, 24-Jan-2007
Allergic rhinitis is a very common chronic illness affecting 10% to 40% of children worldwide. There has been a significant increase in prevalence among children over the last two decades and this increase has been accompanied by a parallel increase in co - Topical nasal steroids for treating nasal polyposis in people with cystic fibrosis
Cochrane Systematic Reviews, 22-Jun-2015
Nasal polyps frequently occur in people with cystic fibrosis. Sinus infections have been shown to be a factor in the development of serious chest complications in these people. Nasal polyps have been linked to a higher risk of lower respiratory tract infe
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