- Topical treatments for fungal infections of the skin and nails of the foot.
Cochrane Systematic Reviews, 1-Mar-2016
Fungal infections of the feet normally occur in the outermost layer of the skin (epidermis). The skin between the toes is a frequent site of infection which can cause pain and itchiness. Fungal infections of the nail (onychomycosis) can affect the entire - Topical treatments for HIV-related oral ulcers
Cochrane Systematic Reviews, 5-Dec-2011
In HIV-infected adults, oral ulcers occur more frequently, last longer and produce more painful symptoms than in immunocompetent people. Oral aphthous ulcers observed during the course of HIV infection may be severe and can result in significant morbidity - Topical treatments for scalp psoriasis
Cochrane Systematic Reviews, 24-Feb-2016
People with chronic plaque psoriasis often have lesions on the scalp. Hair makes the scalp difficult to treat and the adjacent facial skin is particularly sensitive to topical treatments. - Topical umbilical cord care at birth
Cochrane Systematic Reviews, 4-Oct-2016
Umbilical cord infection caused many neonatal deaths before aseptic techniques were used. - Topical versus systemic antibiotics for chronic suppurative otitis media
Cochrane Systematic Reviews,
Chronic suppurative otitis media (CSOM), sometimes referred to as chronic otitis media (COM), is a chronic inflammation and often polymicrobial infection (involving more than one micro-organism) of the middle ear and mastoid cavity, characterised by ear d - Topical Vitamin A, or its derivatives, for treating and preventing napkin dermatitis in infants
Cochrane Systematic Reviews, 22-Mar-2009
Napkin dermatitis (nappy or diaper rash) is a non-specific term used to describe inflammatory eruptions (rashes) in the napkin area. Most infants develop napkin dermatitis at least once during their infancy. Topical vitamin A has been suggested as a treat - Topically applied anaesthetics for treating perineal pain after childbirth
Cochrane Systematic Reviews, 29-Oct-2008
Perineal trauma is a major problem affecting millions of women around the world each year. The degree of perineal pain and discomfort associated with perineal trauma is often underestimated. Pain often interferes with basic daily activities for the woman - Topiramate add‐on therapy for drug‐resistant focal epilepsy
Cochrane Systematic Reviews, 22-Oct-2019
The majority of people with epilepsy have a good prognosis and their seizures are controlled by a single antiepileptic drug. However, up to 20% of patients from population-based studies, and up to 30% from clinical series (not population-based), develop d - Topiramate for acute affective episodes in bipolar disorder in adults
Cochrane Systematic Reviews, 1-Sep-2016
Bipolar disorder is a common recurrent illness with high levels of chronicity. Previous trials have suggested that the anticonvulsant topiramate may be efficacious in bipolar disorder. This is an update of a previous Cochrane review (last published 2006) - Topiramate for essential tremor
Cochrane Systematic Reviews, 14-Apr-2017
Essential tremor (ET) is one of the most common movement disorders. The management is primarily based on pharmacological agents and in clinical practice propranolol and primidone are considered the first-line therapy. However, these treatments can be inef - Topiramate for juvenile myoclonic epilepsy
Cochrane Systematic Reviews, 24-Jan-2019
Topiramate is a newer broad-spectrum antiepileptic drug (AED). Some studies have shown the benefits of topiramate in the treatment of juvenile myoclonic epilepsy (JME). However, there are no current systematic reviews to determine the efficacy and tolerab - Topiramate for neuropathic pain and fibromyalgia in adults
Cochrane Systematic Reviews, 4-Jul-2016
Topiramate is an antiepileptic drug with multiple possible mechanisms of action. Antiepileptic drugs are widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and many guidelines recommend them. - Topiramate for the prophylaxis of episodic migraine in adults
Cochrane Systematic Reviews, 27-May-2016
Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an update of a Cochrane - Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review
Cochrane Systematic Reviews, 23-May-2019
This is an updated version of the original Cochrane Review published in Issue 12, 2016. This review is one in a series of Cochrane Reviews investigating pair-wise monotherapy comparisons. - Topotecan for ovarian cancer
Cochrane Systematic Reviews,
Chemotherapeutic agents such as topotecan can be used as salvage treatment in epithelial ovarian carcinoma (EOC). The effects of using topotecan as a therapeutic agent have not been previously been systematically reviewed. - Toremifene versus tamoxifen for advanced breast cancer
Cochrane Systematic Reviews,
Toremifene (TOR) and tamoxifen (TAM) can both be used as treatments for advanced breast cancer. - Toric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification
Cochrane Systematic Reviews, 16-Dec-2019
Cataract is the leading cause of blindness in the world, and clinically significant astigmatism may affect up to approximately 20% of people undergoing cataract surgery. Pre-existing astigmatism in people undergoing cataract surgery may be treated, among - Total disc replacement for chronic back pain in the presence of disc degeneration
Cochrane Systematic Reviews, 8-Jan-2013
In the search for better surgical treatment of chronic low-back pain (LBP) in the presence of disc degeneration, total disc replacement has received increasing attention in recent years. A possible advantage of total disc replacement compared with fusion - Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery
Cochrane Systematic Reviews, 4-Apr-2017
Rapid implementation of robotic transabdominal surgery has resulted in the need for re-evaluation of the most suitable form of anaesthesia. The overall objective of anaesthesia is to minimize perioperative risk and discomfort for patients both during and - Total or near-total thyroidectomy versus subtotal thyroidectomy for multinodular non-toxic goitre in adults
Cochrane Systematic Reviews, 4-Aug-2015
Total thyroidectomy (TT) and subtotal thyroidectomy (ST) are worldwide treatment options for multinodular non-toxic goitre in adults. Near TT, defined as a postoperative thyroid remnant less than 1 mL, is supposed to be a similarly effective but safer opt
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