- Antipsychotic combinations for schizophrenia
Cochrane Systematic Reviews, 28-Jun-2017
Many people with schizophrenia do not achieve a satisfactory treatment response with their initial antipsychotic drug treatment. Sometimes a second antipsychotic, in combination with the first, is used in these situations. - Antipsychotic drug treatment for elderly people with late‐onset schizophrenia
Cochrane Systematic Reviews, 15-Feb-2012
Schizophrenia is usually considered an illness of young adulthood. However, onset after the age of 40 years is reported in 23% of patients hospitalised with schizophrenia. At least 0.1% of the world's elderly population have a diagnosis of late-onset schi - Antipsychotic drugs for non-affective psychosis during pregnancy and postpartum
Cochrane Systematic Reviews, 20-Oct-2008
Antipsychotics are commonly prescribed for women suffering psychotic illnesses during pregnancy and the postpartum period. The potential adverse consequences of these different options are multiple and complex, impacting on the foetus, neonate, infant and - Antipsychotic medication for challenging behaviour in people with learning disability
Cochrane Systematic Reviews, 11-Nov-2008
The term 'challenging behaviour', in the absence of psychiatric disorder, encompasses a wide range of behaviours that may be harmful to people or property, may be difficult to manage and may limit access to community facilities. Antipsychotic medications - Antipsychotic medication for childhood‐onset schizophrenia
Cochrane Systematic Reviews, 18-Jul-2007
Childhood-onset schizophrenia is schizophrenia with onset prior to the age of 13 years. Although it is rare, people who suffer from schizophrenia at an early age appear to have a clinically severe form of the illness with poor long-term prognosis. Antipsy - Antipsychotic medication for early episode schizophrenia
Cochrane Systematic Reviews, 16-Feb-2017
Long-term treatment with antipsychotic medications in early episode schizophrenia spectrum disorders is common, but both short and long-term effects on the illness are unclear. There have been numerous suggestions that people with early episodes of schizo - Antipsychotic medication for elderly people with schizophrenia
Cochrane Systematic Reviews, 25-Jan-2006
A large and growing number of older people across the world suffer from schizophrenia. Recommendations for their treatment are largely based on data extrapolated from studies of the use of antipsychotic medications in younger populations. In addition most - Antipsychotic medication versus placebo for people with both schizophrenia and learning disability
Cochrane Systematic Reviews, 17-Dec-2012
Antipsychotic medication is the standard treatment for people with learning disability and schizophrenia. - Antipsychotic medications for cocaine dependence
Cochrane Systematic Reviews, 19-Mar-2016
Cocaine dependence is a public health problem characterised by recidivism and a host of medical and psychosocial complications. Cocaine dependence remains a disorder for which no pharmacological treatment of proven efficacy exists. - Antipsychotic polypharmacy reduction versus polypharmacy continuation for people with schizophrenia
Cochrane Systematic Reviews, 30-Aug-2022
In clinical practice, different antipsychotics can be combined in the treatment of people with schizophrenia (polypharmacy). This strategy can aim at increasing efficacy, but might also increase the adverse effects due to drug–drug interactions. Reducing - Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia
Cochrane Systematic Reviews, 6-Feb-2018
Since the 1950s antipsychotic medication has been extensively used to treat people with chronic mental illnesses such as schizophrenia. These drugs, however, have also been associated with a wide range of adverse effects, including movement disorders such - Antipsychotic switching for people with schizophrenia who have neuroleptic-induced weight or metabolic problems
Cochrane Systematic Reviews, 24-Jan-2013
Weight gain is common for people with schizophrenia and this has serious implications for a patient's health and well being. Switching strategies have been recommended as a management option. - Antipsychotics for acute and chronic pain in adults
Cochrane Systematic Reviews, 29-Aug-2013
This is an updated version of the original Cochrane review published in Issue 4, 2008. The role of antipsychotics as adjuvant analgesics is a subject of longstanding controversy. Neuroleptanalgesia (that is a state of quiescence, altered awareness, and an - Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia
Cochrane Systematic Reviews, 17-Dec-2021
Typical and atypical antipsychotics are widely used to treat agitation and psychosis in dementia. However, whether or not they are beneficial is uncertain. Some trials have yielded negative results and effectiveness may be outweighed by harms. - Antipsychotics for fibromyalgia in adults
Cochrane Systematic Reviews, 2-Jun-2016
This review is one of a series on drugs used to treat fibromyalgia. Fibromyalgia is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue. It affects - Antipsychotics for schizophrenia spectrum disorders with catatonic symptoms
Cochrane Systematic Reviews, 12-Jul-2022
Whilst antipsychotics are the mainstay of treatment for schizophrenia spectrum disorders, there have been numerous attempts to identify biomarkers that can predict treatment response. One potential marker may be psychomotor abnormalities, including catato - Antipsychotics for treatment of delirium in hospitalised non‐ICU patients
Cochrane Systematic Reviews, 18-Jun-2018
Guidelines suggest limited and cautious use of antipsychotics for treatment of delirium where nonpharmacological interventions have failed and symptoms remain distressing or dangerous, or both. It is unclear how well these recommendations are supported by - Antipyretic measures for treating fever in malaria
Cochrane Systematic Reviews, 12-Sep-2012
Fever is common in malaria, and drugs and sponging are widely used for symptomatic relief. Some researchers have suggested that fever reduction may prolong malaria illness. - Antiretroviral interventions for preventing breast milk transmission of HIV
Cochrane Systematic Reviews, 28-Sep-2014
An estimated 260,000 children under the age of 15 years acquired HIV infection in 2012. As much as 42% of mother-to-child transmission is related to breastfeeding. Antiretroviral prophylaxis for mothers or infants has the potential to prevent mother-to-ch - Antiretroviral post‐exposure prophylaxis (PEP) for occupational HIV exposure
Cochrane Systematic Reviews, 24-Jan-2007
Populations such as healthcare workers (HCWs), injection drug users (IDUs), and people engaging in unprotected sex are all at risk of being infected with the human immunodeficiency virus (HIV). Animal models show that after initial exposure, HIV replicate
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