- Screening for prevention of optic nerve damage due to chronic open angle glaucoma
Cochrane Systematic Reviews, 17-Feb-2009
Open angle glaucoma (OAG) is a primary, progressive optic neuropathy; the onset is without symptoms and progression occurs silently until the advanced stages of the disease, when it affects central vision. The blindness caused by OAG is irreversible. It h - Screening for testicular cancer
Cochrane Systematic Reviews, 15-Mar-2011
Testicular cancer commonly affects men aged between 20 and 35 years. Screening for testicular cancer may reduce both morbidity and mortality, yet the effectiveness of any method is unknown. Equally, screening may also promote treatment procedures that are - Screening programmes for developmental dysplasia of the hip in newborn infants
Cochrane Systematic Reviews, 21-Jul-2011
Uncorrected developmental dysplasia of the hip (DDH) is associated with long term morbidity such as gait abnormalities, chronic pain and degenerative arthritis. - Screening programmes for the early detection and prevention of oral cancer
Cochrane Systematic Reviews, 19-Nov-2013
Oral cancer is an important global healthcare problem, its incidence is increasing and late-stage presentation is common. Screening programmes have been introduced for a number of major cancers and have proved effective in their early detection. Given the - Screening with urinary dipsticks for reducing morbidity and mortality
Cochrane Systematic Reviews, 5-Jan-2015
Urinary dipsticks are sometimes used for screening asymptomatic people, and for case-finding among inpatients or outpatients who do not have genitourinary symptoms. Abnormalities identified on screening sometimes lead to additional investigations, which m - Sealing procedures for preterm prelabour rupture of membranes
Cochrane Systematic Reviews, 6-Jul-2016
Preterm prelabour rupture of the membranes (PPROM) complicates approximately 2% of pregnancies and can be either spontaneous or iatrogenic in nature. Complications of PPROM include prematurity, chorioamnionitis, neonatal sepsis, limb position defects, res - Second or third additional chemotherapy drug for non-small cell lung cancer in patients with advanced disease
Cochrane Systematic Reviews, 8-Mar-2012
Randomized trials have demonstrated that adding a drug to a single-agent or to a two-agent regimen increased the tumor response rate in patients with advanced non-small cell lung cancer (NSCLC), although its impact on survival remains controversial. - Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate
Cochrane Systematic Reviews, 9-May-2011
Secondary alveolar bone grafting has been widely used to reconstruct alveolar cleft. However, there is still some controversy. - Secondary prevention of recurrent venous thromboembolism after initial oral anticoagulation therapy in patients with unprovoked venous thromboembolism
Cochrane Systematic Reviews, 15-Dec-2017
Currently, little evidence is available on the length and type of anticoagulation used for extended treatment for prevention of recurrent venous thromboembolism (VTE) in patients with unprovoked VTE who have completed initial oral anticoagulation therapy. - Secondary suturing compared to non-suturing for broken down perineal wounds following childbirth
Cochrane Systematic Reviews, 23-Sep-2013
Each year approximately 350,000 women in the United Kingdom and millions more worldwide, experience perineal suturing following childbirth. The postpartum management of perineal trauma is a core component of routine maternity care. However, for those wome - Second-generation antidepressants for preventing seasonal affective disorder in adults
Cochrane Systematic Reviews, 15-Apr-2019
Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. The predictable sea - Second-generation antidepressants for seasonal affective disorder
Cochrane Systematic Reviews, 7-Nov-2011
Seasonal affective disorder (SAD) is a seasonal pattern of recurrent depressive episodes that is often treated with second-generation antidepressants (SGAs), light therapy or psychotherapy. - Second-generation antipsychotics for anxiety disorders
Cochrane Systematic Reviews, 26-Oct-2011
Anxiety disorders are common and disabling conditions, with a lifetime prevalence of 17% in the general population. Due to high rates of treatment resistance, there is interest in new pharmacological treatment options such as second-generation antipsychot - Second-generation antipsychotics for major depressive disorder and dysthymia
Cochrane Systematic Reviews, 18-Jan-2012
Major depressive disorder (MDD) is a common condition with a lifetime prevalence of 15% to 18%, which leads to considerable suffering and disability. Some antipsychotics have been reported to induce remission in major depression, when added to an antidepr - Second-generation antipsychotics for obsessive compulsive disorder
Cochrane Systematic Reviews, 10-Nov-2010
Obsessive compulsive disorder (OCD) is a psychiatric disorder which has been shown to affect 2 to 3.5% of people during their lifetimes. Inadequate response occurs in 40% to 60% of people that are prescribed first line pharmaceutical treatments (selective - Second-line systemic therapy for metastatic colorectal cancer
Cochrane Systematic Reviews, 9-Dec-2016
The therapeutic management of people with metastatic colorectal cancer (CRC) who did not respond to first-line treatment represents a formidable challenge. - Sedative techniques for endoscopic retrograde cholangiopancreatography
Cochrane Systematic Reviews, 13-May-2012
Endoscopic retrograde cholangiopancreatography (ERCP) is an uncomfortable therapeutic procedure that cannot be performed without adequate sedation or general anaesthesia. A considerable number of ERCPs are performed annually in the UK (at least 48,000) an - Sedatives for opiate withdrawal in newborn infants
Cochrane Systematic Reviews, 7-Sep-2010
Neonatal abstinence syndrome (NAS) due to opiate withdrawal may result in disruption of the mother-infant relationship, sleep-wake abnormalities, feeding difficulties, weight loss and seizures. Treatments used to ameliorate symptoms and reduce morbidity i - Selective computed tomography (CT) versus routine thoracoabdominal CT for high-energy blunt-trauma patients
Cochrane Systematic Reviews, 17-Dec-2013
Trauma is the fifth leading cause of death worldwide, and in people younger than 40 years of age, it is the leading cause of death. During the resuscitation of trauma patients at the emergency department, there are two different commonly used diagnostic s - Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)
Cochrane Systematic Reviews, 8-Aug-2013
Autism spectrum disorders (ASD) are characterised by abnormalities in social interaction and communication skills, as well as stereotypic behaviours and restricted activities and interests. Selective serotonin reuptake inhibitors (SSRIs) are prescribed fo
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