- Statins for primary prevention of venous thromboembolism
Cochrane Systematic Reviews, 18-Dec-2014
Venous thromboembolism (VTE) is common in clinical practice. The efficacy of statins in the primary prevention of VTE remains unproven. This is an update of the review first published in 2011. - Statins for Smith‐Lemli‐Opitz syndrome
Cochrane Systematic Reviews, 14-Nov-2022
Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital malformations syndrome caused by defective cholesterol biosynthesis. Affected individuals show cholesterol deficiency and accumulation of various precursor molecules, mainly 7-dehydrocholesterol a - Statins for the prevention of dementia
Cochrane Systematic Reviews, 4-Jan-2016
This is an update of a Cochrane review first published in 2001 and then updated in 2009. Vascular risk factors including high cholesterol levels increase the risk of dementia due to Alzheimer's disease and of vascular dementia. Some observational studies - Statins for the primary prevention of cardiovascular disease
Cochrane Systematic Reviews, 31-Jan-2013
Reducing high blood cholesterol, a risk factor for cardiovascular disease (CVD) events in people with and without a past history of CVD is an important goal of pharmacotherapy. Statins are the first-choice agents. Previous reviews of the effects of statin - Statins for the treatment of dementia
Cochrane Systematic Reviews, 2-Jul-2014
The use of statin therapy in established Alzheimer's disease (AD) or vascular dementia (VaD) is a relatively unexplored area. In AD, ß-amyloid protein (Aß) is deposited in the form of extracellular plaques and previous studies have determined Aß generatio - Statins for women with polycystic ovary syndrome not actively trying to conceive
Cochrane Systematic Reviews, 7-Sep-2011
Statins, as lipid-lowering agents with pleiotropic actions, are likely not only to improve the dyslipidaemia associated with polycystic ovary syndrome but may also exert other beneficial metabolic and endocrine effects. - Statins versus placebo for people with chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 31-Jul-2019
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable respiratory disease. COPD exacerbations are associated with worse quality of life, increased hospitalisations, and increased mortality. Currently available pharmacologica - Stavudine or zidovudine in three-drug combination therapy for initial treatment of HIV infection in antiretroviral-naïve individuals
Cochrane Systematic Reviews, 15-Mar-2011
The introduction of highly active antiretroviral therapy (ART) as treatment for HIV infection has greatly improved mortality and morbidity for adults and children living with HIV around the world. Two common medications given in first-line antiretroviral - Stavudine, lamivudine and nevirapine combination therapy for treatment of HIV infection and AIDS in adults.
Cochrane Systematic Reviews, 19-Apr-2006
A favourable regimen for people infected with HIV/AIDS is one that provides optimal efficacy, durability of antiretroviral activity, tolerability, and has low adverse effects and drug-drug interactions. The combination of the non-nucleoside reverse transc - Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age
Cochrane Systematic Reviews, 7-Dec-2010
Acute bronchiolitis is a common respiratory infection and a major cause of morbidity in young children. It is treated with bronchodilators (for example, salbutamol), corticosteroids or humidified air (steam inhalation or cool mist). Steam inhalation is pr - Stem cell therapy for chronic ischaemic heart disease and congestive heart failure
Cochrane Systematic Reviews, 24-Dec-2016
A promising approach to the treatment of chronic ischaemic heart disease and congestive heart failure is the use of stem cells. The last decade has seen a plethora of randomised controlled trials developed worldwide, which have generated conflicting resul - Stem cell therapy for dilated cardiomyopathy
Cochrane Systematic Reviews, 21-Jul-2021
Stem cell therapy (SCT) has been proposed as an alternative treatment for dilated cardiomyopathy (DCM), nonetheless its effectiveness remains debatable. - Stem cell therapy for treatment of thromboangiitis obliterans (Buerger's disease)
Cochrane Systematic Reviews, 31-Oct-2018
Thromboangiitis obliterans, also known as Buerger's disease, is a non-atherosclerotic, segmental inflammatory pathology that most commonly affects the small- and medium-sized arteries, veins, and nerves in the upper and lower extremities. The etiology is - Stem cell transplantation for induction of remission in medically refractory Crohn’s disease
Cochrane Systematic Reviews, 13-May-2022
Crohn's disease (CD) is an inflammatory bowel disease that causes inflammation and stricture, of any part of the mucosa and the gut wall. It forms skip lesions, sparing the areas in between the affected parts of the gastrointestinal tract. Crohn's disease - Stem cell transplantation for ischemic stroke
Cochrane Systematic Reviews, 5-May-2019
Stroke is a leading cause of morbidity and mortality worldwide, with very large healthcare and social costs, and a strong demand for alternative therapeutic approaches. Preclinical studies have shown that stem cells transplanted into the brain can lead to - Stem cell transplantation for systemic sclerosis
Cochrane Systematic Reviews, 29-Jul-2022
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by systemic inflammation, fibrosis, vascular injury, reduced quality of life, and limited treatment options. Autologous hematopoietic stem cell transplantation (HSCT) has emerged as a - Stem cell treatment for acute myocardial infarction
Cochrane Systematic Reviews, 30-Sep-2015
Cell transplantation offers a potential therapeutic approach to the repair and regeneration of damaged vascular and cardiac tissue after acute myocardial infarction (AMI). This has resulted in multiple randomised controlled trials (RCTs) across the world. - Stem cell‐based interventions for the prevention and treatment of intraventricular haemorrhage and encephalopathy of prematurity in preterm infants
Cochrane Systematic Reviews, 15-Feb-2023
Germinal matrix-intraventricular haemorrhage (GMH-IVH) and encephalopathy of prematurity (EoP) remain substantial issues in neonatal intensive care units worldwide. Current therapies to prevent or treat these conditions are limited. Stem cell-based therap - Stem cell‐based interventions for the prevention of morbidity and mortality following hypoxic‐ischaemic encephalopathy in newborn infants
Cochrane Systematic Reviews, 19-Aug-2020
Hypoxic-ischaemic encephalopathy (HIE) is a leading cause of mortality and long-term neurological sequelae, affecting thousands of children worldwide. Current therapies to treat HIE are limited to cooling. Stem cell-based therapies offer a potential thera - Stent graft types for endovascular repair of abdominal aortic aneurysms
Cochrane Systematic Reviews, 24-Sep-2015
The UK prevalence of abdominal aortic aneurysm (AAA) is estimated at 4.9% in over 65-year olds. Progressive and unpredictable enlargement can lead to rupture. Endovascular repair of AAAs involves a stent graft system being introduced via the femoral arter
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