- Single dose oral nefopam for acute postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
Nefopam is a centrally-acting but non-opioid analgesic drug of the benzoxazocine chemical class, developed in the early 1970s. It is widely used, mainly in European countries, for the relief of moderate to severe pain as an alternative to opioid analgesic - Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
Oxycodone is a strong opioid agonist used to treat severe pain. It is commonly combined with milder analgesics such as paracetamol. This review updates a previous review that concluded, based on limited data, that all doses of oxycodone exceeding 5 mg, wi - Single dose oral paracetamol (acetaminophen) for postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
This is an updated version of the original Cochrane review published in Issue 1, 2004 - this original review had been split from a previous title on 'Single dose paracetamol (acetaminophen) with and without codeine for postoperative pain'. The last versio - Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
This is an updated version of the Cochrane review published in Issue 4, 1998. Combining drugs from different classes with different modes of action may offer opportunity to optimise efficacy and tolerability, using lower doses of each drug to achieve the - Single dose oral piroxicam for acute postoperative pain
Cochrane Systematic Reviews, 29-May-2019
This is an updated version of the original Cochrane review published in Issue 2, 2000. Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties, and is used mainly for treating rheumatic disorders. Some drugs have been directl - Single dose oral rofecoxib for acute postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
Editor's note: The anti-inflammatory drug rofecoxib (Vioxx) was withdrawn from the market at the end of September 2004 after it was shown that long-term use (greater than 18 months) could increase the risk of heart attack and stroke in a study of secondar - Single dose oral sulindac for acute postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
Sulindac is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and widely available in other countries worldwide. This review sought to evaluate the efficacy and safety of or - Single dose oral tenoxicam for acute postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and is widely available in other countries worldwide. This review sought to evaluate the efficacy and safety o - Single dose oral tiaprofenic acid for acute postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
Tiaprofenic acid is a a non-steroidal anti-inflammatory drug (NSAID). It is widely available around the world, with indications for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, periarticular disorders, and strains and sprains. This review - Single fixed‐dose oral dexketoprofen plus tramadol for acute postoperative pain in adults
Cochrane Systematic Reviews, 29-May-2019
Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and migraine hea - Single herbal medicine for diabetic retinopathy
Cochrane Systematic Reviews, 30-Nov-2018
Diabetic retinopathy is one of the major causes of blindness and the number of cases has risen in recent years. Herbal medicine has been used to treat diabetes and its complications including diabetic retinopathy for thousands of years around the world. H - Single incision versus conventional multi-incision appendicectomy for suspected appendicitis
Cochrane Systematic Reviews, 2-Jun-2011
Appendicectomy is a well established surgical procedure used in the management of acute appendicitis. The operation can be performed with minimally invasive surgery (laparoscopic) or as an open procedure. A recent development in appendicectomy has been t - Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients
Cochrane Systematic Reviews, 20-Dec-2018
The use of etomidate for emergency airway interventions in critically ill patients is very common. In one large registry trial, etomidate was the most commonly used agent for this indication. Etomidate is known to suppress adrenal gland function, but it r - Single layer versus double layer suture anastomosis of the gastrointestinal tract
Cochrane Systematic Reviews, 24-Nov-2011
Gastrointestinal anastomosis (GIA) is an essential step to maintain the continuity of gastrointestinal tract following intestinal resection. GIA is still a source of significant controversy among surgeons due to the use of variety of approaches. Adequate - Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or without bevacizumab for people with advanced non‐small cell lung cancer
Cochrane Systematic Reviews,
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have changed the first-line treatment of people with advanced non-small cell lung cancer (NSCLC). Single-agent pembrolizumab (a PD-1 inhibitor) is currently the standard of care as monother - Single or double-level anterior interbody fusion techniques for cervical degenerative disc disease
Cochrane Systematic Reviews, 13-Feb-2011
The number of surgical techniques for decompression and solid interbody fusion as treatment for cervical spondylosis has increased rapidly, but the rationale for the choice between different techniques remains unclear. - Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis
Cochrane Systematic Reviews,
The choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of - Single versus double volume exchange transfusion in jaundiced newborn infants
Cochrane Systematic Reviews, 23-Sep-2008
Double volume exchange transfusion is commonly used in newborns with severe jaundice in order to prevent kernicterus and other toxicity related to hyperbilirubinemia. Most commonly, exchange transfusions are used in infants with rhesus hemolytic disease. - Single versus multiple visits for endodontic treatment of permanent teeth
Cochrane Systematic Reviews, 30-Nov-2016
Root canal treatment (RoCT), or endodontic treatment, is a common procedure in dentistry. The main indications for RoCT are irreversible pulpitis and necrosis of the dental pulp caused by carious processes, tooth cracks or chips, or dental trauma. Success - Single versus two layer suturing for closing the uterine incision at Caesarean section
Cochrane Systematic Reviews, 3-May-2008
A single layer closure might save operating time, disrupt less tissue, introduce less foreign material into the wound, and thus result in less post operative morbidity.
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