- Pharmacological treatments for preventing epilepsy following traumatic head injury
Cochrane Systematic Reviews, 29-Jul-2015
Head injury is a common event and can cause a spectrum of motor and cognition disabilities. A frequent complication is seizures. Antiepileptic drugs (AED) such as phenytoin are often used in clinical practice with the hopes of preventing post-traumatic ep - Pharmacomechanical thrombectomy for iliofemoral deep vein thrombosis
Cochrane Systematic Reviews, 12-Oct-2016
Deep venous thrombosis (DVT) occurs in approximately one in 1000 adults every year, and has an annual mortality of 14.6%. In particular, iliofemoral DVT can lead to recurrent thrombosis and post-thrombotic syndrome (PTS), a painful condition which can lea - Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders
Cochrane Systematic Reviews, 2-Nov-2008
A large proportion of patients with anxiety disorders fail to respond to first-line medication interventions, despite evidence of the effectiveness of these agents. - Pharmacotherapy for chronic cognitive impairment in traumatic brain injury
Cochrane Systematic Reviews, 30-Nov-2015
Traumatic brain injury (TBI) is a major cause of chronic disability. Worldwide, it is the leading cause of disability in the under 40s, resulting in severe disability in some 150 to 200 million people per annum. In addition to mood and behavioural problem - Pharmacotherapy for hypertension in adults aged 18 to 59 years
Cochrane Systematic Reviews, 16-Aug-2017
Hypertension is an important risk factor for adverse cardiovascular events including stroke, myocardial infarction, heart failure and renal failure. The main goal of treatment is to reduce these events. Systematic reviews have shown proven benefit of anti - Pharmacotherapy for mild hypertension
Cochrane Systematic Reviews, 31-May-2014
People with no previous cardiovascular events or cardiovascular disease represent a primary prevention population. The benefits and harms of treating mild hypertension in primary prevention patients are not known at present. This review examines the exist - Pharmacotherapy for patellofemoral pain syndrome
Cochrane Systematic Reviews, 11-Aug-2008
Patellofemoral pain syndrome (PFPS) is common among adolescents and young adults. It is characterised by pain behind or around the patella and crepitations, provoked by ascending or descending stairs, squatting, prolonged sitting with flexed knees, runnin - Pharmacotherapy for sleep bruxism
Cochrane Systematic Reviews, 13-Oct-2014
Sleep bruxism is an oral activity characterized by involuntary teeth grinding or clenching during sleep. Several forms of treatment have been proposed for this disorder, including behavioural, dental and pharmacological strategies. - Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers
Cochrane Systematic Reviews, 26-Feb-2018
Smoking cessation therapies are not effective for all smokers, and researchers are interested in identifying those subgroups of individuals (e.g. based on genotype) who respond best to specific treatments. - Pharmacotherapy for the prevention of chronic pain after surgery in adults
Cochrane Systematic Reviews, 12-Jun-2017
Chronic pain can often occur after surgery, substantially impairing patients’ health and quality of life. It is caused by complex mechanisms that are not yet well understood. The predictable nature of most surgical procedures has allowed for the conduct o - Pharmacotherapy for trichotillomania
Cochrane Systematic Reviews, 7-Nov-2013
Trichotillomania (TTM) (hair-pulling disorder) is a prevalent and disabling disorder characterised by recurrent hair-pulling. The effect of medication on trichotillomania has not been systematically evaluated. - Pharyngeal instillation of surfactant before the first breath for prevention of morbidity and mortality in preterm infants at risk of respiratory distress syndrome
Cochrane Systematic Reviews, 14-Feb-2011
Intrapartum pharyngeal instillation of surfactant before the first breath may result in surfactant administration to the infant lung, with the potential benefit of avoiding endotracheal intubation and ventilation, ventilator induced lung injury and bronch - Phenytoin for neuropathic pain and fibromyalgia in adults
Cochrane Systematic Reviews, 29-May-2019
Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Phenytoin is an established antiepileptic drug that has been used occasionally to treat intractable trigemin - Phlebotonics for haemorrhoids
Cochrane Systematic Reviews, 9-Jul-2012
Haemorrhoids are variceal dilatations of the anal and perianal venous plexus and often develop secondary to the persistently elevated venous pressure within the haemorrhoidal plexus (Kumar 2005). Phlebotonics are a heterogenous class of drugs consisting o - Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Cochrane Systematic Reviews, 13-Aug-2018
Phosphate binders are used to reduce positive phosphate balance and to lower serum phosphate levels for people with chronic kidney disease (CKD) with the aim to prevent progression of chronic kidney disease-mineral and bone disorder (CKD-MBD). This is an - Phosphodiesterase III inhibitors for heart failure
Cochrane Systematic Reviews, 29-Nov-2012
In the treatment of chronic heart failure, vasodilating agents, ACE inhibitors and beta-blockers have shown an increase of life expectancy. Another strategy is to increase the inotropic state of the myocardium : phosphodiesterase inhibitors (PDIs) act by - Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus
Cochrane Systematic Reviews, 5-Nov-2008
Erectile dysfunction is a common multi-factorial complication of diabetes mellitus. Numerous strategies have been tried to overcome this diabetic complication. In recent years, phosphodiesterase type 5 (PDE-5) inhibitors have been introduced in the manage - Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia
Cochrane Systematic Reviews, 16-Nov-2018
Benign prostatic hyperplasia (BPH) refers to non-malignant enlargement of the prostate gland that may cause bothersome lower urinary tract symptoms (LUTS). Alpha-blockers (ABs) and 5-alpha reductase inhibitors (5-ARIs) are the mainstay of medical treatmen - Photodynamic therapy for neovascular age-related macular degeneration
Cochrane Systematic Reviews, 12-Aug-2009
In neovascular age-related macular degeneration (AMD) new vessels grow under the retina distorting vision and leading to scarring. This is exacerbated if the blood vessels leak. Photodynamic therapy (PDT) has been investigated as a way to treat the neovas - Photodynamic therapy for recurrent respiratory papillomatosis
Cochrane Systematic Reviews, 30-May-2014
Recurrent respiratory papillomatosis (RRP) is a benign condition of the mucosa of the upper aerodigestive tract. It is characterised by recurrent papillomatous lesions and is associated with human papillomavirus (HPV). Frequent recurrence and rapid papill
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