- Chlorpromazine for psychosis induced aggression or agitation
Cochrane Systematic Reviews, 9-Nov-2010
Agitated or violent behaviour constitutes 10% of all emergency psychiatric treatment. Some guidelines do not recommend the use of chlorpromazine for rapid tranquillisation but it is still often used for this purpose. - Chlorpromazine versus clotiapine for schizophrenia
Cochrane Systematic Reviews, 7-Apr-2017
Schizophrenia is a chronic, disabling and severe mental disorder, characterised by disturbance in perception, thought, language, affect and motor behaviour. Chlorpromazine and clotiapine are among antipsychotic drugs used for the treatment of people with - Chlorpromazine versus metiapine for schizophrenia
Cochrane Systematic Reviews, 25-Mar-2017
Chlorpromazine, a widely available and inexpensive antipsychotic drug, is considered the benchmark treatment for schizophrenia worldwide. Metiapine, a dibenzothiazepine derivative, has been reported to have potent antipsychotic characteristics. However, n - Chlorpromazine versus piperacetazine for schizophrenia
Cochrane Systematic Reviews, 29-Oct-2018
Schizophrenia is a severe mental disorder with a prevalence of about 1% among the general population. It is listed among the top 10 causes of disability-adjusted life years (DALYs) worldwide. Antipsychotics are the mainstay treatment. Piperacetazine has b - Chlorpromazine versus placebo for schizophrenia
Cochrane Systematic Reviews, 2-Nov-2015
Chlorpromazine, formulated in the 1950s, remains a benchmark treatment for people with schizophrenia. - Chlorpromazine versus reserpine for schizophrenia
Cochrane Systematic Reviews, 28-Apr-2016
In the 1940s reserpine, refined from a plant extract that had been used for centuries, began to be used as a treatment for people with mental disorders and was one of the very first antipsychotic drugs. Its irreversible pharmacological potency and adverse - Choice of instruments for assisted vaginal delivery
Cochrane Systematic Reviews, 5-Oct-2010
Instrumental or assisted vaginal birth is commonly used to expedite birth for the benefit of either mother or baby or both. It is sometimes associated with significant complications for both mother and baby. The choice of instrument may be influenced by c - Cholecystectomy deferral in patients with endoscopic sphincterotomy
Cochrane Systematic Reviews, 23-Sep-2008
Cholecystectomy is not required in up to 64% of patients who adopt a wait-and-see policy after endoscopic clearance of common bile duct stones. Although reports of retrospective cohort series have shown a higher mortality among patients who defer cholecys - Cholecystectomy for patients with silent gallstones
Cochrane Systematic Reviews, 11-Nov-2008
Cholecystectomy is currently advised only for patients with symptomatic gallstones. However, about 4% of patients with asymptomatic gallstones develop symptoms including cholecystitis, obstructive jaundice, pancreatitis, and gallbladder cancer. - Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage
Cochrane Systematic Reviews, 8-Mar-2013
Cerebral vasospasm and related delayed ischaemic deficits (DIDs) occur in about 17% to 40% of patients with aneurysmal subarachnoid haemorrhage (SAH) and lead to a poor outcome. Cholesterol-reducing agents might improve unfavourable outcomes. - Cholinergic medication for antipsychotic-induced tardive dyskinesia
Cochrane Systematic Reviews, 26-Jan-2018
Tardive dyskinesia (TD) remains a troublesome adverse effect of conventional antipsychotic (neuroleptic) medication. It has been proposed that TD could have a component of central cholinergic deficiency. Cholinergic drugs have been used to treat TD. - Cholinesterase inhibitors for Alzheimer's disease
Cochrane Systematic Reviews, 18-Mar-2016
** This review is awaiting update with a new protocol. The methods used for the review were acceptable when the review was published but do not meet contemporary standards, and the review is also considerably out of date. Therefore, readers should note th - Cholinesterase inhibitors for dementia with Lewy bodies
Cochrane Systematic Reviews, 27-Apr-2008
Dementia with Lewy bodies (DLB) was first described in 1983, and clinical diagnostic criteria were published in the early to mid 1990s. It has been suggested DLB may account for up to 15-25% of cases of dementia among people aged over 65, although autopsy - Cholinesterase inhibitors for mild cognitive impairment
Cochrane Systematic Reviews, 5-Jul-2016
Mild cognitive impairment is hypothesised to represent a pre-clinical stage of dementia but forms a heterogeneous group with variable prognosis. - Cholinesterase inhibitors for Parkinson's disease dementia
Cochrane Systematic Reviews, 5-May-2008
The loss of cholinergic, dopaminergic and noradrenergic innervations seen in Parkinson's Disease Dementia (PDD) suggest a potential role for cholinesterase inhibitors. Concerns have been expressed about a theoretical worsening of Parkinson's disease relat - Cholinesterase inhibitors for rarer dementias associated with neurological conditions
Cochrane Systematic Reviews, 17-Feb-2015
Rarer dementias include Huntington's disease (HD), cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), frontotemporal dementia (FTD), dementia in multiple sclerosis (MS) and progressive supranuclear palsy - Cholinesterase inhibitors for the treatment of delirium in non-ICU settings
Cochrane Systematic Reviews, 27-Jun-2018
Delirium is a common clinical syndrome defined as alterations in attention with an additional disturbance in cognition or perception, which develop over a short period of time and tend to fluctuate during the course of the episode. Delirium is commonly tr - Chorion villus sampling versus amniocentesis for prenatal diagnosis
Cochrane Systematic Reviews, 28-Oct-2008
Amniocentesis test results are usually available only after 18 weeks gestation. Chorion villus sampling (CVS) may be performed transabdominally or transvaginally, usually between 10 and 12 weeks gestation. - Chronic disease management programmes for adults with asthma
Cochrane Systematic Reviews, 26-May-2015
The burden of asthma on patients and healthcare systems is substantial. Interventions have been developed to overcome difficulties in asthma management. These include chronic disease management programmes, which are more than simple patient education, enc - Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia
Cochrane Systematic Reviews, 25-Nov-2016
Elevated levels of total cholesterol and low-density lipoprotein play an important role in the development of atheromas and, therefore, in cardiovascular diseases. Cholesterol biosynthesis follows a circadian rhythm and is principally produced at night (b
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