- Antihistamines used in addition to topical nasal steroids for intermittent and persistent allergic rhinitis in children
Cochrane Systematic Reviews, 14-Jun-2010
Allergic rhinitis is a very common chronic illness affecting 10% to 40% of children worldwide and its prevalence among children has significantly increased over the last two decades. Prevalence and severity are related to age, with children of school age - Antihypertensive agents for preventing diabetic kidney disease
Cochrane Systematic Reviews, 20-Aug-2013
Various blood pressure-lowering agents, and particularly inhibitors of the renin-angiotensin system (RAS), are widely used for people with diabetes to prevent the onset of diabetic kidney disease (DKD) and adverse cardiovascular outcomes. This is an updat - Antihypertensive drug therapy for mild to moderate hypertension during pregnancy
Cochrane Systematic Reviews, 26-Sep-2018
Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent progression to more severe disease, and thereby improve pregnancy outcome. This Cochrane Review is an updated review, first published in 2001 and subsequently up - Anti-hypertensive drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies and clinical trials
Cochrane Systematic Reviews, 20-Sep-2011
Current treatment for Parkinson's disease (PD) is focused on relieving symptoms, at present there is nothing that is widely accepted to halt or slow disease progression. Potential neuroprotective or disease modifying agents have been identified from precl - Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals
Cochrane Systematic Reviews, 3-Mar-2016
High blood pressure is an important public health problem because of associated risks of stroke and cardiovascular events. Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent cardiac events, including myocardial i - Antihypertensive therapy for preventing cardiovascular complications in people with diabetes mellitus
Cochrane Systematic Reviews, 9-Nov-2008
Hypertension and diabetes mellitus are closely associated diseases which are both strongly related to the risk of cardiovascular disease. - Antihypertensive treatment for kidney transplant recipients
Cochrane Systematic Reviews, 29-Nov-2009
In some nontransplant populations, effects of different antihypertensive drug classes vary. Relative effects in kidney transplant recipients are uncertain. - Antihypertensive withdrawal for the prevention of cognitive decline
Cochrane Systematic Reviews, 1-Nov-2016
Clinical trials and observational data have variously shown a protective, harmful or neutral effect of antihypertensives on cognitive function. In theory, withdrawal of antihypertensives could improve cerebral perfusion and reduce or delay cognitive decli - Anti‐IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis
Cochrane Systematic Reviews,
Cystic fibrosis is an autosomal recessive multisystem disorder with an approximate prevalence of 1 in 3500 live births. Allergic bronchopulmonary aspergillosis is a lung disease caused by aspergillus-induced hypersensitivity with a prevalence of 2% to 15% - Anti‐IL‐12/23p40 antibodies for induction of remission in Crohn's disease
Cochrane Systematic Reviews, 24-Nov-2016
Ustekinumab (CNTO 1275) and briakinumab (ABT-874) are monoclonal antibodies that target the standard p40 subunit of the cytokines interleukin-12 and interleukin-23 (IL-12/23p40), which are involved in the pathogenesis of Crohn's disease. - Anti‐IL‐12/23p40 antibodies for maintenance of remission in Crohn's disease
Cochrane Systematic Reviews, 11-Dec-2019
Ustekinumab and briakinumab are monoclonal antibodies that target the standard p40 subunit of cytokines interleukin-12 and interleukin-23 (IL-12/23p40), which are involved in the pathogenesis of Crohn's disease (CD). A significant proportion of people wit - Anti-IL5 therapies for asthma
Cochrane Systematic Reviews, 21-Sep-2017
This review is the first update of a previously published review in The Cochrane Library (Issue 7, 2015). Interleukin-5 (IL-5) is the main cytokine involved in the activation of eosinophils, which cause airway inflammation and are a classic feature of ast - Anti‐IL‐5 therapies for chronic obstructive pulmonary disease
Cochrane Systematic Reviews,
Exacerbations of chronic obstructive pulmonary disease (COPD) are a major cause of hospital admissions, disease-related morbidity and mortality. COPD is a heterogeneous disease with distinct inflammatory phenotypes, including eosinophilia, which may drive - Anti‐inflammatory drugs and analgesics for managing symptoms in people with cystic fibrosis‐related arthritis
Cochrane Systematic Reviews,
Arthritis remains a relatively infrequent complication of cystic fibrosis, but is a cause of significant morbidity when it does occur. Two distinct types of arthritis are described in cystic fibrosis: cystic fibrosis-related arthropathy (CFA) and hypertro - Anti‐inflammatory medications for obstructive sleep apnoea in children
Cochrane Systematic Reviews, 16-Jan-2020
Obstructive sleep apnoea (OSA) is characterised by partial or complete upper airway obstruction during sleep. Approximately 1% to 4% of children are affected by OSA, with adenotonsillar hypertrophy being the most common underlying risk factor. Surgical re - Anti‐inflammatory therapy for preventing stroke and other vascular events after ischaemic stroke or transient ischaemic attack
Cochrane Systematic Reviews,
An increasing body of evidence suggests that inflammation plays a key role in stroke, in particular stroke of atherosclerotic origin. Anti-inflammatory medications are a widely heterogeneous group of drugs that are used to suppress the innate inflammatory - Anti‐inflammatory treatment for carditis in acute rheumatic fever
Cochrane Systematic Reviews, 14-Apr-2016
Rheumatic heart disease remains an important cause of acquired heart disease in developing countries. Although prevention of rheumatic fever and management of recurrences have been well established, optimal management of active rheumatic carditis remains - Anti‐interleukin‐13 and anti‐interleukin‐4 agents versus placebo, anti‐interleukin‐5 or anti‐immunoglobulin‐E agents, for people with asthma
Cochrane Systematic Reviews,
Targeting the immunoglobulin E pathway and the interleukin-5 pathway with specific monoclonal antibodies directed against the cytokines or their receptors is effective in patients with severe asthma. However, there are patients who have suboptimal respons - Anti‐leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children
Cochrane Systematic Reviews, 8-Dec-2014
Anti-leukotrienes (5-lipoxygenase inhibitors and leukotriene receptors antagonists) serve as alternative monotherapy to inhaled corticosteroids (ICS) in the management of recurrent and/or chronic asthma in adults and children. - Antimalarials for treating rheumatoid arthritis
Cochrane Systematic Reviews, 24-May-2010
Antimalarials have been used for the treatment of rheumatoid arthritis (RA) for several decades. Recently several trials have been published with larger sample sizes, and better design than previous studies. These newer trials have evaluated the efficacy
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