- Optimal time for initiating antiretroviral therapy (ART) in HIV-infected, treatment-naive children aged 2 to 5 years old
Cochrane Systematic Reviews, 20-Aug-2013
The use of combination antiretroviral therapy (cART) comprising three antiretroviral medications from at least two classes of drugs is the current standard treatment for HIV infection in adults and children. Current World Health Organization (WHO) guideli - Optimal timing for intravascular administration set replacement
Cochrane Systematic Reviews, 13-Dec-2018
The tubing (administration set) attached to both venous and arterial catheters may contribute to bacteraemia and other infections. The rate of infection may be increased or decreased by routine replacement of administration sets. This review was originall - Optimisation of antiretroviral therapy in HIV-infected children under 3 years of age
Cochrane Systematic Reviews, 1-Mar-2014
In the absence of antiretroviral therapy (ART), over 50% of HIV-infected infants progress to AIDS and death by 2 years of age. However, there are challenges to initiation of ART in early life, including the possibility of drug resistance in the context of - Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant neoplasms, overall and progression-free survival: individual participant data analysis
Cochrane Systematic Reviews, 13-Sep-2017
Efficacy and the risk of severe late effects have to be well-balanced in treatment of Hodgkin lymphoma (HL). Late adverse effects include secondary malignancies which often have a poor prognosis. To synthesise evidence on the risk of secondary malignancie - Optimum duration of regimens for Helicobacter pylori eradication
Cochrane Systematic Reviews, 13-Nov-2013
The optimal duration for Helicobacter pylori (H. pylori) eradication therapy is controversial, with recommendations ranging from 7 to 14 days. Several systematic reviews have attempted to address this issue but have given conflicting results and limited t - Options for self-management education for adults with asthma
Cochrane Systematic Reviews, 29-Mar-2009
Asthma education and self-management are key recommendations of asthma management guidelines because they improve health outcomes. There are several different modalities for the delivery of asthma self-management education. - Oral adsorbents for preventing or delaying the progression of chronic kidney disease
Cochrane Systematic Reviews, 8-Oct-2014
Chronic kidney disease (CKD) is a worldwide public health problem which is at high increased risk of cardiovascular disease (CVD) and renal failure. Deterioration of kidney function causes an increase in circulating toxins, which, in turn promotes the pro - Oral analgesia for relieving post-caesarean pain
Cochrane Systematic Reviews, 1-Apr-2015
Oral analgesia is a convenient and widely used form of pain relief following caesarean section. It includes various medications used at different doses alone or in adjunction to other form of analgesia. - Oral anticoagulants for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks
Cochrane Systematic Reviews, 3-Sep-2008
Non-valvular atrial fibrillation (AF) is associated with an increased risk of stroke mediated by embolism of stasis-precipitated thrombi from the left atrial appendage. - Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no history of stroke or transient ischemic attacks
Cochrane Systematic Reviews, 6-Mar-2011
Non-valvular atrial fibrillation (AF) carries an increased risk of stroke mediated by embolism of stasis-precipitated thrombi originating in the left atrial appendage. Both oral anticoagulants and antiplatelet agents have proven effective for stroke preve - Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes
Cochrane Systematic Reviews, 20-Jan-2017
Gestational diabetes mellitus (GDM) is a major public health issue with rates increasing globally. Gestational diabetes, glucose intolerance first recognised during pregnancy, usually resolves after birth and is associated with short- and long-term compli - Oral antifungal medication for toenail onychomycosis
Cochrane Systematic Reviews, 14-Jul-2017
Fungal infection of the toenails, also called onychomycosis, is a common problem that causes damage to the nail's structure and physical appearance. For those severely affected, it can interfere with normal daily activities. Treatment is taken orally or a - Oral antihistamine-decongestant-analgesic combinations for the common cold
Cochrane Systematic Reviews, 24-Dec-2011
Although combination formulas containing antihistamines, decongestants and/or analgesics are sold over-the-counter (OTC) in large quantities for the common cold, the evidence of effectiveness is limited. - Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients
Cochrane Systematic Reviews, 30-Jul-2014
Genital herpes is caused by herpes simplex virus 1 (HSV-1) or 2 (HSV-2). Some infected people experience outbreaks of genital herpes, typically, characterized by vesicular and erosive localized painful genital lesions. - Oral appliances for obstructive sleep apnoea
Cochrane Systematic Reviews, 26-Apr-2009
Obstructive sleep apnoea-hypopnoea (OSAH) is a syndrome characterised by recurrent episodes of partial or complete upper airway obstruction during sleep that are usually terminated by an arousal. Nasal continuous positive airway pressure (CPAP) is the pri - Oral aspirin for treating venous leg ulcers
Cochrane Systematic Reviews, 15-Feb-2016
Venous leg ulcers (VLUs) or varicose ulcers are the final stage of chronic venous insufficiency (CVI), and are the most common type of leg ulcer. The development of VLUs on ankles and lower legs can occur spontaneously or after minor trauma. The ulcers ar - Oral Astragalus (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children
Cochrane Systematic Reviews, 27-Nov-2016
Acute respiratory tract infections (ARTIs) are common in children and can involve both upper and lower airways. Many children experience frequent ARTI episodes or recurrent respiratory tract infections (RRTIs) in early life, which creates challenges for p - Oral beta-blockers for mild to moderate hypertension during pregnancy
Cochrane Systematic Reviews, 5-Jul-2012
Antihypertensives, such as beta-blockers, are used for pregnancy hypertension in the belief these will improve outcome for mother and baby. - Oral betamimetics for maintenance therapy after threatened preterm labour
Cochrane Systematic Reviews, 14-Nov-2012
Some women who have threatened to give birth prematurely, subsequently settle. They may then take oral tocolytic maintenance therapy to prevent preterm birth and to prolong gestation. - Oral budesonide for induction of remission in ulcerative colitis
Cochrane Systematic Reviews, 22-Oct-2015
Corticosteroids are first-line therapy for induction of remission in ulcerative colitis. Although corticosteroids may improve symptoms, they have significant adverse effects. Steroids which act topically, with less systemic side-effects may be more desira
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