- Antiepileptic drugs for the primary and secondary prevention of seizures after stroke
Cochrane Systematic Reviews, 7-Feb-2022
Seizures after stroke are an important clinical problem and may result in poor outcomes. The indications of antiepileptic drugs (AEDs) for seizure prophylaxis after stroke remain unclear. - Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage
Cochrane Systematic Reviews, 29-May-2013
Subarachnoid haemorrhage may result in seizures both acutely and in the longer term. The use of antiepileptic drugs (AEDs) in the primary and secondary prevention of seizures after subarachnoid haemorrhage is uncertain, and there is currently no consensus - Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis
Cochrane Systematic Reviews, 22-May-2016
Viral encephalitis is characterised by diverse clinical and epidemiological features. Seizures are an important clinical manifestation and are associated with increased mortality and morbidity. Patients may have seizures during the acute illness or they m - Antiepileptic drugs for the treatment of infants with severe myoclonic epilepsy
Cochrane Systematic Reviews, 18-May-2017
This is an updated version of the original Cochrane review published in 2015, Issue 10. - Antiepileptic drugs for treating seizures in people with brain tumours
Cochrane Systematic Reviews, 10-Aug-2011
Seizures are a common symptom of brain tumours. The mainstay of treatment for seizures is medical therapy with antiepileptic drugs. - Antiepileptics for aggression and associated impulsivity
Cochrane Systematic Reviews, 17-Feb-2010
Aggression is a major public health issue and is integral to several mental health disorders. Antiepileptic drugs may reduce aggression by acting on the central nervous system to reduce neuronal hyper-excitability associated with aggression. - Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults
Cochrane Systematic Reviews, 24-Jun-2013
Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an update of a Cochrane - Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children
Cochrane Systematic Reviews, 19-Sep-2016
This is an updated version of the original Cochrane review first published in 2008. Scoliosis surgery is often associated with substantial blood loss and potentially detrimental effects in children. Antifibrinolytic agents are often used to reduce periope - Antifibrinolytic amino acids for upper gastrointestinal bleeding in people with acute or chronic liver disease
Cochrane Systematic Reviews, 9-Jun-2015
Upper gastrointestinal bleeding is one of the most frequent causes of morbidity and mortality in the course of liver cirrhosis. People with liver disease frequently have haemostatic abnormalities such as hyperfibrinolysis. Therefore, antifibrinolytic amin - Antifibrinolytic drugs for acute traumatic injury
Cochrane Systematic Reviews, 22-May-2015
Uncontrolled bleeding is an important cause of death in trauma victims. Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may also be effective in reducing blood loss following trauma. - Antifibrinolytic drugs for treating primary postpartum haemorrhage
Cochrane Systematic Reviews, 20-Feb-2018
Postpartum haemorrhage (PPH) - heaving bleeding within the first 24 hours after giving birth - is one of the main causes of death of women after childbirth. Antifibrinolytics, primarily tranexamic acid (TXA), have been shown to reduce bleeding in surgery - Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage
Cochrane Systematic Reviews, 9-Nov-2022
Rebleeding is an important cause of death and disability in people with aneurysmal subarachnoid haemorrhage. Rebleeding is probably related to the dissolution of the blood clot at the site of the aneurysm rupture by natural fibrinolytic activity. This rev - Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions
Cochrane Systematic Reviews, 19-Apr-2019
Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease (VWD). The - Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or dental extractions
Cochrane Systematic Reviews, 2-Jul-2018
Individuals on continuous treatment with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) are at increased risk of bleeding complications during and after oral or dental procedures. Anticoagulant treatment is preferably continued at the - Antifibrinolytic therapy to reduce haemoptysis from any cause
Cochrane Systematic Reviews, 2-Nov-2016
Haemoptysis is a common pathology around the world, occurring with more frequency in low-income countries. It has different etiologies, many of which have infectious characteristics. Antifibrinolytic agents are commonly used to manage bleeding from differ - Anti‐fibrinolytic use for minimising perioperative allogeneic blood transfusion
Cochrane Systematic Reviews, 16-Mar-2011
Concerns regarding the safety of transfused blood have led to the development of a range of interventions to minimise blood loss during major surgery. Anti-fibrinolytic drugs are widely used, particularly in cardiac surgery, and previous reviews have foun - Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders
Cochrane Systematic Reviews, 15-Mar-2016
People with haematological disorders are frequently at risk of severe or life-threatening bleeding as a result of thrombocytopenia (reduced platelet count). This is despite the routine use of prophylactic platelet transfusions to prevent bleeding once the - Antifibrinolytics for heavy menstrual bleeding
Cochrane Systematic Reviews, 15-Apr-2018
Heavy menstrual bleeding (HMB) is an important physical and social problem for women. Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium. - Antifungal agents for preventing fungal infections in non‐neutropenic critically ill patients
Cochrane Systematic Reviews, 16-Jan-2016
Invasive fungal infections are important causes of morbidity and mortality among critically ill patients. Early institution of antifungal therapy is pivotal for mortality reduction. Starting a targeted antifungal therapy after culture positivity and fungi - Antifungal agents for preventing fungal infections in solid organ transplant recipients
Cochrane Systematic Reviews, 12-May-2009
Invasive fungal infections (IFIs) are important causes of morbidity and mortality in solid organ transplant recipients.
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