- Melatonin for the prevention and treatment of jet lag
Cochrane Systematic Reviews, 3-Mar-2009
Jet lag commonly affects air travellers who cross several time zones. It results from the body's internal rhythms being out of step with the day-night cycle at the destination. Melatonin is a pineal hormone that plays a central part in regulating bodily r - Melatonin for the promotion of sleep in adults in the intensive care unit
Cochrane Systematic Reviews, 3-Jan-2019
Patients in the intensive care unit (ICU) experience sleep deprivation caused by environmental disruption, such as high noise levels and 24-hour lighting, as well as increased patient care activities and invasive monitoring as part of their care. Sleep de - Melatonin for the treatment of dementia
Cochrane Systematic Reviews, 16-Feb-2011
There are a number of studies that suggest a relationship between decline of melatonin function and the symptoms of dementia. - Mentoring adolescents to prevent drug and alcohol use
Cochrane Systematic Reviews, 5-Sep-2011
Many adolescents receive mentoring. There is no systematic review if mentoring prevents alcohol and drug use. - Mesenchymal stem cells for the prevention and treatment of bronchopulmonary dysplasia in preterm infants
Cochrane Systematic Reviews, 10-Nov-2017
Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity and currently lacks efficient treatments. Mesenchymal stem/stromal cells (MSCs) have been extensively explored as a potential therapy in several preclinical and clinical settings - Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition
Cochrane Systematic Reviews, 29-Jan-2019
Recipients of allogeneic haematopoietic stem cell transplants (HSCT) can develop acute or chronic, or both forms of graft-versus-host disease (a/cGvHD), whereby immune cells of the donor attack host tissues. Steroids are the primary treatment, but patient - Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty
Cochrane Systematic Reviews, 7-Feb-2017
Chronic pain following mesh-based inguinal hernia repair is frequently reported, and has a significant impact on quality of life. Whether mesh fixation with glue can reduce chronic pain without increasing the recurrence rate is still controversial. - Mesh versus non-mesh for inguinal and femoral hernia repair
Cochrane Systematic Reviews, 10-Sep-2018
This is an update of a Cochrane Review first published in 2001. - Metal protein attenuating compounds for the treatment of Alzheimer's dementia
Cochrane Systematic Reviews, 20-Feb-2014
Alzheimer's dementia (AD) may be caused by the formation of extracellular senile plaques comprised of beta-amyloid (Aß). In vitro and mouse model studies have demonstrated that metal protein attenuating compounds (MPACs) promote the solubilisation and cle - Metalloporphyrins for treatment of unconjugated hyperbilirubinemia in neonates
Cochrane Systematic Reviews, 30-Oct-2008
Metalloporphyrins are heme analogues that inhibit heme oxygenase, the rate-limiting enzyme in the catabolism of heme to bilirubin. By preventing the formation of bilirubin, they have the potential to reduce the level of unconjugated bilirubin in neonates - Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units
Cochrane Systematic Reviews, 21-Dec-2018
Nebulizers and metered dose inhalers (MDI) have both been adapted for delivering aerosol bronchodilation to mechanically ventilated patients, but there is incomplete knowledge as to the most effective method of delivery. - Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome
Cochrane Systematic Reviews, 16-Jan-2017
Clomiphene citrate (CC) is generally considered first-line treatment in women with anovulation due to polycystic ovary syndrome (PCOS). Ovulation induction with follicle-stimulating hormone (FSH; gonadotrophins) is second-line treatment for women who do n - Metformin for endometrial hyperplasia
Cochrane Systematic Reviews, 26-Oct-2017
Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial ca - Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes
Cochrane Systematic Reviews, 16-Jul-2018
There has been considerable interest in providing antenatal dietary and lifestyle advice for women with obesity or who are overweight during pregnancy, as a strategy to limit gestational weight gain and improve maternal and infant health. However, such an - Metformin monotherapy for type 2 diabetes mellitus
Cochrane Systematic Reviews, 30-Sep-2015
Metformin is an anti-hyperglycaemic agent used for the treatment of type 2 diabetes mellitus. Type 2 diabetes may present long-term complications: micro- (retinopathy, nephropathy and neuropathy) and macrovascular (stroke, myocardial infarction and periph - Methadone for cancer pain
Cochrane Systematic Reviews, 2-Mar-2017
This is an updated review originally published in 2004 and first updated in 2007. This version includes substantial changes to bring it in line with current methodological requirements. Methadone is a synthetic opioid that presents some challenges in dose - Methadone for neuropathic pain in adults
Cochrane Systematic Reviews, 11-Jan-2019
This review replaces an earlier review, "Methadone for chronic non-cancer pain in adults". This review serves to update the original and includes only studies of neuropathic pain. Methadone belongs to a class of analgesics known as opioids, that are consi - Methadone maintenance at different dosages for opioid dependence
Cochrane Systematic Reviews, 25-Mar-2008
Methadone maintenance treatment (MMT) is a long term opiod replacement therapy, effective in the management of opiod dependence. Even if MMT at high dosage is recommended for reducing illicit opioid use and promoting longer retention in treatment, at pres - Methods for administering subcutaneous heparin during pregnancy
Cochrane Systematic Reviews, 22-Feb-2013
Pregnant women with a history of venous thromboembolism (VTE), antithrombin deficiency, or other risk factors for VTE, need heparin (unfractionated heparin (UFH) or low-molecular weight heparin (LMWH)) prophylaxis, mainly through administering subcutaneou - Methods for assessing pre-induction cervical ripening
Cochrane Systematic Reviews, 11-Jun-2015
Induction of labour is the artificial initiation of labour in a pregnant woman after the age of fetal viability but without any objective evidence of active phase labour and with intact fetal membranes. The need for induction of labour may arise due to a
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