- Retinoic acid postconsolidation therapy for high-risk neuroblastoma patients treated with autologous haematopoietic stem cell transplantation
Cochrane Systematic Reviews, 25-Aug-2017
Neuroblastoma is a rare malignant disease and mainly affects infants and very young children. The tumours mainly develop in the adrenal medullary tissue, with an abdominal mass as the most common presentation. About 50% of patients have metastatic disease - Retinoids for preventing the progression of cervical intra-epithelial neoplasia
Cochrane Systematic Reviews, 1-Jun-2016
Invasive cervical carcinoma is preceded by a precancerous phase, cervical intra-epithelial neoplasia (CIN), which can be detected on cervical smears and confirmed by colposcopy and biopsy. Moderate and severe cases of intra-epithelial neoplasia (CIN2 and - Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in women with gynaecological malignancies
Cochrane Systematic Reviews, 28-Jan-2019
This is an updated version of an original Cochrane review published in Issue 6, 2014. Pelvic lymphadenectomy is associated with significant complications including lymphocyst formation and related morbidities. Retroperitoneal drainage using suction drains - Return-to-work coordination programmes for improving return to work in workers on sick leave
Cochrane Systematic Reviews, 30-Mar-2017
To limit long-term sick leave and associated consequences, insurers, healthcare providers and employers provide programmes to facilitate disabled people's return to work. These programmes include a variety of coordinated and individualised interventions. - Revascularisation of the left subclavian artery for thoracic endovascular aortic repair
Cochrane Systematic Reviews, 27-Apr-2016
Controversy exists as to whether revascularisation of the left subclavian artery (LSA) confers improved outcomes in patients undergoing thoracic endovascular aortic repair (TEVAR). Even though preemptive revascularisation of the LSA has theoretical advant - Rheum officinale (a traditional Chinese medicine) for chronic kidney disease
Cochrane Systematic Reviews, 4-Jun-2015
Chronic kidney disease (CKD) is a major public health issue worldwide. Standard therapies to delay CKD progression include dietary protein restriction and administration of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers - Ribavirin for treating Crimean Congo haemorrhagic fever
Cochrane Systematic Reviews, 4-Jun-2018
Crimean Congo haemorrhagic fever (CCHF) is a tick-borne disease that occurs in parts of Asia, Europe and Africa. Since 2000 the infection has caused epidemics in Turkey, Iran, Russia, Uganda and Pakistan. Good-quality general supportive medical care helps - Ribavirin monotherapy for chronic hepatitis C
Cochrane Systematic Reviews, 11-Aug-2009
Hepatitis C is a major cause of liver-related morbidity and mortality. A high proportion of patients never experience symptoms. Peginterferon plus ribavirin is the recommended treatment for chronic hepatitis C. However, ribavirin monotherapy may be consid - Ribavirin plus interferon versus interferon for chronic hepatitis C
Cochrane Systematic Reviews, 10-Nov-2009
Hepatitis C is a major cause of liver-related morbidity and mortality. Standard therapy is ribavirin plus pegylated interferon to achieve undetectable level of virus in the blood, but the effect on clinical outcomes is controversial. - Ribavirin with or without alpha interferon for chronic hepatitis C
Cochrane Systematic Reviews, 20-Oct-2008
Hepatitis C is a major cause of liver-related morbidity and mortality. Ribavirin plus interferon combination therapy is presently considered the optimal treatment of interferon naive patients with chronic hepatitis C, but its role in relapsers and non-res - Rice-based oral rehydration solution for treating diarrhoea
Cochrane Systematic Reviews, 9-Nov-2009
Oral rehydration therapy is used to treat dehydration caused by diarrhoea. However the rehydration solution does not reduce stool loss or length of illness. A solution able to do this may lessen the use of ineffective diarrhoea treatments as well as impro - Rifabutin for treating pulmonary tuberculosis
Cochrane Systematic Reviews, 10-Nov-2009
Rifamycins are an essential component of modern short-course regimens for treating tuberculosis. Rifabutin has favourable pharmacokinetic and pharmacodynamic properties and is less prone to drug-drug interactions than rifampicin. It could contribute to sh - Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB
Cochrane Systematic Reviews, 28-Jun-2013
Preventing active tuberculosis (TB) from developing in people with latent tuberculosis infection (LTBI) is important for global TB control. Isoniazid (INH) for six to nine months has 60% to 90% protective efficacy, but the treatment period is long, liver - Rigid dressings versus soft dressings for transtibial amputations
Cochrane Systematic Reviews, 14-Jun-2019
Dressings are part of the routine postoperative management of people after transtibial amputation. Two types of dressings are commonly used; soft dressings (e.g. elastic bandages, crepe bandages) and rigid dressings (e.g. non-removable rigid dressings, re - Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
Cochrane Systematic Reviews, 14-Feb-2012
Riluzole is approved for the treatment of amyotrophic lateral sclerosis in most countries. Questions persist about its clinical utility because of high cost and modest efficacy. - Rimonabant for overweight or obesity
Cochrane Systematic Reviews, 2-Nov-2008
Worldwide, the prevalence of obesity and overweight in industrialized countries and in a substantial number of developing countries is increasing at an alarming rate. Rimonabant is a selective cannabinoid-1 receptor antagonist that has been investigated f - Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women
Cochrane Systematic Reviews, 24-May-2010
Osteoporosis is an abnormal reduction in bone mass and bone deterioration leading to increased fracture risk. Risedronate belongs to the bisphosphonate class of drugs which act to inhibit bone resorption by interfering with the activity of osteoclasts. - Risk of endometrial cancer in women treated with ovary-stimulating drugs for subfertility
Cochrane Systematic Reviews, 25-Mar-2017
Medical treatment for subfertility principally involves the use of ovary-stimulating agents, including selective oestrogen receptor modulators (SERMs), such as clomiphene citrate, gonadotropins, gonadotropin-releasing hormone (GnRH) agonists and antagonis - Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
Cochrane Systematic Reviews, 14-Apr-2010
Metformin is an oral anti-hyperglycemic agent that has been shown to reduce total mortality compared to other anti-hyperglycemic agents, in the treatment of type 2 diabetes mellitus. Metformin, however, is thought to increase the risk of lactic acidosis, - Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations
Cochrane Systematic Reviews, 23-Aug-2018
The presence of deleterious mutations in breast cancer 1 gene (BRCA1) or breast cancer 2 gene (BRCA2) significantly increases the risk of developing some cancers, such as breast and high-grade serous cancer (HGSC) of ovarian, tubal and peritoneal origin.
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