- Prophylactic oral betamimetics for preventing preterm labour in singleton pregnancies
Cochrane Systematic Reviews, 1-Dec-2010
Preterm birth occurs in up to 6% to 10% of all births and is the major complication of pregnancy associated with perinatal mortality and morbidity. Previous preterm delivery is a strong predictor for preterm labour, and the earlier the birth, the more lik - Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy
Cochrane Systematic Reviews, 8-Dec-2015
Twin pregnancies are associated with a high risk of neonatal mortality and morbidity due to an increased rate of preterm birth. Betamimetics can decrease contraction frequency or delay preterm birth in singleton pregnancies by 24 to 48 hours. The efficacy - Prophylactic oral/topical non‐absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants
Cochrane Systematic Reviews, 15-Oct-2015
Invasive fungal infection is an important cause of mortality and morbidity in very preterm or very low birth weight infants. Uncertainty exists about the effect of prophylactic oral/topical non-absorbed antifungals to reduce mucocutaneous colonisation and - Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage
Cochrane Systematic Reviews, 26-Apr-2019
Active management of the third stage of labour reduces the risk of postpartum blood loss (postpartum haemorrhage (PPH)), and is defined as administration of a prophylactic uterotonic, early umbilical cord clamping and controlled cord traction to facilitat - Prophylactic phototherapy for preventing jaundice in preterm or low birth weight infants
Cochrane Systematic Reviews, 30-Nov-2011
Low birth weight and premature infants are at major risk for exaggerated hyperbilirubinaemia and jaundice that can lead to bilirubin encephalopathy. Phototherapy is the most common treatment for neonatal hyperbilirubinaemia and could be most effective in - Prophylactic plasma transfusion for patients without inherited bleeding disorders or anticoagulant use undergoing non‐cardiac surgery or invasive procedures
Cochrane Systematic Reviews, 26-Nov-2019
In the absence of bleeding, plasma is commonly transfused to people prophylactically to prevent bleeding. In this context, it is transfused before operative or invasive procedures (such as liver biopsy or chest drainage tube insertion) in those considered - Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation
Cochrane Systematic Reviews, 20-Apr-2012
Platelet transfusions are used in modern clinical practice to prevent and treat bleeding in thrombocytopenic patients with bone marrow failure. Although considerable advances have been made in platelet transfusion therapy in the last 40 years, some areas - Prophylactic platelet transfusions prior to surgery for people with a low platelet count
Cochrane Systematic Reviews, 9-Sep-2018
People with thrombocytopenia often require a surgical procedure. A low platelet count is a relative contraindication to surgery due to the risk of bleeding. Platelet transfusions are used in clinical practice to prevent and treat bleeding in people with t - Prophylactic postnatal thyroid hormones for prevention of morbidity and mortality in preterm infants
Cochrane Systematic Reviews, 23-Sep-2008
Observational studies have shown an association between transiently low thyroid hormone levels in preterm infants in the first weeks of life (transient hypothyroxinaemia) and abnormal neurodevelopmental outcome. Thyroid hormone replacement might prevent t - Prophylactic protein free synthetic surfactant for preventing morbidity and mortality in preterm infants
Cochrane Systematic Reviews, 7-Jan-2010
Respiratory distress syndrome (RDS) is caused by a deficiency or dysfunction of pulmonary surfactant. A variety of surfactant products including protein free synthetic surfactant have been developed and tested in the prevention and treatment of RDS. - Prophylactic steroids for pediatric open heart surgery
Cochrane Systematic Reviews, 12-May-2017
The immune response to cardiopulmonary bypass in infants and children can lead to a series of postoperative morbidities and mortality i.e. hemodynamic instability, increased infection and arrhythmias. The systemic Inflammatory response syndrome (SIRS) tha - Prophylactic surgical ligation of patent ductus arteriosus for prevention of mortality and morbidity in extremely low birth weight infants
Cochrane Systematic Reviews, 10-May-2010
Patent ductus arteriosus (PDA) is associated with increased mortality and morbidity in preterm infants. Prophylactic indomethacin results in the reduction in significant PDA, need for surgical ligation, severe intraventricular hemorrhage and serious pulmo - Prophylactic systemic antibiotics to reduce morbidity and mortality in neonates with central venous catheters
Cochrane Systematic Reviews, 12-Apr-2010
The use of central venous catheters is recognised as a risk factor for nosocomial infection. Prophylactic antibiotics may be effective in preventing catheter-related blood stream infection in newborns but may also have the undesirable effect of promoting - Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants
Cochrane Systematic Reviews, 15-Oct-2015
Invasive fungal infection is an important cause of mortality and morbidity in very preterm and very low birth weight infants. Early diagnosis is difficult and treatment is often delayed. Systemically absorbed antifungal agents (usually azoles) are increas - Prophylactic use of ergot alkaloids in the third stage of labour
Cochrane Systematic Reviews, 6-Jun-2018
Previous research has shown that the prophylactic use of uterotonic agents in the third stage of labour reduces postpartum blood loss and moderate to severe postpartum haemorrhage (PPH). PPH is defined as a blood loss of 500 mL or more within 24 hours aft - Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors
Cochrane Systematic Reviews, 11-Mar-2020
Persistent infection with high-risk human papillomaviruses (hrHPV) types is causally linked with the development of cervical precancer and cancer. HPV types 16 and 18 cause approximately 70% of cervical cancers worldwide. - Prophylactic versus selective antibiotics for term newborn infants of mothers with risk factors for neonatal infection
Cochrane Systematic Reviews, 30-Oct-2008
Early onset bacterial infection is an important cause of morbidity and mortality in newborn infants. Various factors that increase the risk of neonatal infection have been identified. It is unclear whether asymptomatic newborn infants born to mothers with - Prophylactic versus selective blood transfusion for sickle cell anaemia during pregnancy
Cochrane Systematic Reviews, 30-Jan-2012
Sickle cells have a shorter life span than normal red blood cells. It has been suggested that pregnancy complications for women with sickle cell anaemia may be reduced by regular blood transfusions. The aim is to maintain haemoglobin at 60-70% of the norm - Prophylactic versus selective blood transfusion for sickle cell disease in pregnancy
Cochrane Systematic Reviews, 22-Dec-2016
Pregnant women with sickle cell disease (HbSS, HbSC and HbSßThal) may require blood transfusion to prevent severe anaemia or to manage potential medical complications. Preventive blood transfusion in the absence of complications starting from the early we - Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants
Cochrane Systematic Reviews, 14-Aug-2012
Surfactant therapy is effective in improving the outcome of very preterm infants. Trials have studied a wide variety of surfactant preparations used either to prevent or treat respiratory distress syndrome (RDS). In animal models, prophylactic surfactant
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