- Professional, structural and organisational interventions in primary care for reducing medication errors
Cochrane Systematic Reviews, 4-Oct-2017
Medication-related adverse events in primary care represent an important cause of hospital admissions and mortality. Adverse events could result from people experiencing adverse drug reactions (not usually preventable) or could be due to medication errors - Progestagens and anti‐progestagens for pain associated with endometriosis
Cochrane Systematic Reviews, 14-Mar-2012
Endometriosis is a chronic inflammatory condition defined by the presence of glands and stroma outside the uterine cavity. It occurs in 7% to 10% of all women of reproductive age and may present as pain or infertility. The pelvic pain may be in the form o - Progestational agents for treating threatened or established preterm labour
Cochrane Systematic Reviews, 28-Jan-2014
Prematurity is not only the leading cause of perinatal morbidity and mortality but is associated with long-term impairment. Studies of various tocolytic agents have shown mixed results with little effect in improving pregnancy duration and insufficient da - Progesterone for acute traumatic brain injury
Cochrane Systematic Reviews, 22-Dec-2016
Traumatic brain injury (TBI) is a leading cause of death and disability, and the identification of effective, inexpensive and widely practicable treatments for brain injury is of great public health importance worldwide. Progesterone is a naturally produc - Progesterone for premenstrual syndrome
Cochrane Systematic Reviews, 14-Mar-2012
About 5% of women experience severe symptoms called premenstrual syndrome (PMS), only in the two weeks before their menstrual periods. Treatment with progesterone may restore a deficiency, balance menstrual hormone levels or reduce effects of falling prog - Progesterone for preventing pre‐eclampsia and its complications
Cochrane Systematic Reviews, 18-Oct-2006
In the past, progesterone has been advocated for prevention of pre-eclampsia. Although progestogens were never widely used for this purpose in clinical practice, new hypothesis have emerged which suggest progesterone may have a role in promoting immunolog - Progesterone receptor modulators for endometriosis
Cochrane Systematic Reviews, 25-Jul-2017
Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the - Progestin‐only contraceptives: effects on weight
Cochrane Systematic Reviews, 28-Aug-2016
Progestin-only contraceptives (POCs) are appropriate for many women who cannot or should not take estrogen. POCs include injectables, intrauterine contraception, implants, and oral contraceptives. Many POCs are long-acting, cost-effective methods of preve - Progestin-only pills for contraception
Cochrane Systematic Reviews, 6-Nov-2013
The introduction of a new progestin-only oral contraceptive in Europe has renewed interest in this class of oral contraceptives. Unlike the more widely used combined oral contraceptives containing an estrogen plus progestin, these pills contain only a pro - Progestogen for preventing miscarriage in women with recurrent miscarriage of unclear etiology
Cochrane Systematic Reviews, 20-Nov-2019
Progesterone, a female sex hormone, is known to induce secretory changes in the lining of the uterus essential for successful implantation of a fertilized egg. It has been suggested that a causative factor in many cases of miscarriage may be inadequate se - Progestogen for treating threatened miscarriage
Cochrane Systematic Reviews, 6-Aug-2018
Miscarriage is a common complication encountered during pregnancy. It is defined as spontaneous pregnancy loss before 20 weeks' gestation. Progesterone's physiological role is to prepare the uterus for the implantation of the embryo, enhance uterine quies - Progestogen‐releasing intrauterine systems for heavy menstrual bleeding
Cochrane Systematic Reviews, 12-Jun-2020
Heavy menstrual bleeding (HMB) impacts the quality of life of otherwise healthy women. The perception of HMB is subjective and management depends upon, among other factors, the severity of the symptoms, a woman's age, her wish to get pregnant, and the pre - Progestogen‐releasing intrauterine systems versus other forms of reversible contraceptives for contraception
Cochrane Systematic Reviews, 19-Jul-2004
Hormonally impregnated intrauterine systems (IUSs) add a progestogen to a non-medicated contraceptive device to improve contraceptive action. - Progestogens for preventing miscarriage: a network meta‐analysis
Cochrane Systematic Reviews, 19-Apr-2021
Miscarriage, defined as the spontaneous loss of a pregnancy before 24 weeks’ gestation, is common with approximately 25% of women experiencing a miscarriage in their lifetime, and 15% to 20% of pregnancies ending in a miscarriage. Progesterone has an impo - Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical therapy)
Cochrane Systematic Reviews, 23-Nov-2020
Uterine fibroids can cause heavy menstrual bleeding. Medical treatments are considered to preserve fertility. It is unclear whether progestogens or progestogen-releasing intrauterine systems can reduce fibroid-related symptoms. This is the first update of - Progestogens with or without oestrogen for irregular uterine bleeding associated with anovulation
Cochrane Systematic Reviews, 12-Sep-2012
Irregular menstrual bleeding may arise due to exogenous sex steroids, lesions of the genital tract or be associated with anovulation. Irregular bleeding due to oligo/anovulation (previously called dysfunctional uterine bleeding or DUB) is more common at t - Prognostic models for newly‐diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta‐analysis
Cochrane Systematic Reviews, 31-Jul-2020
Chronic lymphocytic leukaemia (CLL) is the most common cancer of the lymphatic system in Western countries. Several clinical and biological factors for CLL have been identified. However, it remains unclear which of the available prognostic models combinin - Prognostic models for predicting relapse or recurrence of major depressive disorder in adults
Cochrane Systematic Reviews, 5-May-2021
Relapse (the re-emergence of depressive symptoms after some level of improvement but preceding recovery) and recurrence (onset of a new depressive episode after recovery) are common in depression, lead to worse outcomes and quality of life for patients an - Prognostic value of test(s) for O6‐methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide
Cochrane Systematic Reviews, 12-Mar-2021
Glioblastoma is an aggressive form of brain cancer. Approximately five in 100 people with glioblastoma survive for five years past diagnosis. Glioblastomas that have a particular modification to their DNA (called methylation) in a particular region (the O - Progressive resistance strength training for improving physical function in older adults
Cochrane Systematic Reviews, 8-Jul-2009
Muscle weakness in old age is associated with physical function decline. Progressive resistance strength training (PRT) exercises are designed to increase strength.
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