- PI3K/AKT/mTOR inhibitors for advanced or recurrent endometrial cancer
Cochrane Systematic Reviews, 24-Sep-2019
Endometrial cancer is one of the most common gynaecological cancers in developed countries. Treatment of advanced endometrial cancer usually involves radiotherapy, chemotherapy, endocrine therapy or a combination of these. However, survival outcomes are p - Piggy-back graft for liver transplantation
Cochrane Systematic Reviews, 8-Dec-2010
Piggy-back method of transplantation, which involves preservation of the recipient retrohepatic inferior vena cava, has been suggested as an alternative to the conventional method of liver transplantation, where the recipient retrohepatic inferior vena ca - Pilates for low back pain
Cochrane Systematic Reviews, 1-Jul-2015
Non-specific low back pain is a major health problem worldwide. Interventions based on exercises have been the most commonly used treatments for patients with this condition. Over the past few years, the Pilates method has been one of the most popular exe - Pimozide for schizophrenia or related psychoses
Cochrane Systematic Reviews, 5-Nov-2013
Pimozide, formulated in the 1960s, continues to be marketed for the care of people with schizophrenia or related psychoses such as delusional disorder. It has been associated with cardiotoxicity and sudden unexplained death. Electrocardiogram monitoring i - Pimozide for tics in Tourette's syndrome
Cochrane Systematic Reviews, 17-Feb-2009
Neuroleptic drugs with potent D-2 receptor blocking properties have been the traditional treatment for tics caused by Tourette Syndrome. Pimozide is the most studied of these. Use of these medications is declining because of concerns about side effects, a - Pin site care for preventing infections associated with external bone fixators and pins
Cochrane Systematic Reviews, 13-Nov-2013
Metal pins are used to apply skeletal traction or external fixation devices in the management of orthopaedic fractures. These percutaneous pins protrude through the skin, and the way in which they are treated after insertion may affect the incidence of pi - Pine bark (Pinus spp.) extract for treating chronic disorders
Cochrane Systematic Reviews,
Pine bark (Pinus spp.) extract is rich in bioflavonoids, predominantly proanthocyanidins, which are antioxidants. Commercially-available extract supplements are marketed for preventing or treating various chronic conditions associated with oxidative stres - Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk for the development of type 2 diabetes mellitus
Cochrane Systematic Reviews,
The term prediabetes is used to describe a population with an elevated risk of developing type 2 diabetes mellitus (T2DM). With projections of an increase in the incidence of T2DM, prevention or delay of the disease and its complications is paramount. It - Pioglitazone for type 2 diabetes mellitus
Cochrane Systematic Reviews, 10-Nov-2008
Diabetes has long been recognised as a strong, independent risk factor for cardiovascular disease, a problem which accounts for approximately 70% of all mortality in people with diabetes. Prospective studies show that compared to their non-diabetic counte - Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa
Cochrane Systematic Reviews,
Pyrethroid long-lasting insecticidal nets (LLINs) have been important in the large reductions in malaria cases in Africa, but insecticide resistance in Anopheles mosquitoes threatens their impact. Insecticide synergists may help control insecticide-resist - Piracetam for acute ischaemic stroke
Cochrane Systematic Reviews, 28-Jun-2012
Piracetam has neuroprotective and antithrombotic effects that may help to reduce death and disability in people with acute stroke. This is an update of a Cochrane Review first published in 1999, and previously updated in 2006 and 2009. - Piracetam for dementia or cognitive impairment
Cochrane Systematic Reviews, 6-Jan-2012
Piracetam is a drug that may enhance memory and other intellectual functions, but its usefulness in treating dementia is uncertain. It is, however, commonly prescribed for cognitive impairment and dementia in several countries of continental Europe. - Piracetam for fetal distress in labour
Cochrane Systematic Reviews, 9-May-2012
Piracetam is thought to promote the metabolism of brain cells when they are hypoxic. It has been used to prevent adverse effects of fetal distress. - Piracetam for reducing the incidence of painful sickle cell disease crises
Cochrane Systematic Reviews,
Sickle cell disease is one of the most common genetic disorders. Sickle cell crises in which irregular and dehydrated cells contribute to blocking of blood vessels are characterised by episodes of pain. Treatment is mainly supportive and symptomatic. In v - Pit and fissure sealants for preventing dental decay in permanent teeth
Cochrane Systematic Reviews, 28-Jul-2017
Dental sealants were introduced in the 1960s to help prevent dental caries, mainly in the pits and fissures of occlusal tooth surfaces. Sealants act to prevent bacteria growth that can lead to dental decay. Evidence suggests that fissure sealants are effe - Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of children and adolescents
Cochrane Systematic Reviews,
Most of the detected increment in dental caries among children above the age of six years and adolescents is confined to occlusal surfaces of posterior permanent molars. Dental sealants and fluoride varnishes are much used to prevent caries. As the effect - Pitavastatin for lowering lipids
Cochrane Systematic Reviews,
Pitavastatin is the newest statin on the market, and the dose-related magnitude of effect of pitavastatin on blood lipids is not known. - Placebo interventions for all clinical conditions
Cochrane Systematic Reviews, 11-Nov-2009
Placebo interventions are often claimed to substantially improve patient-reported and observer-reported outcomes in many clinical conditions, but most reports on effects of placebos are based on studies that have not randomised patients to placebo or no t - Placebo response and remission rates in randomised trials of induction and maintenance therapy for ulcerative colitis
Cochrane Systematic Reviews, 8-Sep-2017
It is important to minimize placebo rates in randomised controlled trials (RCTs) to efficiently detect treatment differences between interventions. Historically, high placebo rates have been observed in clinical trials of ulcerative colitis (UC). A better - Placental cord drainage after vaginal delivery as part of the management of the third stage of labour
Cochrane Systematic Reviews, 2-Aug-2011
Cord drainage in the third stage of labour involves unclamping the previously clamped and divided umbilical cord and allowing the blood from the placenta to drain freely into an appropriate receptacle.
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