- Plasma volume expansion for treatment of pre-eclampsia
Cochrane Systematic Reviews, 10-Nov-2009
Plasma volume is reduced amongst women with pre-eclampsia. This association has led to the suggestion that expanding the plasma volume might improve maternal and uteroplacental circulation, and so potentially improve outcome for both the woman and her bab - Platelet count, spleen length, and platelet count-to-spleen length ratio for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis
Cochrane Systematic Reviews, 25-Apr-2017
Current guidelines recommend screening of people with oesophageal varices via oesophago-gastro-duodenoscopy at the time of diagnosis of hepatic cirrhosis. This requires that people repeatedly undergo unpleasant invasive procedures with their attendant ris - Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes
Cochrane Systematic Reviews, 7-Nov-2013
During percutaneous coronary intervention (PCI), and in non-ST segment elevation acute coronary syndromes (NSTEACS), the risk of acute vessel occlusion by thrombosis is high. Glycoprotein IIb/IIIa blockers strongly inhibit platelet aggregation and may pre - Platelet rich therapies for long bone healing in adults
Cochrane Systematic Reviews, 25-May-2012
The morbidity and socioeconomic costs associated with long bone healing are considerable. Platelet-rich therapies are autologous blood products with a greater concentration of platelets than physiological whole blood. Despite promising results from a numb - Platelet-rich therapies for musculoskeletal soft tissue injuries
Cochrane Systematic Reviews, 28-Apr-2014
Platelet-rich therapies are being used increasingly in the treatment of musculoskeletal soft tissue injuries such as ligament, muscle and tendon tears and tendinopathies. These therapies can be used as the principal treatment or as an augmentation procedu - Platelet-rich-plasmapheresis for minimising peri-operative allogeneic blood transfusion
Cochrane Systematic Reviews, 15-Feb-2011
Concerns regarding the safety of transfused blood have generated considerable enthusiasm for the use of technologies intended to reduce the use of allogeneic blood (blood from an unrelated donor). Platelet-rich plasmapheresis (PRP) offers an alternative a - Platinum versus non-platinum chemotherapy regimens for small cell lung cancer
Cochrane Systematic Reviews, 31-Jul-2015
Small cell lung cancer (SCLC) is a very fast growing form of cancer and is characterised by early metastasis. As a result, chemotherapy is the mainstay of treatment. A number of different platinum-based chemotherapy regimens and non-platinum-based chemoth - Platinum-containing regimens for metastatic breast cancer
Cochrane Systematic Reviews, 23-Aug-2017
Studies have reported high tumour response rates for platinum-containing regimens in the treatment of women with metastatic breast cancer. Most of these studies were conducted prior to the 'intrinsic subtype' era, and did not specifically focus on metasta - Pleurodesis for malignant pleural effusions
Cochrane Systematic Reviews, 20-Nov-2013
Approximately half of all patients with metastatic cancer develop a malignant pleural effusion which is likely to lead to a significant reduction in quality of life secondary to symptoms such as dyspnoea and cough. The aim of pleurodesis in these patients - Plugs for containing faecal incontinence
Cochrane Systematic Reviews, 3-Jul-2015
Faecal incontinence is a distressing disorder with high social stigma. Not all people with faecal incontinence can be cured with conservative or surgical treatment and they may need to rely on containment products, such as anal plugs. - Pneumatic retinopexy versus scleral buckle for repairing simple rhegmatogenous retinal detachments
Cochrane Systematic Reviews, 1-May-2015
Rhegmatogenous retinal detachment (RRD) is a full-thickness break in the sensory retina, caused by vitreous traction on the retina. While pneumatic retinopexy, scleral buckle, and vitrectomy are the accepted surgical interventions for eyes with RRD, their - Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and X-ray defined pneumonia in children less than two years of age
Cochrane Systematic Reviews, 3-Aug-2009
Pneumonia, caused by Streptococcus pneumoniae, is a major cause of morbidity and mortality among children in low-income countries. The effectiveness of pneumococcal conjugate vaccines (PCVs) against invasive pneumococcal disease (IPD), pneumonia, and mort - Pneumococcal vaccination during pregnancy for preventing infant infection
Cochrane Systematic Reviews, 22-Jan-2015
Approximately 450,000 children worldwide die of pneumococcal infections each year. The development of bacterial resistance to antimicrobials adds to the difficulty of treatment of diseases and emphasizes the need for a preventive approach. Newborn vaccina - Pneumococcal vaccine for asthma
Cochrane Systematic Reviews, 5-Jun-2014
Infection with Streptococcus pneumoniae is an important cause of pneumonia and other serious illnesses, particularly amongst those with certain high-risk medical conditions such as asthma. Although pneumococcal vaccine is routinely advocated for people wi - Pneumococcal vaccines for children and adults with bronchiectasis
Cochrane Systematic Reviews, 5-Jun-2014
Bronchiectasis is increasingly recognized as a major cause of respiratory morbidity especially in developing countries. Even in affluent countries, bronchiectasis is increasingly seen in some community subsections (e.g. Aboriginal communities) and occurs - Pneumococcal vaccines for cystic fibrosis
Cochrane Systematic Reviews, 5-Sep-2016
Invasive pneumococcal disease is associated with significant mortality and many countries have introduced routine pneumococcal vaccination into their childhood immunisation programmes. Whilst pneumococcal disease in cystic fibrosis is uncommon, pneumococc - Pneumococcal vaccines for preventing pneumonia in chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 18-Mar-2019
People with chronic obstructive pulmonary disease (COPD) are at increased risk of pneumococcal disease, especially pneumonia, as well as acute exacerbations with associated morbidity and healthcare costs. - Pneumococcal vaccines for sickle cell disease
Cochrane Systematic Reviews, 12-Jan-2012
People with sickle cell disease are particularly susceptible to pneumococcal infection, which may be fatal. Infants (children aged up to 23 months) are at particularly high risk, but conventional polysaccharide pneumococcal vaccines may be ineffective in - Point-of-care ultrasonography for diagnosing thoracoabdominal injuries in patients with blunt trauma
Cochrane Systematic Reviews, 11-Dec-2018
Point-of-care sonography (POCS) has emerged as the screening modality of choice for suspected body trauma in many emergency departments worldwide. Its best known application is FAST (focused abdominal sonography for trauma). The technology is almost ubiqu - Point-of-use fortification of foods with micronutrient powders containing iron in children of preschool and school-age
Cochrane Systematic Reviews, 23-Nov-2017
Approximately 600 million children of preschool and school age are anaemic worldwide. It is estimated that at least half of the cases are due to iron deficiency. Point-of-use fortification of foods with micronutrient powders (MNP) has been proposed as a f
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