- Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Cochrane Systematic Reviews, 16-Feb-2018
Polycystic ovary syndrome (PCOS) is characterised by infrequent or absent ovulation, and high levels of androgens and insulin (hyperinsulinaemia). Hyperinsulinaemia occurs secondary to insulin resistance and is associated with increased risk of cardiovasc - Integrated disease management interventions for patients with chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 8-Oct-2013
In people with chronic obstructive pulmonary disease (COPD) there is considerable variation in symptoms, limitations and well-being, which often complicates medical care. To improve quality of life (QoL) and exercise tolerance, while reducing the number o - Integrated management of childhood illness (IMCI) strategy for children under five
Cochrane Systematic Reviews, 22-Jun-2016
More than 7.5 million children younger than age five living in low- and middle-income countries die every year. The World Health Organization (WHO) developed the integrated management of childhood illness (IMCI) strategy to reduce mortality and morbidity - Integrated versus non-integrated orbital implants for treating anophthalmic sockets
Cochrane Systematic Reviews, 7-Nov-2016
Anophthalmia is the absence of one or both eyes, and it can be congenital (i.e. a birth defect) or acquired later in life. There are two main types of orbital implant: integrated, whereby the implant receives a blood supply from the body that allows for t - Integrating prevention of mother-to-child HIV transmission (PMTCT) programmes with other health services for preventing HIV infection and improving HIV outcomes in developing countries
Cochrane Systematic Reviews, 10-May-2011
Every year nearly 400,000 children are infected with HIV through mother-to-child transmission (MTCT), which is responsible for more than 90% of HIV infections in children. In high-income countries, the MTCT rate is less than 1% through perinatal preventio - Integration of HIV/AIDS services with maternal, neonatal and child health, nutrition, and family planning services
Cochrane Systematic Reviews, 12-Sep-2012
The integration of HIV/AIDS and maternal, neonatal, child health and nutrition services (MNCHN), including family planning (FP) is recognized as a key strategy to reduce maternal and child mortality and control the HIV/AIDS epidemic. However, limited evid - Intensity of continuous renal replacement therapy for acute kidney injury
Cochrane Systematic Reviews, 25-Sep-2016
Acute kidney injury (AKI) is a common condition among patients in intensive care units (ICU), and is associated with substantial morbidity and mortality. Continuous renal replacement therapy (CRRT) is a blood purification technique used to treat the most - Intensity of exercise for the treatment of osteoarthritis
Cochrane Systematic Reviews, 8-Jan-2013
Therapeutic exercise is used as one modality to treat people with osteoarthritis (OA). - Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus
Cochrane Systematic Reviews, 20-Jun-2016
Clinical guidelines differ regarding their recommended blood glucose targets for patients with type 1 diabetes and recent studies on patients with type 2 diabetes suggest that aiming at very low targets can increase the risk of mortality. - Intensive versus conventional glycaemic control for treating diabetic foot ulcers
Cochrane Systematic Reviews, 12-Jan-2016
The estimated likelihood of lower limb amputation is 10 to 30 times higher amongst people with diabetes compared to those without diabetes. Of all non-traumatic amputations in people with diabetes, 85% are preceded by a foot ulcer. Foot ulceration associa - Interactive computer-based interventions for sexual health promotion
Cochrane Systematic Reviews, 4-Aug-2010
Sexual health promotion is a major public health challenge; there is huge potential for health promotion via technology such as the Internet. - Interactive computer-based interventions for weight loss or weight maintenance in overweight or obese people
Cochrane Systematic Reviews, 28-Jun-2012
The World Health Organization (WHO) estimates that the number of obese or overweight individuals worldwide will increase to 1.5 billion by 2015. Chronic diseases associated with overweight or obesity include diabetes, heart disease, hypertension and strok - Interactive Health Communication Applications for people with chronic disease
Cochrane Systematic Reviews, 22-Oct-2008
Interactive Health Communication Applications (IHCAs) are computer-based, usually web-based, information packages for patients that combine health information with at least one of social support, decision support, or behaviour change support. These are in - Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults
Cochrane Systematic Reviews, 24-Apr-2019
Effective oral hygiene is a crucial factor in maintaining good oral health, which is associated with overall health and health-related quality of life. Dental floss has been used for many years in conjunction with toothbrushing for removing dental plaque - Interferon alpha for chronic hepatitis D
Cochrane Systematic Reviews, 1-Nov-2011
Hepatitis D virus is a small defective RNA virus that requires the presence of hepatitis B virus infection to infect a person. Hepatitis D is a difficult-to-treat infection. Several clinical trials have been published on the efficacy of interferon alpha f - Interferon alpha for the adjuvant treatment of cutaneous melanoma
Cochrane Systematic Reviews, 12-Oct-2015
Interferon alpha is the only agent approved for the postoperative adjuvant treatment of high-risk cutaneous melanoma. However, the survival advantage associated with this treatment is unclear, especially in terms of overall survival. Thus, adjuvant interf - Interferon beta for secondary progressive multiple sclerosis
Cochrane Systematic Reviews, 29-Nov-2011
Therapy with either recombinant beta-1a or beta-1b interferons (IFNs) is worldwide approved for Relapsing Remitting Multiple Sclerosis (RRMS). A major unanswered question is whether this treatment is able to safely reverse or retard the progressive phase - Interferon for interferon nonresponding and relapsing patients with chronic hepatitis C
Cochrane Systematic Reviews, 14-Dec-2012
The widely-accepted treatment outcome for chronic hepatitis C is the sustained viral response (that is, no measurable viral RNA in blood six months after treatment). However, this surrogate outcome (as well as the previously employed biochemical and histo - Interleukin-1 inhibitors for acute gout
Cochrane Systematic Reviews, 27-Aug-2014
Acute gout flares cause significant pain and disability and it is important to provide quick and effective pain relief. Traditional options for managing acute flares include colchicine, non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids. - Interleukin-2 as maintenance therapy for children and adults with acute myeloid leukaemia in first complete remission
Cochrane Systematic Reviews, 3-Nov-2015
Acute myeloid leukaemia (AML) is a malignant cancer of hematopoietic stem cells. The treatment of AML consists of two treatment phases: the remission induction phase to achieve a rapid, complete remission (CR) and the consolidation phase to achieve a dura
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