- Pharmacological interventions for drug-using offenders
Cochrane Systematic Reviews, 2-Jun-2015
The review represents one in a family of four reviews focusing on a range of different interventions for drug-using offenders. This specific review considers pharmacological interventions aimed at reducing drug use or criminal activity, or both, for illic - Pharmacological interventions for epilepsy in people with intellectual disabilities
Cochrane Systematic Reviews, 2-Sep-2015
The prevalence of epilepsy among people with intellectual disabilities is much higher than in the general population. Seizures in this population are often complex and refractory to treatment and antiepileptic medication may have a profound effect upon be - Pharmacological interventions for generalised itching (not caused by systemic disease or skin lesions) in pregnancy
Cochrane Systematic Reviews, 18-Feb-2016
Generalised itching is one of the most common dermatological symptoms in pregnant women. Having itchy skin during pregnancy may be very frustrating and can lead to poor sleep, exhaustion and impaired quality of life. There is a need for a systematic revie - Pharmacological interventions for heart failure in people with chronic kidney disease
Cochrane Systematic Reviews, 19-Feb-2020
Approximately half of people with heart failure have chronic kidney disease (CKD). Pharmacological interventions for heart failure in people with CKD have the potential to reduce death (any cause) or hospitalisations for decompensated heart failure. Howev - Pharmacological interventions for hypertension in children
Cochrane Systematic Reviews, 25-Jan-2014
Hypertension is a major risk factor for stroke, coronary artery disease and kidney damage in adults. There is a paucity of data on the long-term sequelae of persistent hypertension in children, but it is known that children with hypertension have evidence - Pharmacological interventions for hypertensive emergencies
Cochrane Systematic Reviews, 12-Nov-2008
Hypertensive emergencies, marked hypertension associated with acute end-organ damage, are life-threatening conditions. Many anti-hypertensive drugs have been used in these clinical settings. The benefits and harms of such treatment and the best first-line - Pharmacological interventions for ischaemia reperfusion injury in liver resection surgery performed under vascular control
Cochrane Systematic Reviews, 11-Aug-2009
Vascular occlusion used during elective liver resection to reduce blood loss results in significant ischaemia reperfusion (IR) injury. This in turn leads to significant postoperative liver dysfunction and morbidity. Various pharmacological drugs have been - Pharmacological interventions for non-alcohol related fatty liver disease (NAFLD)
Cochrane Systematic Reviews, 12-Apr-2017
Non-alcohol related fatty liver disease (commonly called non-alcoholic fatty liver disease (NAFLD)) is liver steatosis in the absence of significant alcohol consumption, use of hepatotoxic medication, or other disorders affecting the liver such as hepatit - Pharmacological interventions for pain in children and adolescents with life-limiting conditions
Cochrane Systematic Reviews, 23-Jun-2017
Pain is one of the most common symptoms in children and young people (CYP) with life-limiting conditions (LLCs) which include a wide range of diagnoses including cancer. The current literature indicates that pain is not well managed, however the evidence - Pharmacological interventions for pain in patients with temporomandibular disorders
Cochrane Systematic Reviews, 6-Sep-2010
Temporomandibular disorders (TMD) are a group of disorders affecting the temporomandibular joints and the muscles of mastication. TMDs are treated with a wide range of drugs. The extent to which the use of these drugs is based upon evidence is unknown. - Pharmacological interventions for pain relief during orthodontic treatment
Cochrane Systematic Reviews, 20-Dec-2017
Pain is a common side effect of orthodontic treatment. It increases in proportion to the amount of force applied to the teeth, and the type of orthodontic appliance used can affect the intensity of the pain. Pain during orthodontic treatment has been show - Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults
Cochrane Systematic Reviews, 25-Feb-2020
Sickle cell disease (SCD) is a group of inherited disorders of haemoglobin (Hb) structure in a person who has inherited two mutant globin genes (one from each parent), at least one of which is always the sickle mutation. It is estimated that between 5% an - Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy
Cochrane Systematic Reviews,
Acute kidney injury (AKI) is a major comorbidity in hospitalised patients. Patients with severe AKI require continuous renal replacement therapy (CRRT) when they are haemodynamically unstable. CRRT is prescribed assuming it is delivered over 24 hours. How - Pharmacological interventions for preventing complications in idiopathic hypercalciuria
Cochrane Systematic Reviews, 15-Oct-2008
Idiopathic hypercalciuria is an inherited metabolic abnormality characterised by excessive amounts of calcium excreted into the urine in patients with normal serum levels of calcium. The morbidity of hypercalciuria is related to kidney stone disease and b - Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy
Cochrane Systematic Reviews, 31-Jul-2017
Salivary gland dysfunction is an 'umbrella' term for the presence of either xerostomia (subjective sensation of dryness), or salivary gland hypofunction (reduction in saliva production). It is a predictable side effect of radiotherapy to the head and neck - Pharmacological interventions for preventing post-traumatic stress disorder (PTSD)
Cochrane Systematic Reviews, 7-Jul-2014
Post-traumatic stress disorder (PTSD) is a debilitating disorder which, after a sufficient delay, may be diagnosed amongst individuals who respond with intense fear, helplessness or horror to traumatic events. There is some evidence that the use of pharma - Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants
Cochrane Systematic Reviews, 26-Jun-2019
Upper gastrointestinal bleeding is typically a mild, self-limiting condition that can affect both preterm and term neonates, although it can be severe particularly when associated with co-morbidities. Pharmacological interventions with a proton pump inhib - Pharmacological interventions for prevention or treatment of postoperative pain in people undergoing laparoscopic cholecystectomy
Cochrane Systematic Reviews, 28-Mar-2014
While laparoscopic cholecystectomy is generally considered less painful than open surgery, pain is one of the important reasons for delayed discharge after day-surgery and overnight stay following laparoscopic cholecystectomy. The safety and effectiveness - Pharmacological interventions for primary biliary cholangitis
Cochrane Systematic Reviews, 12-Apr-2017
Primary biliary cholangitis (previously primary biliary cirrhosis) is a chronic liver disease caused by the destruction of small intra-hepatic bile ducts resulting in stasis of bile (cholestasis), liver fibrosis, and liver cirrhosis. The optimal pharmacol - Pharmacological interventions for primary sclerosing cholangitis
Cochrane Systematic Reviews, 12-Apr-2017
Primary sclerosing cholangitis is a chronic cholestatic liver disease that is associated with both hepatobiliary and colorectal malignancies, which can result in liver cirrhosis and its complications. The optimal pharmacological treatment for patients wit
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