- Doxapram for ventilatory failure due to exacerbations of chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 1-Sep-2008
COPD is a progressive illness and in the later stages, exacerbations may lead to ventilatory failure. The combination of hypoxia and hypercapnia can lead to coma and death. Correction of these blood gas abnormalities is a medical emergency. Doxapram is a - Doxapram treatment for apnea in preterm infants
Cochrane Systematic Reviews, 25-Feb-2013
Recurrent apnea is common in preterm infants, particularly at very early gestational ages. Apnea can lead to hypoxemia and bradycardia, which may be severe enough to require resuscitation including use of positive pressure ventilation. Doxapram has been u - Doxapram versus methylxanthine for apnea in preterm infants
Cochrane Systematic Reviews, 25-Feb-2013
Recurrent apnea is common in preterm infants, particularly at very early gestational ages. These episodes of loss of effective breathing can lead to hypoxemia and bradycardia which may be severe enough to require resuscitation including use of positive pr - Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis
Cochrane Systematic Reviews, 13-Jan-2016
Onchocerciasis, also known as "river blindness," is a parasitic disease that is caused by infection from the filarial nematode (roundworm), Onchocerca volvulus. Nematodes are transmitted from person to person by blackflies of the Simulium genus, which usu - D-penicillamine for primary biliary cirrhosis
Cochrane Systematic Reviews, 16-Oct-2008
D-penicillamine is used for patients with primary biliary cirrhosis due to its hepatic copper decreasing and immunomodulatory potentials. The results from randomised clinical trials have been inconsistent. - D-penicillamine for primary sclerosing cholangitis
Cochrane Systematic Reviews, 10-Nov-2008
Primary sclerosing cholangitis is a cholestatic disease. D-penicillamine is suggested as a treatment option due to its copper reducing and immunomodulatory potential. - Drama therapy for schizophrenia or schizophrenia-like illnesses
Cochrane Systematic Reviews, 23-Apr-2008
Medication is the mainstay of treatment for schizophrenia or schizophrenia-like illnesses, but many people continue to experience symptoms in spite of medication (Johnstone 1998). In addition to medication, creative therapies, such as drama therapy may pr - Dressings and topical agents for surgical wounds healing by secondary intention
Cochrane Systematic Reviews, 7-Mar-2012
Many different wound dressings and topical applications are used to cover surgical wounds healing by secondary intention. It is not known whether these dressings heal wounds at different rates. - Dressings and topical agents for treating venous leg ulcers
Cochrane Systematic Reviews, 15-Jun-2018
Venous leg ulcers are open skin wounds on the lower leg which can be slow to heal, and are both painful and costly. The point prevalence of open venous leg ulcers in the UK is about 3 cases per 10,000 people, and many people experience recurrent episodes - Dressings for healing venous leg ulcers
Cochrane Systematic Reviews, 6-May-2014
Venous leg ulcers, sometimes called varicose or stasis ulcers, are a consequence of damage to the valves in the veins of the legs, leading to raised venous pressure. Venous ulcers are characterised by a cyclical pattern of healing and recurrence. The main - Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children
Cochrane Systematic Reviews, 19-Dec-2017
Tonic-clonic convulsions and convulsive status epilepticus (currently defined as a tonic-clonic convulsion lasting at least 30 minutes) are medical emergencies and require urgent and appropriate anticonvulsant treatment. International consensus is that an - Drug therapy for obstructive sleep apnoea in adults
Cochrane Systematic Reviews, 30-Apr-2013
The treatment of choice for moderate to severe obstructive sleep apnoea (OSA) is continuous positive airways pressure (CPAP) applied via a mask during sleep. However, this is not tolerated by all individuals and its role in mild OSA is not proven. Drug th - Drug therapy for preventing post-dural puncture headache
Cochrane Systematic Reviews, 25-Jul-2016
Post-dural (post-lumbar or post-spinal) puncture headache (PDPH) is one of the most common complications of diagnostic, therapeutic or inadvertent lumbar punctures. Many drug options have been used to prevent headache in clinical practice and have also be - Drug therapy for symptoms associated with anxiety in adult palliative care patients
Cochrane Systematic Reviews, 6-Jun-2019
This is an update of a Cochrane Review first published in 2004 (Issue 1) and previously updated in 2012 (Issue 10). Anxiety is common in palliative care patients. It can be a natural response to the complex uncertainty of having a life-limiting illness or - Drug therapy for the management of cancer-related fatigue
Cochrane Systematic Reviews, 1-Aug-2010
This review is an update of a previously published review in The Cochrane Database of Systematic Reviews (Issue 1 2008). Cancer-related fatigue (CRF) is common, under-recognised and difficult to treat. There have been studies looking at drug interventions - Drug treatment for myotonia
Cochrane Systematic Reviews, 10-May-2011
Abnormal delayed relaxation of skeletal muscles, known as myotonia, can cause disability in myotonic disorders. Sodium channel blockers, tricyclic antidepressive drugs, benzodiazepines, calcium-antagonists, taurine and prednisone may be of use in reducing - Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for peripheral arterial disease of the lower limbs
Cochrane Systematic Reviews, 3-Aug-2016
Atherosclerotic peripheral arterial disease (PAD) can lead to disabling ischemia and limb loss. Treatment modalities have included risk factor optimization through life-style modifications and medications, or operative approaches using both open and minim - Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for the treatment of in-stent restenosis of the femoropopliteal arteries
Cochrane Systematic Reviews, 9-Jan-2019
Stents are placed in the femoropopliteal arteries for numerous reasons, such as atherosclerotic disease, the need for dissection, and perforation of the arteries, and can become stenosed with the passage of time. When a stent develops a flow-limiting sten - Drug-eluting stents versus bare metal stents for angina or acute coronary syndromes
Cochrane Systematic Reviews, 20-Oct-2015
Coronary artery stents are tiny tubular devices used to 'scaffold' vessels open during percutaneous transluminal coronary angioplasty (PTCA). Restenosis (re-narrowing) of vessels treated with stents is a problem; in order to reduce restenosis, stents that - Drug-eluting stents versus bare-metal stents for acute coronary syndrome
Cochrane Systematic Reviews, 21-Aug-2017
Approximately 3.7 million people died from acute coronary syndrome worldwide in 2012. Acute coronary syndrome, also known as myocardial infarction or unstable angina pectoris, is caused by a sudden blockage of the blood supplied to the heart muscle. Percu
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