- Omega‐6 fats for the primary and secondary prevention of cardiovascular disease
Cochrane Systematic Reviews, 28-Nov-2018
Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated. - Omentoplasty for oesophagogastrostomy after oesophagectomy
Cochrane Systematic Reviews, 1-Oct-2014
Oesophagectomy followed by oesophagogastrostomy is the preferred treatment for early-stage oesophageal cancer. It carries the risk of anastomotic leakage after oesophagogastric anastomosis, which causes considerable morbidity and mortality and is one of t - Once daily long‐acting beta2‐agonists and long‐acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 4-Mar-2019
Chronic obstructive pulmonary disease (COPD) is a respiratory condition causing accumulation of mucus in the airways, cough, and breathlessness; the disease is progressive and is the fourth most common cause of death worldwide. Current treatment strategie - Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media
Cochrane Systematic Reviews, 9-Sep-2014
Acute otitis media (AOM) is a common problem in children, for which amoxicillin, with or without clavulanate, is frequently prescribed as a treatment of choice. The conventional recommendation is either three or four daily doses. However, nowadays it is f - Once versus twice daily low molecular weight heparin for the initial treatment of venous thromboembolism
Cochrane Systematic Reviews, 1-May-2015
In the initial treatment of venous thromboembolism (VTE) low molecular weight heparin (LMWH) is administered once or twice daily. A once daily treatment regimen is more convenient for the patient and may optimise home treatment. However, it is not clear w - Once-daily long-acting beta₂-agonists/inhaled corticosteroids combined inhalers versus inhaled long-acting muscarinic antagonists for people with chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 6-Aug-2018
Three classes of inhaler medication are used to manage chronic obstructive pulmonary disease (COPD): long-acting beta2-agonists (LABA); long-acting muscarinic antagonists (LAMA); and inhaled corticosteroids (ICS). To encourage patient adherence, two class - Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis
Cochrane Systematic Reviews, 4-Sep-2019
People with cystic fibrosis, who are chronically colonised with the organism Pseudomonas aeruginosa, often require multiple courses of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations. The properties of aminoglycosides - One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates
Cochrane Systematic Reviews, 6-Feb-2017
Animal studies and trials in older children and adults suggest that a 'one dose per day' regimen of gentamicin is superior to a 'multiple doses per day' regimen. - One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries in children and adolescents
Cochrane Systematic Reviews, 28-Aug-2008
Topical fluorides in the form of toothpaste, mouthrinse, varnish and gel are effective caries preventive measures. However, there is uncertainty about the relative value of these interventions. - One‐incision versus two‐incision techniques for arthroscopically assisted anterior cruciate ligament reconstruction in adults
Cochrane Systematic Reviews, 14-Dec-2017
Anterior cruciate ligament (ACL) tears are serious knee injuries that are frequently treated surgically in the form of arthroscopically assisted reconstruction with grafts from the patella or hamstrings tendons. We reviewed the evidence for the choice of - One-to-one dietary interventions undertaken in a dental setting to change dietary behaviour
Cochrane Systematic Reviews, 16-Apr-2012
The dental care setting is an appropriate place to deliver dietary assessment and advice as part of patient management. However, we do not know whether this is effective in changing dietary behaviour. - One-to-one oral hygiene advice provided in a dental setting for oral health
Cochrane Systematic Reviews, 29-Oct-2018
Effective oral hygiene measures carried out on a regular basis are vital to maintain good oral health. One-to-one oral hygiene advice (OHA) within the dental setting is often provided as a means to motivate individuals and to help achieve improved levels - Online support groups for women with breast cancer
Cochrane Systematic Reviews, 10-Mar-2017
Survival rates for women with a diagnosis of breast cancer continue to improve. However, some women may experience physical, psychological and emotional effects post diagnosis, throughout treatment and beyond. Support groups can provide opportunities for - On‐site mental health workers delivering psychological therapy and psychosocial interventions to patients in primary care: effects on the professional practice of primary care providers
Cochrane Systematic Reviews, 15-Jun-2010
Mental health problems are common in primary care and mental health workers (MHWs) are increasingly working in this setting delivering psychological therapy and psychosocial interventions to patients. In addition to treating patients directly, the introdu - Open general medical wards versus specialist psychiatric units for acute psychoses
Cochrane Systematic Reviews, 18-Jan-2012
As international healthcare policy has moved away from treating people with severe mental illness in large inpatient psychiatric institutions, beds for people with acute psychiatric disorders are being established in specialised psychiatric units in gener - Open Mesh versus non-Mesh for groin hernia repair
Cochrane Systematic Reviews, 6-Sep-2011
Inguinal hernia repair is the most frequent operation in general surgery. Until recently the standard procedure has been open musculo-aponeurotic repair using sutures under tension to close the defect but 'tension-free' repair using prosthetic mesh is bec - Open Preperitoneal Techniques versus Lichtenstein Repair for elective Inguinal Hernias
Cochrane Systematic Reviews, 7-Jun-2012
Current techniques for inguinal hernia repair show similar recurrence rates. Therefore, recurrence is no longer the main issue discussed when considering improving the current standards for groin hernia repair. Post surgical chronic pain represents a majo - Open retropubic colposuspension for urinary incontinence in women
Cochrane Systematic Reviews, 24-Jul-2017
Urinary incontinence is a common and potentially debilitating problem. Stress urinary, incontinence as the most common type of incontinence, imposes significant health and economic burdens on society and the women affected. Open retropubic colposuspension - Open surgical procedures for incisional hernias
Cochrane Systematic Reviews, 6-Dec-2010
Incisional hernias occur frequently after abdominal surgery and can cause serious complications. The choice of a type of open operative repair is controversial. Determining the type of open operative repair is controversial, as the recurrence rate may be - Open versus closed surgical exposure of canine teeth that are displaced in the roof of the mouth
Cochrane Systematic Reviews, 21-Aug-2017
Palatally displaced canines or PDCs are upper permanent canines, commonly known as 'eye' teeth, that are displaced in the roof of the mouth. This can leave unsightly gaps, cause damage to the surrounding roots (which can be so severe that neighbouring tee
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