- Non‐steroidal anti‐inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery
Cochrane Systematic Reviews, 26-Jun-2017
Cataract is a leading cause of blindness worldwide. Cataract surgery is commonly performed but can result in postoperative inflammation of the eye. Inadequately controlled inflammation increases the risk of complications. Non-steroidal anti-inflammatory d - Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing fixed orthodontic treatment
Cochrane Systematic Reviews, 5-Apr-2016
Accelerating the rate of tooth movement may help to reduce the duration of orthodontic treatment and associated unwanted effects including root resorption and enamel demineralisation. Several methods, including surgical and non-surgical adjuncts, have bee - Non‐surgical interventions for acute internal hordeolum
Cochrane Systematic Reviews, 4-Jan-2017
A hordeolum is a common, painful inflammation of the eyelid margin that is usually caused by a bacterial infection. The infection affects oil glands of the eyelid and can be either internal or external. In many cases, the lesion drains spontaneously and r - Non‐surgical interventions for eosinophilic esophagitis
Cochrane Systematic Reviews, 13-Feb-2012
People with eosinophilic esophagitis (EE) have clinical symptoms of esophageal disease, an elevated intraepithelial eosinophil count (15 in one or more high power field at endoscopy), consistent endoscopic findings and failure to respond to gastric acid s - Non‐surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis
Cochrane Systematic Reviews, 11-Feb-2015
Chronic radiation cystitis occurs a minimum of three months after completion of pelvic radiotherapy and represents a range of clinical symptoms for which there is as yet no recommended standard management. - Non‐surgical interventions for late rectal problems (proctopathy) of radiotherapy in people who have received radiotherapy to the pelvis
Cochrane Systematic Reviews, 20-Apr-2016
This is an update of a Cochrane review first published in 2002, and previously updated in 2007. Late radiation rectal problems (proctopathy) include bleeding, pain, faecal urgency, and incontinence and may develop after pelvic radiotherapy treatment for c - Non-surgical interventions for paediatric pes planus
Cochrane Systematic Reviews, 25-Sep-2012
Paediatric pes planus ('flat feet') is a common childhood condition with a reported prevalence of 14%. Flat feet can result in pain and altered gait. No optimal strategy for non-surgical management of paediatric flat feet has been identified. - Non-surgical interventions for the management of chronic pelvic pain
Cochrane Systematic Reviews, 5-Mar-2014
Chronic pelvic pain is a common and debilitating condition; its aetiology is multifactorial, involving social, psychological and biological factors. The management of chronic pelvic pain is challenging, as despite interventions involving surgery, many wom - Non‐surgical interventions for treating heavy menstrual bleeding (menorrhagia) in women with bleeding disorders
Cochrane Systematic Reviews, 10-Nov-2016
Heavy menstrual bleeding without an organic lesion is mainly due to an imbalance of the various hormones which have a regulatory effect on the menstrual cycle. Another cause of heavy menstrual bleeding with no pelvic pathology, is the presence of an acqui - Non‐surgical treatment (other than steroid injection) for carpal tunnel syndrome
Cochrane Systematic Reviews, 13-Dec-2017
Non-surgical treatment for carpal tunnel syndrome is frequently offered to those with mild to moderate symptoms. The effectiveness and duration of benefit from non-surgical treatment for carpal tunnel syndrome remain unknown. - Non‐surgical versus surgical treatment for oesophageal cancer
Cochrane Systematic Reviews, 24-Mar-2016
Oesophageal cancer is the sixth most common cause of cancer-related mortality in the world. Currently surgery is the recommended treatment modality when possible. However, it is unclear whether non-surgical treatment options is equivalent to oesophagectom - Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis
Cochrane Systematic Reviews,
Clinicians must balance the risks of bleeding and thrombosis after percutaneous coronary intervention (PCI) in people with an indication for anticoagulation. The potential of non-vitamin K antagonists (NOACs) to prevent bleeding complications is promising - Normal saline (0.9% sodium chloride) versus heparin intermittent flushing for the prevention of occlusion in long‐term central venous catheters in infants and children
Cochrane Systematic Reviews,
Guidelines and clinical practice for the prevention of complications associated with central venous catheters (CVC) around the world vary greatly. Most institutions recommend the use of heparin to prevent occlusion; there is debate, however, regarding the - Normal saline versus lower-chloride solutions for kidney transplantation
Cochrane Systematic Reviews, 4-Aug-2016
The ideal intravenous fluid for kidney transplantation has not been defined, despite the common use of normal saline during the peri-operative period. The high chloride content of normal saline is associated with an increased risk of hyperchloraemic metab - Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache
Cochrane Systematic Reviews, 4-Jan-2016
Migraine and cluster headaches are severe and disabling. Migraine affects up to 18% of women, while cluster headaches are much less common (0.2% of the population). A number of acute and prophylactic therapies are available. Hyperbaric oxygen therapy (HBO - Nortriptyline for neuropathic pain in adults
Cochrane Systematic Reviews, 29-May-2019
Antidepressants are widely used to treat chronic neuropathic pain (pain due to nerve damage), usually in doses below those at which they exert antidepressant effects. An earlier review that included all antidepressants for neuropathic pain is being replac - Notification and support for people exposed to the risk of Creutzfeldt-Jakob disease (CJD) (or other prion diseases) through medical treatment (iatrogenically)
Cochrane Systematic Reviews, 15-Feb-2011
Creutzfeldt-Jakob disease (CJD) and variant CJD (vCJD) are rare and always-fatal diseases transmissible via certain medical procedures. If a person is exposed to the disease risk through medical treatment, they may need to be notified of this to prevent t - NSAIDS or paracetamol, alone or combined with opioids, for cancer pain
Cochrane Systematic Reviews, 10-May-2011
NSAIDs are widely applied to treat cancer pain and are frequently combined with opioids in combination preparations for this purpose. However, it is unclear which agent is most clinically efficacious for relieving cancer-related pain, or even what may be - Nucleic acid and antigen detection tests for leptospirosis
Cochrane Systematic Reviews, 23-Jul-2019
Early diagnosis of leptospirosis may contribute to the effectiveness of antimicrobial therapy and early outbreak recognition. Nucleic acid and antigen detection tests have the potential for early diagnosis of leptospirosis. With this systematic review, we - Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection
Cochrane Systematic Reviews,
Transfer of more than one embryo during in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) increases multiple pregnancy rates resulting in an increased risk of maternal and perinatal morbidity. Elective single embryo transfer offers a
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