- Community-based interventions for the prevention of burns and scalds in children
Cochrane Systematic Reviews, 14-Mar-2012
Burns and scalds are a significant cause of morbidity and mortality in children. Successful counter-measures to prevent burn and scald-related injury have been identified. However, evidence indicating the successful roll-out of these counter-measures into - Community-based population-level interventions for promoting child oral health
Cochrane Systematic Reviews, 22-Dec-2016
Dental caries and gingival and periodontal disease are commonly occurring, preventable chronic conditions. Even though much is known about how to treat oral disease, currently we do not know which community-based population-level interventions are most ef - Comparative efficacy of epidural, subarachnoid, and intracerebroventricular opioids in patients with pain due to cancer
Cochrane Systematic Reviews, 29-Oct-2015
Since the 1970s, when endogenous opioids and opioid receptors were first isolated in the central nervous system, attempts have been made to optimize opioid therapy by delivering the medication centrally rather than systemically. Although the vast majority - Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders
Cochrane Systematic Reviews, 30-Sep-2015
Bone marrow failure disorders include a heterogenous group of disorders, of which myelodysplastic syndrome (MDS), forms the largest subgroup. MDS is predominantly a disease of the elderly, with many elderly people managed conservatively with regular allog - Comparison of a therapeutic-only versus prophylactic platelet transfusion policy for people with congenital or acquired bone marrow failure disorders
Cochrane Systematic Reviews, 30-Apr-2018
Bone marrow disorders encompass a group of diseases characterised by reduced production of red cells, white cells, and platelets, or defects in their function, or both. The most common bone marrow disorder is myelodysplastic syndrome. Thrombocytopenia, a - Comparison of animal-derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants
Cochrane Systematic Reviews, 14-Dec-2015
Animal-derived surfactants have been shown to have several advantages over the first generation synthetic surfactants and are the most commonly used surfactant preparations. The animal-derived surfactants in clinical use are minced or lavaged and modified - Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes
Cochrane Systematic Reviews, 26-Aug-2014
Benign Epilepsy with Centro Temporal Spikes (BECTS) is a common epilepsy syndrome with onset in childhood which almost always remits by adolescence. It is characterised by focal seizures associated with motor signs and somatosensory symptoms, at times pro - Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation
Cochrane Systematic Reviews, 17-Nov-2015
Platelet transfusions are used in modern clinical practice to prevent and treat bleeding in people who are thrombocytopenic due to bone marrow failure. Although considerable advances have been made in platelet transfusion therapy in the last 40 years, som - Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding
Cochrane Systematic Reviews, 11-Jun-2013
Treatment with proton pump inhibitors (PPIs) improves clinical outcomes in patients with peptic ulcer bleeding. However, the optimal dose and route of administration of PPIs remains controversial. - Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma
Cochrane Systematic Reviews, 25-May-2017
There are two different international standards for the treatment of early unfavourable and advanced stage Hodgkin lymphoma (HL): chemotherapy with escalated BEACOPP (bleomycin/etoposide/doxorubicin/cyclophosphamide/vincristine/procarbazine/prednisone) re - Comparison of routes for achieving parenteral access with a focus on the management of patients with Ebola virus disease
Cochrane Systematic Reviews, 22-May-2015
Dehydration is an important cause of death in patients with Ebola virus disease (EVD). Parenteral fluids are often required in patients with fluid requirements in excess of their oral intake. The peripheral intravenous route is the most commonly used meth - Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women
Cochrane Systematic Reviews, 3-Nov-2011
Pelvic floor muscle training is the most commonly recommended physical therapy treatment for women with stress urinary incontinence. It is also sometimes recommended for mixed and, less commonly, urge urinary incontinence. The supervision and content of p - Complement inhibitors for age-related macular degeneration
Cochrane Systematic Reviews, 9-Jan-2014
Given the relatively high prevalence of age-related macular degeneration (AMD) and the increased incidence of AMD as populations age, the results of trials of novel treatments are awaited with much anticipation. The complement cascade describes a series o - Complementary and miscellaneous interventions for nocturnal enuresis in children
Cochrane Systematic Reviews, 8-Nov-2011
Nocturnal enuresis (bedwetting) is a socially disruptive and stressful condition which affects around 15% to 20% of five year olds, and up to 2% of young adults. - Complex behavioural and educational interventions for nocturnal enuresis in children
Cochrane Systematic Reviews, 13-May-2008
Nocturnal enuresis (bedwetting) is a socially disruptive and stressful condition which affects around 15 to 20% of five-year olds, and up to 2% of young adults. - Compression stockings for the initial treatment of varicose veins in patients without venous ulceration
Cochrane Systematic Reviews, 6-Dec-2013
Compression hosiery or stockings are often the first line of treatment for varicose veins in people without either healed or active venous ulceration. Evidence is required to determine whether the use of compression stockings can effectively manage and tr - Compulsory community and involuntary outpatient treatment for people with severe mental disorders
Cochrane Systematic Reviews, 28-Jun-2017
It is controversial whether compulsory community treatment (CCT) for people with severe mental illness (SMI) reduces health service use, or improves clinical outcome and social functioning. - Computer-assisted versus oral-and-written dietary history taking for diabetes mellitus
Cochrane Systematic Reviews, 7-Dec-2011
Diabetes is a chronic illness characterised by insulin resistance or deficiency, resulting in elevated glycosylated haemoglobin A1c (HbA1c) levels. Diet and adherence to dietary advice is associated with lower HbA1c levels and control of disease. Dietary - Computer-assisted versus oral-and-written family history taking for identifying people with elevated risk of type 2 diabetes mellitus
Cochrane Systematic Reviews, 4-Nov-2011
Diabetes is a chronic illness characterised by insulin resistance or deficiency, resulting in elevated glycosylated haemoglobin A1c (HbA1c) levels. Because diabetes tends to run in families, the collection of data is an important tool for identifying peop - Computerized advice on drug dosage to improve prescribing practice
Cochrane Systematic Reviews, 7-Nov-2013
Maintaining therapeutic concentrations of drugs with a narrow therapeutic window is a complex task. Several computer systems have been designed to help doctors determine optimum drug dosage. Signi?cant improvements in health care could be achieved if comp
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