- Negative pressure wound therapy for treating leg ulcers
Cochrane Systematic Reviews, 2-Dec-2016
Leg ulcers are open skin wounds that occur between the ankle and the knee that can last weeks, months or even years and are a consequence of arterial or venous valvular insufficiency. Negative pressure wound therapy (NPWT) is a technology that is currentl - Negative pressure wound therapy for treating pressure ulcers
Cochrane Systematic Reviews, 2-Jun-2015
Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Negative pressure wound therapy (NPWT) is a treatment option for pressure ulcers; a clear, curren - Negative pressure wound therapy for treating surgical wounds healing by secondary intention
Cochrane Systematic Reviews, 29-May-2015
Following surgery, incisions are usually closed by fixing the edges together with sutures (stitches), staples, adhesive glue or clips. This process helps the cut edges heal together and is called 'healing by primary intention'. However, not all incised wo - Neo-adjuvant and adjuvant hormone therapy for localised and locally advanced prostate cancer
Cochrane Systematic Reviews, 3-Jun-2009
Hormone therapy for early prostate cancer has demonstrated an improvement in clinical and pathological variables, but not always an improvement in overall survival. We performed a systematic review of both adjuvant and neo-adjuvant hormone therapy combine - Neoadjuvant and adjuvant therapy for surgical resection of hepatocellular carcinoma
Cochrane Systematic Reviews, 18-Nov-2008
Hepatocellular carcinoma is a disease of great concern. Surgery is the treatment of choice, but there is still a high recurrence rate after resection. - Neo-adjuvant chemotherapy for invasive bladder cancer
Cochrane Systematic Reviews, 17-Jan-2012
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials (RCTs) involving over 3000 patients. - Neoadjuvant chemotherapy for locally advanced cervix cancer
Cochrane Systematic Reviews, 11-Feb-2015
The impact of neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer remains uncertain. - Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer
Cochrane Systematic Reviews, 11-Feb-2015
A previous systematic review found that giving neoadjuvant chemotherapy before surgery improved survival compared with radiotherapy. However, the role of neoadjuvant chemotherapy followed by surgery versus surgery alone is still unclear. - Neoadjuvant chemotherapy versus none for resectable gastric cancer
Cochrane Systematic Reviews, 29-Oct-2008
Gastric cancer is a major cause of cancer death, and many patients are only diagnosed when the cancer has reached an advanced stage. Neoadjuvant chemotherapy (NAC), that is, chemotherapy administered shortly before surgical treatment, could provide a meth - Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews
Cochrane Systematic Reviews, 19-Jun-2018
Cerebral palsy is an umbrella term that encompasses disorders of movement and posture attributed to non-progressive disturbances occurring in the developing foetal or infant brain. As there are diverse risk factors and aetiologies, no one strategy will pr - Neonatal screening for sickle cell disease
Cochrane Systematic Reviews, 29-Sep-2010
Sickle cell disease is an inherited disorder that occurs throughout the world with its highest incidence in areas of Africa where malaria is endemic. It affects up to 1 in 60 infants born in some areas of Africa. There are a number of potentially serious - Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries
Cochrane Systematic Reviews, 24-Feb-2017
Vitamin A deficiency is a major public health problem in low and middle income countries. Vitamin A supplementation in children six months of age and older has been found to be beneficial, but no effect of supplementation has been noted for children betwe - Neostigmine for reversal of neuromuscular block in paediatric patients
Cochrane Systematic Reviews, 30-Apr-2014
Residual neuromuscular block is associated with serious postoperative complications. Some anaesthesiologists use neostigmine to reverse neuromuscular blockade for all paediatric surgical patients. However, the incidence of residual neuromuscular block may - Nerve blocks for initial pain management of femoral fractures in children
Cochrane Systematic Reviews, 13-Dec-2013
Children and adolescents with femoral fractures are almost always admitted to hospital. They invariably start their hospital experience in the Emergency Department, often requiring transfer to a specialist children's hospital. They require analgesia or an - Nerve blocks or no nerve blocks for pain control after elective hip replacement (arthroplasty) surgery in adults
Cochrane Systematic Reviews, 31-Oct-2017
It is estimated that over 300,000 total hip replacements are performed each year in the USA. For European countries, the number of hip replacement procedures per 100,000 people performed in 2007 varied from less than 50 to over 250. To facilitate postoper - Nerve-sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical cancer (stage Ia2 to IIa)
Cochrane Systematic Reviews, 11-Feb-2019
Radical hysterectomy is one of the standard treatments for stage Ia2 to IIa cervical cancer. Bladder dysfunction caused by disruption of the pelvic autonomic nerves is a common complication following standard radical hysterectomy and can affect quality of - Neurally adjusted ventilatory assist compared to other forms of triggered ventilation for neonatal respiratory support
Cochrane Systematic Reviews, 19-Oct-2017
Effective synchronisation of infant respiratory effort with mechanical ventilation may allow adequate gas exchange to occur at lower peak airway pressures, potentially reducing barotrauma and volutrauma and development of air leaks and bronchopulmonary dy - Neuraminidase inhibitors for preventing and treating influenza in adults and children
Cochrane Systematic Reviews, 4-Jan-2018
Neuraminidase inhibitors (NIs) are stockpiled and recommended by public health agencies for treating and preventing seasonal and pandemic influenza. They are used clinically worldwide. - Neuraminidase inhibitors for preventing and treating influenza in children (published trials only)
Cochrane Systematic Reviews, 7-Mar-2012
During epidemics, influenza attack rates in children may exceed 40%. Options for prevention and treatment currently include the neuraminidase inhibitors zanamivir and oseltamivir. Laninamivir octanoate, the prodrug of laninamivir, is currently being devel - Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Cochrane Systematic Reviews, 15-Feb-2016
Cystic fibrosis is the most common, life-threatening, recessively inherited disease of Caucasian populations. It is a multisystem disorder caused by a mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator protein which is i
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