- Melatonin for women in pregnancy for neuroprotection of the fetus
Cochrane Systematic Reviews, 29-Mar-2016
Melatonin is an antioxidant with anti-inflammatory and anti-apoptotic effects. Animal studies have supported a fetal neuroprotective role for melatonin when administered maternally. It is important to assess whether melatonin, given to the mother, can red - Memantine for autism spectrum disorder
Cochrane Systematic Reviews, 25-Aug-2022
Autism spectrum disorder (ASD; also known as autism) is a developmental disability that begins in childhood and is typically seen in around 1% to 2% of children. It is characterised by social communication difficulties and repetitive and restricted behavi - Memantine for dementia
Cochrane Systematic Reviews, 20-Mar-2019
Memantine is a moderate affinity uncompetitive antagonist of glutamate NMDA receptors. It is licensed for use in moderate and severe Alzheimer's disease (AD); in the USA, it is also widely used off-label for mild AD. - Memantine for dementia in people with Down syndrome
Cochrane Systematic Reviews, 21-Jan-2009
Alzheimer's dementia (AD) is the most common form of dementia in people with Down Syndrome (DS). There is an understanding that an increase in L-glutamate contributes to the pathogenesis of cerebral ischemias and AD. Memantine acts as an antagonist of N-m - Membrane sweeping for induction of labour
Cochrane Systematic Reviews, 27-Feb-2020
Induction of labour involves stimulating uterine contractions artificially to promote the onset of labour. There are several pharmacological, surgical and mechanical methods used to induce labour. Membrane sweeping is a mechanical technique whereby a clin - Memory rehabilitation for people with multiple sclerosis
Cochrane Systematic Reviews, 18-Oct-2021
Problems with cognition, particularly memory, are common in people with multiple sclerosis (MS) and can affect their ability to complete daily activities and can negatively affect quality of life. Over the last few years, there has been considerable growt - Menopausal status, ultrasound and biomarker tests in combination for the diagnosis of ovarian cancer in symptomatic women
Cochrane Systematic Reviews, 26-Jul-2022
Ovarian cancer (OC) has the highest case fatality rate of all gynaecological cancers. Diagnostic delays are caused by non-specific symptoms. Existing systematic reviews have not comprehensively covered tests in current practice, not estimated accuracy sep - Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke
Cochrane Systematic Reviews, 25-May-2020
Stroke is caused by the interruption of blood flow to the brain (ischemic stroke) or the rupture of blood vessels within the brain (hemorrhagic stroke) and may lead to changes in perception, cognition, mood, speech, health-related quality of life, and fun - Mentoring adolescents to prevent drug and alcohol use
Cochrane Systematic Reviews, 5-Sep-2011
Many adolescents receive mentoring. There is no systematic review if mentoring prevents alcohol and drug use. - Mesalamine (5‐ASA) for the prevention of recurrent diverticulitis
Cochrane Systematic Reviews, 3-Oct-2017
Diverticular disease is a common condition that increases in prevalence with age. Recent theories on the pathogenesis of diverticular inflammation have implicated chronic inflammation similar to that seen in ulcerative colitis. Mesalamine, or 5-aminosalic - Mesenchymal stem cells for the prevention and treatment of bronchopulmonary dysplasia in preterm infants
Cochrane Systematic Reviews, 10-Nov-2017
Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity and currently lacks efficient treatments. Mesenchymal stem/stromal cells (MSCs) have been extensively explored as a potential therapy in several preclinical and clinical settings - Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft‐versus‐host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition
Cochrane Systematic Reviews, 30-Jan-2019
Recipients of allogeneic haematopoietic stem cell transplants (HSCT) can develop acute or chronic, or both forms of graft-versus-host disease (a/cGvHD), whereby immune cells of the donor attack host tissues. Steroids are the primary treatment, but patient - Mesh fixation techniques in primary ventral or incisional hernia repair
Cochrane Systematic Reviews, 28-May-2021
The use of a mesh in primary ventral or incisional hernia repair lowers the recurrence rate and is the accepted standard of care for larger defects. In laparoscopic primary ventral or incisional hernia repair the insertion of a mesh is indispensable. Dif - Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty
Cochrane Systematic Reviews, 7-Feb-2017
Chronic pain following mesh-based inguinal hernia repair is frequently reported, and has a significant impact on quality of life. Whether mesh fixation with glue can reduce chronic pain without increasing the recurrence rate is still controversial. - Mesh versus non‐mesh for inguinal and femoral hernia repair
Cochrane Systematic Reviews, 13-Sep-2018
This is an update of a Cochrane Review first published in 2001. - Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies
Cochrane Systematic Reviews, 16-Mar-2018
In order to overcome the low effectiveness of assisted reproductive technologies (ART) and the high incidence of multiple births, metabolomics is proposed as a non-invasive method to assess oocyte quality, embryo viability, and endometrial receptivity, an - Metal protein attenuating compounds for the treatment of Alzheimer's dementia
Cochrane Systematic Reviews, 20-Feb-2014
Alzheimer's dementia (AD) may be caused by the formation of extracellular senile plaques comprised of beta-amyloid (Aß). In vitro and mouse model studies have demonstrated that metal protein attenuating compounds (MPACs) promote the solubilisation and cle - Metal‐free materials for fixed prosthodontic restorations
Cochrane Systematic Reviews, 20-Dec-2017
Fixed prosthodontic treatment (crowns, fixed dental prostheses (FDPs), complete arch prostheses) involves the use of several different materials to replace missing tooth structure. Traditionally full metal or metal frameworks veneered with ceramic (metal- - Metalloporphyrins for treatment of unconjugated hyperbilirubinemia in neonates
Cochrane Systematic Reviews, 30-Oct-2008
Metalloporphyrins are heme analogues that inhibit heme oxygenase, the rate-limiting enzyme in the catabolism of heme to bilirubin. By preventing the formation of bilirubin, they have the potential to reduce the level of unconjugated bilirubin in neonates - Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units
Cochrane Systematic Reviews, 6-Jun-2013
Nebulizers and metered dose inhalers (MDI) have both been adapted for delivering aerosol bronchodilation to mechanically ventilated patients, but there is incomplete knowledge as to the most effective method of delivery.
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