- Methods of decreasing infection to improve outcomes after liver resections
Cochrane Systematic Reviews, 5-Oct-2011
Infections cause both morbidity and mortality in patients undergoing liver resection. Various methods have been advocated to decrease the infectious complications after liver resection. We do not know if they are of any benefit to the patient or the healt - Methods of delivering the placenta at caesarean section
Cochrane Systematic Reviews, 21-Apr-2008
Worldwide, caesarean section is the most common major operation performed on women. Some of the reported short-term morbidities include haemorrhage, postoperative fever and endometritis. The method of delivering the placenta is one procedure that may cont - Methods of intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy
Cochrane Systematic Reviews, 25-Mar-2014
Intraperitoneal local anaesthetic instillation may decrease pain in people undergoing laparoscopic cholecystectomy. However, the optimal method to administer the local anaesthetic is unknown. - Methods of milk expression for lactating women
Cochrane Systematic Reviews, 29-Sep-2016
Breastfeeding is important, however not all infants can feed at the breast and methods of expressing milk need evaluation. - Methods of preventing bacterial sepsis and wound complications after liver transplantation
Cochrane Systematic Reviews, 5-Mar-2014
Bacterial sepsis and wound complications after liver transplantation increase mortality, morbidity, or hospital stay and are likely to increase overall transplant costs. All liver transplantation patients receive antibiotic prophylaxis. This is an update - Methods of repair for obstetric anal sphincter injury
Cochrane Systematic Reviews, 10-Dec-2013
Anal sphincter injury during childbirth - obstetric anal sphincter injuries (OASIS) - are associated with significant maternal morbidity including perineal pain, dyspareunia (painful sexual intercourse) and anal incontinence, which can lead to psychologic - Methods of term labour induction for women with a previous caesarean section
Cochrane Systematic Reviews, 9-Jun-2017
Women with a prior caesarean delivery have an increased risk of uterine rupture and for women subsequently requiring induction of labour it is unclear which method is preferable to avoid adverse outcomes. This is an update of a review that was published i - Methods of vascular occlusion for elective liver resections
Cochrane Systematic Reviews, 20-Oct-2008
Vascular occlusion is used to reduce blood loss during liver resection surgery. There is considerable controversy regarding whether vascular occlusion should be used or not during elective liver resections. The method of vascular occlusion employed is als - Methods of vascular occlusion for elective liver resections
Cochrane Systematic Reviews, 21-Jan-2009
Vascular occlusion is used to reduce blood loss during liver resection surgery. Various methods of vascular occlusion have been suggested. - Methods to decrease blood loss and transfusion requirements for liver transplantation
Cochrane Systematic Reviews, 7-Dec-2011
Excessive blood loss and increased blood transfusion requirements may have significant impact on the short-term and long-term outcomes after liver transplantation. - Methods to decrease blood loss during liver resection: a network meta‐analysis
Cochrane Systematic Reviews, 31-Oct-2016
Liver resection is a major surgery with significant mortality and morbidity. Specialists have tested various methods in attempts to limit blood loss, transfusion requirements, and morbidity during elective liver resection. These methods include different - Methotrexate as a steroid sparing agent for asthma in adults
Cochrane Systematic Reviews, 27-Jul-1998
Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotrexate has attracted attention as a possible steroid sparing agent in patients with chron - Methotrexate for ankylosing spondylitis
Cochrane Systematic Reviews, 28-Feb-2013
Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown cause, characterized by sacroiliitis and spondylitis. Methotrexate (MTX), a widely used disease-modifying antirheumatic drug (DMARD), is effective for rheumatoid arthritis (RA), and - Methotrexate for high‐grade osteosarcoma in children and young adults
Cochrane Systematic Reviews, 11-May-2011
The majority of the currently used treatment protocols for osteosarcoma are based on a combination of doxorubicin, cisplatin, methotrexate (MTX) and/or ifosfamide, of which MTX seems to be one of the most active drugs. However, in the literature, this has - Methotrexate for induction of remission in refractory Crohn's disease
Cochrane Systematic Reviews, 6-Aug-2014
Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrex - Methotrexate for induction of remission in ulcerative colitis
Cochrane Systematic Reviews, 3-Oct-2014
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Corticosteroids and 5-aminosalicylates are the most commonly used therapies. However, many patients require immunosuppressive therapy for steroid-refractory and steroid-dependent disease. Me - Methotrexate for maintenance of remission in Crohn's disease
Cochrane Systematic Reviews, 26-Aug-2014
Safe and effective long-term treatments that reduce the need for corticosteroids are needed for Crohn's disease. Although purine antimetabolites are moderately effective for maintenance of remission patients often relapse despite treatment with these agen - Methotrexate for maintenance of remission in ulcerative colitis
Cochrane Systematic Reviews, 11-Aug-2015
Methotrexate, a folate antagonist, is an immunosuppressant drug that is effective for treating several inflammatory disorders including Crohn's disease. Ulcerative colitis, a related chronic inflammatory bowel disease, can be challenging to treat. T his u - Methotrexate for multiple sclerosis
Cochrane Systematic Reviews, 19-Apr-2004
Methotrexate is a potent immunosuppressant which in theory could reduce relapse rates and delay disease progression in multiple sclerosis (MS). Subsequently, clinical trials of methotrexate have been conducted in people with MS. - Methotrexate for primary biliary cirrhosis
Cochrane Systematic Reviews, 12-May-2010
Methotrexate has been used to treat patients with primary biliary cirrhosis as it possesses immunosuppressive properties. The previously prepared version of this review from 2005 showed that methotrexate seemed to significantly increase mortality in patie
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