- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including haemorrhage from oesophageal and gastrointestinal varices. Variceal haemorrhage commonly occurs in children with chronic live - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Down's syndrome occurs when a person has three, rather than two copies of chromosome 21; or the specific area of chromosome 21 implicated in causing Down's syndrome. It is the commonest congenital cause of mental disability and also leads to numerous meta - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Neuropathic pain, which is due to nerve disease or damage, represents a significant burden on people and society. It can be particularly unpleasant and achieving adequate symptom control can be difficult. Non-pharmacological methods of treatment are often - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
An intraocular lens (IOL) is a synthetic lens that is surgically implanted within the eye following removal of the crystalline lens, during cataract surgery. While all modern IOLs attenuate the transmission of ultra-violet (UV) light, some IOLs, called bl - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Foot ulcers are a disabling complication of diabetes that affect 15% to 25% of people with diabetes at some time in their lives. Phototherapy is a relatively new, non-invasive, and pain-free treatment method, which promotes the ulcer repair process throug - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
People with a low platelet count (thrombocytopenia) often require lumbar punctures or an epidural anaesthetic. Lumbar punctures can be diagnostic (haematological malignancies, subarachnoid haematoma, meningitis) or therapeutic (spinal anaesthetic, adminis - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Neonatal endotracheal intubation is a common and potentially life-saving intervention. It is a mandatory skill for neonatal trainees, but one that is difficult to master and maintain. Intubation opportunities for trainees are decreasing and success rates - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
This is an updated version of the original Cochrane Review, published in 2016, Issue 7. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Diabetes is the commonest cause of chronic kidney disease (CKD). Both conditions commonly co-exist. Glucometabolic changes and concurrent dialysis in diabetes and CKD make glucose-lowering challenging, increasing the risk of hypoglycaemia. Glucose-lowerin - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including haemorrhage from oesophageal and gastrointestinal varices. Variceal haemorrhage commonly occurs in children with chronic live - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
This review is one of a series on drugs used to treat fibromyalgia. Fibromyalgia is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue. It affects - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Down's syndrome occurs when a person has three copies of chromosome 21, or the specific area of chromosome 21 implicated in causing Down's syndrome, rather than two. It is the commonest congenital cause of mental disability and also leads to numerous meta - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Multi-vessel coronary disease in people with ST elevation myocardial infarction (STEMI) is common and is associated with worse prognosis after STEMI. Based on limited evidence, international guidelines recommend intervention on only the culprit vessel dur - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Dementia is a worldwide concern. Its global prevalence is increasing. At present, there is no medication licensed to prevent or delay the onset of dementia. Inflammation has been suggested as a key factor in dementia pathogenesis. Therefore, medications w - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
A large proportion of people with advanced cancer will experience moderate to severe pain. Tapentadol is a novel, centrally acting analgesic medicine acting at the µ-opioid receptor and inhibiting noradrenaline reuptake. The efficacy of tapentadol is stat - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Kidney transplantation is the treatment of choice for patients with end-stage kidney disease. In a previous review we concluded that the routine use of ureteric stents in kidney transplantation reduces the incidence of major urological complications (MUC) - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Endoscopic assessment of mucosal disease activity is routinely used to determine eligibility and response to therapy in clinical trials of ulcerative colitis. The operating properties of the existing endoscopic scoring indices are unclear. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Asthma guidelines aim to guide health practitioners to optimise treatment for patients to minimise symptoms, improve or maintain good lung function, and prevent acute exacerbations. The principle of asthma guidelines is based on a step-up or step-down reg - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Asthma guidelines aim to guide health practitioners to optimise treatment for patients so as to minimise symptoms, improve or maintain good lung function, and prevent acute exacerbations or flare-ups. The principle of asthma guidelines is based on a step- - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
People with hemophilia A or B with inhibitors are at high risk of bleeding complications. Infusion of bypassing agents, such as recombinant activated FVII (rFVIIa) and plasma-derived activated prothrombin complex concentrate, are suggested as alternative
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