- Mesalamine (5-ASA) for the prevention of recurrent diverticulitis
Cochrane Systematic Reviews, 3-Oct-2017
Diverticular disease is a common condition that increases in prevalence with age. Recent theories on the pathogenesis of diverticular inflammation have implicated chronic inflammation similar to that seen in ulcerative colitis. Mesalamine, or 5-aminosalic - Mesenchymal stem cells for the prevention and treatment of bronchopulmonary dysplasia in preterm infants
Cochrane Systematic Reviews, 10-Nov-2017
Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity and currently lacks efficient treatments. Mesenchymal stem/stromal cells (MSCs) have been extensively explored as a potential therapy in several preclinical and clinical settings - Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition
Cochrane Systematic Reviews, 29-Jan-2019
Recipients of allogeneic haematopoietic stem cell transplants (HSCT) can develop acute or chronic, or both forms of graft-versus-host disease (a/cGvHD), whereby immune cells of the donor attack host tissues. Steroids are the primary treatment, but patient - Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty
Cochrane Systematic Reviews, 7-Feb-2017
Chronic pain following mesh-based inguinal hernia repair is frequently reported, and has a significant impact on quality of life. Whether mesh fixation with glue can reduce chronic pain without increasing the recurrence rate is still controversial. - Mesh versus non-mesh for inguinal and femoral hernia repair
Cochrane Systematic Reviews, 10-Sep-2018
This is an update of a Cochrane Review first published in 2001. - Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies
Cochrane Systematic Reviews, 16-Mar-2018
In order to overcome the low effectiveness of assisted reproductive technologies (ART) and the high incidence of multiple births, metabolomics is proposed as a non-invasive method to assess oocyte quality, embryo viability, and endometrial receptivity, an - Metal protein attenuating compounds for the treatment of Alzheimer's dementia
Cochrane Systematic Reviews, 20-Feb-2014
Alzheimer's dementia (AD) may be caused by the formation of extracellular senile plaques comprised of beta-amyloid (Aß). In vitro and mouse model studies have demonstrated that metal protein attenuating compounds (MPACs) promote the solubilisation and cle - Metal-free materials for fixed prosthodontic restorations
Cochrane Systematic Reviews, 21-Nov-2019
Fixed prosthodontic treatment (crowns, fixed dental prostheses (FDPs), complete arch prostheses) involves the use of several different materials to replace missing tooth structure. Traditionally full metal or metal frameworks veneered with ceramic (metal- - Metalloporphyrins for treatment of unconjugated hyperbilirubinemia in neonates
Cochrane Systematic Reviews, 30-Oct-2008
Metalloporphyrins are heme analogues that inhibit heme oxygenase, the rate-limiting enzyme in the catabolism of heme to bilirubin. By preventing the formation of bilirubin, they have the potential to reduce the level of unconjugated bilirubin in neonates - Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units
Cochrane Systematic Reviews, 21-Dec-2018
Nebulizers and metered dose inhalers (MDI) have both been adapted for delivering aerosol bronchodilation to mechanically ventilated patients, but there is incomplete knowledge as to the most effective method of delivery. - Metformin added to insulin therapy for type 1 diabetes mellitus in adolescents
Cochrane Systematic Reviews, 10-Nov-2008
In adolescents with type 1 diabetes, insulin resistance likely plays a role in the deterioration of metabolic control. In type 1 diabetes, addition of metformin to insulin therapy, to improve insulin sensitivity, has been assessed in a few trials involvin - Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus
Cochrane Systematic Reviews, 15-Apr-2019
The number of people with type 2 diabetes mellitus (T2DM) is increasing worldwide. The combination of metformin and sulphonylurea (M+S) is a widely used treatment. Whether M+S shows better or worse effects in comparison with other antidiabetic medications - Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome
Cochrane Systematic Reviews, 16-Jan-2017
Clomiphene citrate (CC) is generally considered first-line treatment in women with anovulation due to polycystic ovary syndrome (PCOS). Ovulation induction with follicle-stimulating hormone (FSH; gonadotrophins) is second-line treatment for women who do n - Metformin for endometrial hyperplasia
Cochrane Systematic Reviews, 26-Oct-2017
Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial ca - Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes
Cochrane Systematic Reviews, 16-Jul-2018
There has been considerable interest in providing antenatal dietary and lifestyle advice for women with obesity or who are overweight during pregnancy, as a strategy to limit gestational weight gain and improve maternal and infant health. However, such an - Metformin monotherapy for type 2 diabetes mellitus
Cochrane Systematic Reviews, 30-Sep-2015
Metformin is an anti-hyperglycaemic agent used for the treatment of type 2 diabetes mellitus. Type 2 diabetes may present long-term complications: micro- (retinopathy, nephropathy and neuropathy) and macrovascular (stroke, myocardial infarction and periph - Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome
Cochrane Systematic Reviews, 16-Apr-2015
The use of insulin-sensitising agents, such as metformin, in women with polycystic ovary syndrome (PCOS) who are undergoing ovulation induction or in vitro fertilisation (IVF) cycles has been widely studied. Metformin reduces hyperinsulinaemia and suppres - Methadone at tapered doses for the management of opioid withdrawal
Cochrane Systematic Reviews, 20-Dec-2012
The evidence of tapered methadone's efficacy in managing opioid withdrawal has been systematically evaluated in the previous version of this review that needs to be updated - Methadone for cancer pain
Cochrane Systematic Reviews, 2-Mar-2017
This is an updated review originally published in 2004 and first updated in 2007. This version includes substantial changes to bring it in line with current methodological requirements. Methadone is a synthetic opioid that presents some challenges in dose - Methadone for chronic non-cancer pain in adults
Cochrane Systematic Reviews, 11-Jan-2019
Methadone belongs to a class of analgesics known as opioids, that are considered the cornerstone of therapy for moderate-to-severe pain due to life-threatening illnesses; however, their use in chronic non-cancer pain (CNCP) is controversial. Methadone has
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