- Meglitinide analogues for type 2 diabetes mellitus
Cochrane Systematic Reviews, 10-Nov-2008
In type 2 diabetes mellitus, impairment of insulin secretion is an important component of the disease. Meglitinide analogues are a class of oral hypoglycaemic agents that increase insulin secretion, in particular, during the early phase of insulin release - Melatonin and agomelatine for preventing seasonal affective disorder
Cochrane Systematic Reviews, 17-Jun-2019
Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly starts in autumn or winter and remits in spring. The prevalence of SAD depends on latitude and ranges from 1.5% to 9%. The predictable season - Melatonin as add‐on treatment for epilepsy
Cochrane Systematic Reviews, 11-Aug-2016
This is an updated version of the original Cochrane review published in Issue 6, 2012. - Melatonin for non-respiratory sleep disorders in visually impaired children
Cochrane Systematic Reviews, 3-Oct-2011
Exogenous melatonin helps in regulating the circadian rhythm and is widely used for the management of sleep disorders in visually impaired children. - Melatonin for preoperative and postoperative anxiety in adults
Cochrane Systematic Reviews,
Anxiety in relation to surgery is a well-known problem. Melatonin offers an alternative treatment to benzodiazepines for ameliorating this condition in the preoperative and postoperative periods. - Melatonin for the prevention and treatment of jet lag
Cochrane Systematic Reviews, 3-Mar-2009
Jet lag commonly affects air travellers who cross several time zones. It results from the body's internal rhythms being out of step with the day-night cycle at the destination. Melatonin is a pineal hormone that plays a central part in regulating bodily r - Melatonin for the promotion of sleep in adults in the intensive care unit
Cochrane Systematic Reviews, 3-Jan-2019
Patients in the intensive care unit (ICU) experience sleep deprivation caused by environmental disruption, such as high noise levels and 24-hour lighting, as well as increased patient care activities and invasive monitoring as part of their care. Sleep de - Melatonin for the treatment of dementia
Cochrane Systematic Reviews, 16-Feb-2011
There are a number of studies that suggest a relationship between decline of melatonin function and the symptoms of dementia. - Melatonin for women in pregnancy for neuroprotection of the fetus
Cochrane Systematic Reviews, 29-Mar-2016
Melatonin is an antioxidant with anti-inflammatory and anti-apoptotic effects. Animal studies have supported a fetal neuroprotective role for melatonin when administered maternally. It is important to assess whether melatonin, given to the mother, can red - Memantine for dementia
Cochrane Systematic Reviews, 19-Mar-2019
Memantine is a moderate affinity uncompetitive antagonist of glutamate NMDA receptors. It is licensed for use in moderate and severe Alzheimer's disease (AD); in the USA, it is also widely used off-label for mild AD. - Memantine for dementia in people with Down syndrome
Cochrane Systematic Reviews, 18-Nov-2008
Alzheimer's dementia (AD) is the most common form of dementia in people with Down Syndrome (DS). There is an understanding that an increase in L-glutamate contributes to the pathogenesis of cerebral ischemias and AD. Memantine acts as an antagonist of N-m - Membrane sweeping for induction of labour
Cochrane Systematic Reviews, 5-Mar-2020
Induction of labour involves stimulating uterine contractions artificially to promote the onset of labour. There are several pharmacological, surgical and mechanical methods used to induce labour. Membrane sweeping is a mechanical technique whereby a clin - Memory rehabilitation for people with multiple sclerosis
Cochrane Systematic Reviews, 22-Mar-2016
This is an update of the Cochrane review ‘Memory rehabilitation for people with multiple sclerosis’ (first published in the Cochrane Library 14 March 2012, Issue 3). Impairments in cognitive function, particularly memory, are common in people with multipl - Mental practice for treating upper extremity deficits in individuals with hemiparesis after stroke
Cochrane Systematic Reviews,
Stroke is caused by the interruption of blood flow to the brain (ischemic stroke) or the rupture of blood vessels within the brain (hemorrhagic stroke) and may lead to changes in perception, cognition, mood, speech, health-related quality of life, and fun - Mentoring adolescents to prevent drug and alcohol use
Cochrane Systematic Reviews, 5-Sep-2011
Many adolescents receive mentoring. There is no systematic review if mentoring prevents alcohol and drug use. - Mesalamine (5‐ASA) for the prevention of recurrent diverticulitis
Cochrane Systematic Reviews, 3-Oct-2017
Diverticular disease is a common condition that increases in prevalence with age. Recent theories on the pathogenesis of diverticular inflammation have implicated chronic inflammation similar to that seen in ulcerative colitis. Mesalamine, or 5-aminosalic - Mesenchymal stem cells for the prevention and treatment of bronchopulmonary dysplasia in preterm infants
Cochrane Systematic Reviews, 8-Nov-2017
Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity and currently lacks efficient treatments. Mesenchymal stem/stromal cells (MSCs) have been extensively explored as a potential therapy in several preclinical and clinical settings - Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition
Cochrane Systematic Reviews, 29-Jan-2019
Recipients of allogeneic haematopoietic stem cell transplants (HSCT) can develop acute or chronic, or both forms of graft-versus-host disease (a/cGvHD), whereby immune cells of the donor attack host tissues. Steroids are the primary treatment, but patient - Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty
Cochrane Systematic Reviews, 7-Feb-2017
Chronic pain following mesh-based inguinal hernia repair is frequently reported, and has a significant impact on quality of life. Whether mesh fixation with glue can reduce chronic pain without increasing the recurrence rate is still controversial. - Mesh versus non-mesh for inguinal and femoral hernia repair
Cochrane Systematic Reviews, 10-Sep-2018
This is an update of a Cochrane Review first published in 2001.
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