- Local cooling for relieving pain from perineal trauma sustained during childbirth
Cochrane Systematic Reviews, 9-Oct-2020
Perineal trauma is common during childbirth and may be painful. Contemporary maternity practice includes offering women numerous forms of pain relief, including the local application of cooling treatments. This Cochrane Review is an update of a review las - Local corticosteroid injection for carpal tunnel syndrome
Cochrane Systematic Reviews, 20-Oct-2008
Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness is unknown - Local corticosteroid injection versus placebo for carpal tunnel syndrome
Cochrane Systematic Reviews, 1-Feb-2023
Carpal tunnel syndrome (CTS) is a very common clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the carpal tunnel in the wrist. Direct and indirect costs of CTS are substantial, with estimated costs of two billion US - Local interventions for the management of alveolar osteitis (dry socket)
Cochrane Systematic Reviews, 26-Sep-2022
Alveolar osteitis (dry socket) is a complication of dental extractions more often involving mandibular molar teeth. It is associated with severe pain developing 2 to 3 days postoperatively with or without halitosis, a socket that may be partially or total - Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia
Cochrane Systematic Reviews, 8-Jul-2022
Peripheral arterial disease is a major health problem, and in about 1% to 2% of patients, the disease progresses to critical limb ischaemia (CLI), also known as critical limb-threatening ischaemia. In a substantial number of individuals with CLI, no effec - Local oestrogen for vaginal atrophy in postmenopausal women
Cochrane Systematic Reviews, 31-Aug-2016
Vaginal atrophy is a frequent complaint of postmenopausal women; symptoms include vaginal dryness, itching, discomfort and painful intercourse. Systemic treatment for these symptoms in the form of oral hormone replacement therapy is not always necessary. - Local opinion leaders: effects on professional practice and healthcare outcomes
Cochrane Systematic Reviews, 24-Jun-2019
Clinical practice is not always evidence-based and, therefore, may not optimise patient outcomes. Local opinion leaders (OLs) are individuals perceived as credible and trustworthy, who disseminate and implement best evidence, for instance through informal - Local versus general anaesthesia for adults undergoing pars plana vitrectomy surgery
Cochrane Systematic Reviews, 19-Sep-2016
Vitrectomy surgery is one of the commonest ophthalmic procedures performed across the world. It may be performed using general or local anaesthesia encompassing regional or topical anaesthesia depending on a number of factors, including patient suitabilit - Local versus general anaesthesia for carotid endarterectomy
Cochrane Systematic Reviews, 13-Oct-2021
Carotid endarterectomy may significantly reduce the risk of stroke in people with recently symptomatic, severe carotid artery stenosis. However, there are significant perioperative risks that may be minimised by performing the operation under local rather - Localization techniques for guided surgical excision of non‐palpable breast lesions
Cochrane Systematic Reviews, 31-Dec-2015
Breast cancer is the most common form of cancer and the second leading cause of death amongst women in Europe. Amongst five invasive cancers per 1000 women detected in screening, 2.7 were < 15 mm in diameter; and others reported that over one third of exc - Locomotor training for walking after spinal cord injury
Cochrane Systematic Reviews, 14-Nov-2012
A traumatic spinal cord injury (SCI) is a lesion of neural elements of the spinal cord that can result in any degree of sensory and motor deficit, autonomic or bowel dysfunction. Improvement of locomotor function is one of the primary goals for people wit - Long chain polyunsaturated fatty acid supplementation in infants born at term
Cochrane Systematic Reviews, 10-Mar-2017
The long chain polyunsaturated fatty acids (LCPUFA) docosahexaenoic acid (DHA) and arachidonic acid (AA) are considered essential for maturation of the developing brain, retina and other organs in newborn infants. Standard infant milk formulae are not sup - Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS
Cochrane Systematic Reviews, 17-Oct-2012
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive-aged women. Apart from infertility, women with PCOS often have other endocrine disorders, including insulin resistance, hyperinsulinaemia and hyperandrogenism. Metformin - Long versus short inspiratory times in neonates receiving mechanical ventilation
Cochrane Systematic Reviews, 20-Oct-2003
When intermittent positive pressure ventilation (IPPV) was introduced in newborn infants with hypoxic respiratory failure from hyaline membrane disease (HMD), mortality was high and air leaks problematic. This barotrauma was caused by the high peak inspir - Long‐acting beta2‐agonist in addition to tiotropium versus either tiotropium or long‐acting beta2‐agonist alone for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 22-Oct-2015
Long-acting bronchodilators, comprising long-acting beta2-agonists (LABA) and long-acting anti-muscarinic agents (LAMA, principally tiotropium), are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease (COPD). Combining - Long-acting beta2-agonists as an inhaled corticosteroid-sparing agent for chronic asthma in adults and children
Cochrane Systematic Reviews, 29-Mar-2009
The addition of a long acting beta agonist (LABA) to inhaled corticosteroid (ICS) therapy can improve asthma symptoms and reduce exacerbations. The addition of LABA may also have an ICS-sparing effect and permit a reduction in ICS maintenance dose. - Long‐acting beta2‐agonists for bronchiectasis
Cochrane Systematic Reviews, 23-Oct-2001
Symptoms of bronchiectasis include chronic productive cough, wheeze, breathlessness and recurrent infections of the lower respiratory tract. Long-acting bronchodilators are being used more frequently in the management of people with this condition. - Long-acting beta2-agonists for chronic asthma in adults and children where background therapy contains varied or no inhaled corticosteroid
Cochrane Systematic Reviews, 22-Jul-2014
Asthma is a common respiratory disease among both adults and children and short acting inhaled beta-2 agonists are used widely for 'reliever' bronchodilator therapy. Long acting beta-2 agonists (LABA) were introduced as prospective 'symptom controllers' i - Long-acting beta2-agonists for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 11-Oct-2013
Chronic obstructive pulmonary disease (COPD) is a respiratory disease that causes progressive symptoms of breathlessness, cough and mucus build-up. It is the fourth or fifth most common cause of death worldwide and is associated with significant healthcar - Long-acting beta2-agonists for poorly reversible chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 21-Nov-2012
Chronic obstructive pulmonary disease (COPD) is characterised by partially reversible airflow limitation. Many patients have little reversibility to short acting bronchodilators, but long acting bronchodilators are frequently advocated.
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