- Leukoreduction for the prevention of adverse reactions from allogeneic blood transfusion
Cochrane Systematic Reviews, 2-Dec-2015
A blood transfusion is an acute intervention, implemented to solve life and health-threatening conditions on a short-term basis. However, blood transfusions have adverse events, some of them potentially related to immune modulation or to a direct transmis - Leukotriene inhibitors for bronchiolitis in infants and young children
Cochrane Systematic Reviews, 16-Mar-2015
Bronchiolitis is an acute inflammatory illness of the bronchioles common among infants and young children. It is often caused by the respiratory syncytial virus (RSV). Management of bronchiolitis varies between clinicians, reflecting the lack of evidence - Leukotriene receptor antagonist for prolonged non‐specific cough in children
Cochrane Systematic Reviews, 19-Apr-2006
Non-specific cough is defined as non-productive cough in the absence of identifiable respiratory disease or known aetiology. It is commonly seen in paediatric practice. These children are treated with a variety of therapies including a variety of asthma m - Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children
Cochrane Systematic Reviews, 19-Oct-2015
Episodic viral wheeze (EVW) associated with viral respiratory tract infections is a common reason for pre-school children to utilise health care resources and for carers to take time away from employment. About a third of children experience a wheezing ep - Leukotriene receptor antagonists for eczema
Cochrane Systematic Reviews, 21-Oct-2018
Eczema is a common, chronic, inflammatory skin condition that is frequently associated with atopic conditions, including asthma. Leukotriene receptor antagonists (LTRAs) have a corticosteroid-sparing role in asthma, but their role in eczema remains contro - Leukotriene receptor antagonists for non‐cystic fibrosis bronchiectasis
Cochrane Systematic Reviews, 24-Apr-2000
Leukotriene receptor antagonists are a new class of drug that were initially identified for use in asthma. As they have an effect on neutrophil mediated inflammation, they may be of benefit in bronchiectasis. - Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children
Cochrane Systematic Reviews, 2-Apr-2012
Acute asthma presentation in the emergency setting frequently leads to hospital admission. Currently available treatment options include corticosteroid therapy, beta2-agonists and oxygen. Antileukotriene agents are beneficial in chronic asthma as addition - Levetiracetam add‐on for drug‐resistant focal epilepsy
Cochrane Systematic Reviews, 30-Jun-2020
Drug resistance is common in focal epilepsy. In this update, we summarised the current evidence regarding add-on levetiracetam in treating drug-resistant focal epilepsy. The original review was published in 2001 and last updated in 2012. - Levetiracetam for neuropathic pain in adults
Cochrane Systematic Reviews, 7-Jul-2014
Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. The efficacy of levetiracetam for relief of neuropathic pain has not previously been reviewed. - Levodopa for the treatment of restless legs syndrome
Cochrane Systematic Reviews, 15-Feb-2011
Levodopa plus dopamine decarboxylase inhibitor is a common treatment for restless legs syndrome (RLS). - Levomepromazine for nausea and vomiting in palliative care
Cochrane Systematic Reviews, 2-Nov-2015
This is an updated version of the original Cochrane Review published in Issue 4, 2013, on Levomepromazine for nausea and vomiting in palliative care. - Levomepromazine for schizophrenia
Cochrane Systematic Reviews, 6-Oct-2010
Levomepromazine is an 'older' typical antipsychotic medication licensed for use in schizophrenia but sparingly prescribed in the United Kingdom. - Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen
Cochrane Systematic Reviews, 21-Dec-2020
Adjuvant tamoxifen reduces the risk of breast cancer recurrence in women with oestrogen receptor-positive breast cancer. Tamoxifen also increases the risk of postmenopausal bleeding, endometrial polyps, hyperplasia, and endometrial cancer. The levonorgest - Levonorgestrel‐releasing intrauterine device (LNG‐IUD) for symptomatic endometriosis following surgery
Cochrane Systematic Reviews, 20-Dec-2021
Endometriosis is a condition characterised by the presence of ectopic deposits of endometrial-like tissue outside the uterus, usually in the pelvis. The impact of laparoscopic treatment on overall pain is uncertain and a significant proportion of women wi - Levonorgestrel‐releasing intrauterine system for endometrial hyperplasia
Cochrane Systematic Reviews, 6-Sep-2020
In the absence of treatment, endometrial hyperplasia (EH) can progress to endometrial cancer, particularly in the presence of histologic nuclear atypia. The development of EH results from exposure of the endometrium to oestrogen unopposed by progesterone. - Levothyroxine or minimally invasive therapies for benign thyroid nodules
Cochrane Systematic Reviews, 23-Jul-2014
Thyroid nodules (TN) are common in the adult population. Some physicians use suppressive levothyroxine (LT4) therapy to achieve a reduction in the number and volume of TN. In addition, minimally invasive treatments, such as percutaneous ethanol injection - LHRH agonists for adjuvant therapy of early breast cancer in premenopausal women
Cochrane Systematic Reviews, 7-Oct-2009
Approximately 60% of breast cancers amongst premenopausal women express the nuclear oestrogen receptor (ER+ breast cancer). Adjuvant endocrine therapy is an integral component of care for ER+ breast cancer, exerting its effect by reducing the availability - Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock
Cochrane Systematic Reviews, 10-Dec-2018
Sepsis and septic shock are potentially life-threatening complications of infection that are associated with high morbidity and mortality in adults and children. Fluid therapy is regarded as a crucial intervention during initial treatment of sepsis. Wheth - Lidocaine for preventing postoperative sore throat
Cochrane Systematic Reviews, 14-Jul-2015
Sore throat is a common side-effect of general anaesthesia and is reported by between 30% and 70% of patients after tracheal intubation. The likelihood of a sore throat varies with the type, diameter, and cuff pressure of the endotracheal tube used. If in - Lidocaine for reducing propofol‐induced pain on induction of anaesthesia in adults
Cochrane Systematic Reviews, 18-Feb-2016
Pain on propofol injection is an untoward effect and this condition can reduce patient satisfaction. Intravenous lidocaine injection has been commonly used to attenuate pain on propofol injection. Although many studies have reported that lidocaine was eff
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