- Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth
Cochrane Systematic Reviews, 5-May-2018
Initial resuscitation with air is well tolerated by most infants born at term. However, the optimal fractional inspired oxygen concentration (FiO2 - proportion of the breathed air that is oxygen) targeted to oxygen saturation (SpO2 - an estimate of the am - Low-fat diets for acquired hypercholesterolaemia
Cochrane Systematic Reviews, 18-Jan-2011
Hypercholesterolaemia, characterised by raised blood cholesterol levels, is not a disease itself but a metabolic derangement that often contributes to many diseases, notably cardiovascular disease. In most cases, elevated cholesterol levels are associated - Low-molecular-weight heparins for managing vaso-occlusive crises in people with sickle cell disease
Cochrane Systematic Reviews, 18-Dec-2015
Sickle cell disease is one of the most common and severe genetic disorders in the world. It can be broadly divided into two distinct clinical phenotypes characterized by either haemolysis or vaso-occlusion. Pain is the most prominent symptom of vaso-occlu - Low-molecular-weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke
Cochrane Systematic Reviews, 4-Apr-2017
Low-molecular-weight heparins (LMWHs) and heparinoids are anticoagulants that may have more powerful antithrombotic effects than standard unfractionated heparin (UFH) but a lower risk of bleeding complications. This is an update of the original Cochrane R - Loxapine for schizophrenia
Cochrane Systematic Reviews, 14-Oct-2015
Some authors have suggested that loxapine is more effective than typical antipsychotics in reducing the negative symptoms of schizophrenia, that extrapyramidal adverse effects are not usually seen at clinically effective antipsychotic doses and that it sh - Lubeluzole for acute ischaemic stroke
Cochrane Systematic Reviews, 30-Aug-2010
Experimental studies have shown that ischaemic insults cause excess release of excitatory amino acid (EAA) neurotransmitters, particularly glutamate. Glutamate re-uptake is impaired under ischaemic conditions. In preclinical models of stroke, antagonists - Lumbar supports for prevention and treatment of low back pain
Cochrane Systematic Reviews, 18-Jan-2011
Lumbar supports are used in the treatment of low-back pain patients, to prevent the onset of low-back pain (primary prevention) or to prevent recurrences of a low-back pain episode (secondary prevention). - Lumbar sympathectomy techniques for critical lower limb ischaemia due to non-reconstructable peripheral arterial disease
Cochrane Systematic Reviews, 13-Dec-2016
Critical lower limb ischaemia (CLI) is a manifestation of peripheral arterial disease (PAD) that is seen in patients with typical chronic ischaemic rest pain or patients with ischaemic skin lesions - ulcers or gangrene - for longer than 2 weeks. Critical - Lumbar sympathectomy versus prostanoids for critical limb ischaemia due to non-reconstructable peripheral arterial disease
Cochrane Systematic Reviews, 9-Apr-2018
Peripheral arterial disease (PAD) is a common circulatory problem that can lead to reduced blood flow to the limbs, which may result in critical limb ischaemia (CLI), a painful manifestation that occurs when a person is at rest. The mainstay of treatment - Lung lavage for meconium aspiration syndrome in newborn infants
Cochrane Systematic Reviews, 29-Mar-2013
Meconium aspiration syndrome (MAS) can occur when a newborn infant inhales a mixture of meconium and amniotic fluid into the lungs around the time of delivery. Other than supportive measures, little effective therapy is available. Lung lavage may be a pot - Lung protective ventilation strategy for the acute respiratory distress syndrome
Cochrane Systematic Reviews, 13-Dec-2018
Patients with acute respiratory distress syndrome and acute lung injury require mechanical ventilatory support. Acute respiratory distress syndrome and acute lung injury are further complicated by ventilator-induced lung injury. Lung protective ventilatio - Lung volume reduction surgery for diffuse emphysema
Cochrane Systematic Reviews, 12-Oct-2016
Lung volume reduction surgery (LVRS) performed to treat patients with severe diffuse emphysema was reintroduced in the nineties. Lung volume reduction surgery aims to resect damaged emphysematous lung tissue, thereby increasing elastic properties of the l - Luteal phase support for assisted reproduction cycles
Cochrane Systematic Reviews, 19-Oct-2016
Progesterone prepares the endometrium for pregnancy by stimulating proliferation in response to human chorionic gonadotropin (hCG) produced by the corpus luteum in the luteal phase of the menstrual cycle. In assisted reproduction techniques (ART), progest - Luteal phase support in assisted reproduction cycles
Cochrane Systematic Reviews, 17-Jul-2008
The aspiration of the granulosa cells that surround the oocyte and the use of gonadotropin releasing hormone agonists (GnRHa) during assisted reproduction technology (ART) treatment can interfere with the production, during the luteal phase, of progestero - Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer
Cochrane Systematic Reviews, 21-Jan-2019
Ovarian cancer is seventh most common cancer in women worldwide. Approximately 1.3% of women will be diagnosed with ovarian cancer at some point during their life time. The majority of tumours arise from surface of the ovary (epithelial). Two thirds of th - Lycopene for the prevention of prostate cancer
Cochrane Systematic Reviews, 25-Oct-2011
Prostate cancer is a common cause of death in developed countries, yet the benefits of screening for prostate cancer still remain controversial. A prostate-specific antigen (PSA) test result greater than 4 ng/mL (nanograms/millilitre) has commonly been us - Lymphadenectomy for the management of endometrial cancer
Cochrane Systematic Reviews, 2-Oct-2017
This is an update of a previous Cochrane review published in Issue 1, 2010 and updated in Issue 9, 2015. The role of lymphadenectomy in surgical management of endometrial cancer remains controversial. Lymph node metastases can be found in approximately 10 - Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation
Cochrane Systematic Reviews, 14-Mar-2019
Kidney transplantation is the optimal treatment for end-stage kidney disease. Retrieval, transport and transplant of kidney grafts causes ischaemia reperfusion injury. The current accepted standard is static cold storage (SCS) whereby the kidney is stored - Macrolide antibiotics for bronchiectasis
Cochrane Systematic Reviews, 22-Oct-2018
Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation and distortion of the smaller airways. Bacterial colonisation of the damaged airways leads to chronic cough and sputum production, often with breathlessn - Macrolide antibiotics for cystic fibrosis
Cochrane Systematic Reviews, 12-Sep-2012
Macrolide antibiotics may have a modifying role in diseases which involve airway infection and inflammation, like cystic fibrosis.
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