- Local opinion leaders: effects on professional practice and healthcare outcomes
Cochrane Systematic Reviews, 19-Jun-2019
Clinical practice is not always evidence-based and, therefore, may not optimise patient outcomes. Local opinion leaders (OLs) are individuals perceived as credible and trustworthy, who disseminate and implement best evidence, for instance through informal - Local versus general anaesthesia for adults undergoing pars plana vitrectomy surgery
Cochrane Systematic Reviews, 19-Sep-2016
Vitrectomy surgery is one of the commonest ophthalmic procedures performed across the world. It may be performed using general or local anaesthesia encompassing regional or topical anaesthesia depending on a number of factors, including patient suitabilit - Local versus general anaesthesia for carotid endarterectomy
Cochrane Systematic Reviews,
Carotid endarterectomy may significantly reduce the risk of stroke in people with recently symptomatic, severe carotid artery stenosis. However, there are significant perioperative risks that may be minimised by performing the operation under local rather - Localization techniques for guided surgical excision of non-palpable breast lesions
Cochrane Systematic Reviews, 17-Dec-2015
Breast cancer is the most common form of cancer and the second leading cause of death amongst women in Europe. Amongst five invasive cancers per 1000 women detected in screening, 2.7 were < 15 mm in diameter; and others reported that over one third of exc - Locomotor training for walking after spinal cord injury
Cochrane Systematic Reviews, 18-Oct-2012
A traumatic spinal cord injury (SCI) is a lesion of neural elements of the spinal cord that can result in any degree of sensory and motor deficit, autonomic or bowel dysfunction. Improvement of locomotor function is one of the primary goals for people wit - Long chain polyunsaturated fatty acid supplementation in infants born at term
Cochrane Systematic Reviews, 9-Mar-2017
The long chain polyunsaturated fatty acids (LCPUFA) docosahexaenoic acid (DHA) and arachidonic acid (AA) are considered essential for maturation of the developing brain, retina and other organs in newborn infants. Standard infant milk formulae are not sup - Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS
Cochrane Systematic Reviews, 15-Nov-2012
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive-aged women. Apart from infertility, women with PCOS often have other endocrine disorders, including insulin resistance, hyperinsulinaemia and hyperandrogenism. Metformin - Long versus short inspiratory times in neonates receiving mechanical ventilation
Cochrane Systematic Reviews, 11-Nov-2008
When intermittent positive pressure ventilation (IPPV) was introduced in newborn infants with hypoxic respiratory failure from hyaline membrane disease (HMD), mortality was high and air leaks problematic. This barotrauma was caused by the high peak inspir - Long-acting beta2-agonist in addition to tiotropium versus either tiotropium or long-acting beta2-agonist alone for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 21-Oct-2015
Long-acting bronchodilators, comprising long-acting beta2-agonists (LABA) and long-acting anti-muscarinic agents (LAMA, principally tiotropium), are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease (COPD). Combining - Long-acting beta2-agonists as an inhaled corticosteroid-sparing agent for chronic asthma in adults and children
Cochrane Systematic Reviews, 29-Mar-2009
The addition of a long acting beta agonist (LABA) to inhaled corticosteroid (ICS) therapy can improve asthma symptoms and reduce exacerbations. The addition of LABA may also have an ICS-sparing effect and permit a reduction in ICS maintenance dose. - Long‐acting beta2‐agonists for bronchiectasis
Cochrane Systematic Reviews, 9-Aug-2010
Symptoms of bronchiectasis include chronic productive cough, wheeze, breathlessness and recurrent infections of the lower respiratory tract. Long-acting bronchodilators are being used more frequently in the management of people with this condition. - Long-acting beta2-agonists for chronic asthma in adults and children where background therapy contains varied or no inhaled corticosteroid
Cochrane Systematic Reviews, 22-Jul-2014
Asthma is a common respiratory disease among both adults and children and short acting inhaled beta-2 agonists are used widely for 'reliever' bronchodilator therapy. Long acting beta-2 agonists (LABA) were introduced as prospective 'symptom controllers' i - Long-acting beta2-agonists for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 11-Oct-2013
Chronic obstructive pulmonary disease (COPD) is a respiratory disease that causes progressive symptoms of breathlessness, cough and mucus build-up. It is the fourth or fifth most common cause of death worldwide and is associated with significant healthcar - Long‐acting beta2‐agonists for poorly reversible chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 21-Nov-2012
Chronic obstructive pulmonary disease (COPD) is characterised by partially reversible airflow limitation. Many patients have little reversibility to short acting bronchodilators, but long acting bronchodilators are frequently advocated. - Long‐acting beta2‐agonists versus theophylline for maintenance treatment of asthma
Cochrane Systematic Reviews, 29-Mar-2009
Theophylline and long acting beta-2 agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma. They represent different classes of drug with differing side-effect profiles. - Long-acting FSH versus daily FSH for women undergoing assisted reproduction
Cochrane Systematic Reviews, 17-Feb-2016
Assisted reproduction techniques (ART), such as in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), can help subfertile couples to create a family. It is necessary to induce multiple follicles, which is achieved by follicle stimulati - Long‐acting inhaled bronchodilators for cystic fibrosis
Cochrane Systematic Reviews,
Cystic fibrosis is a life-limiting inherited condition which affects one in 2500 newborns in the UK and 70,000 children and adults worldwide. The condition is multifaceted and affects many systems in the body. The respiratory system is particularly affect - Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis
Cochrane Systematic Reviews, 24-Mar-2014
Pharmacological therapy for chronic obstructive pulmonary disease (COPD) is aimed at relieving symptoms, improving quality of life and preventing or treating exacerbations. - Long‐acting muscarinic antagonist (LAMA) plus long‐acting beta‐agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease (COPD)
Cochrane Systematic Reviews, 5-Feb-2018
Three classes of inhaler medications are used to manage chronic obstructive pulmonary disease (COPD): long-acting beta-agonists (LABA), long-acting muscarinic antagonists (LAMA), and inhaled corticosteroids (ICS). When two classes of medications are requi - Long-acting muscarinic antagonists (LAMA) added to combination long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthma
Cochrane Systematic Reviews, 21-Jan-2016
Maintenance treatment with long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) can relieve asthma symptoms and reduce the frequency of exacerbations, but there are limited treatment options for people who do not gain control on combination L
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