- Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults with asthma
Cochrane Systematic Reviews, 16-Jul-2015
Long-acting muscarinic antagonists (LAMA), a class of drugs with proven effectiveness in chronic obstructive pulmonary disease (COPD), are being considered as an add-on option for adults with asthma whose condition is uncontrolled on inhaled corticosteroi - Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus the same dose of ICS alone for adults with asthma
Cochrane Systematic Reviews, 21-Aug-2015
Despite the availability of several evidence-based therapies and non-pharmacological strategies to improve control of symptoms and prevent exacerbations of asthma, patients with asthma continue to be at risk for mortality and morbidity. - Longchain polyunsaturated fatty acid supplementation in preterm infants
Cochrane Systematic Reviews, 3-Feb-2017
Controversy exists over whether longchain polyunsaturated fatty acids (LCPUFA) are essential nutrients for preterm infants because they may not be able to synthesise sufficient amounts of LCPUFA to meet the needs of the developing brain and retina. - Long-term antibiotics for preventing recurrent urinary tract infection in children
Cochrane Systematic Reviews, 16-Sep-2019
Urinary tract infection (UTI) is common in children. Symptoms include fever, lethargy, anorexia, and vomiting. UTI is caused by Escherichia coli in over 80% of cases and treatment is a course of antibiotics. Due to acute illness caused by UTI and the risk - Long-term effects of weight-reducing diets in people with hypertension
Cochrane Systematic Reviews, 1-Mar-2016
All major guidelines for antihypertensive therapy recommend weight loss. Thus dietary interventions that aim to reduce body weight might be a useful intervention to reduce blood pressure and adverse cardiovascular events associated with hypertension. - Long-term effects of weight-reducing drugs in people with hypertension
Cochrane Systematic Reviews, 29-Feb-2016
All major guidelines on antihypertensive therapy recommend weight loss; anti-obesity drugs may be able to help in this respect. - Long-term hormone therapy for perimenopausal and postmenopausal women
Cochrane Systematic Reviews, 16-Jan-2017
Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a Cochrane review first publi - Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma
Cochrane Systematic Reviews, 1-Aug-2019
Gliomas are brain tumours arising from glial cells with an annual incidence of 4 to 11 people per 100,000. In this review we focus on gliomas with low aggressive potential in the short term, i.e. low-grade gliomas. Most people with low-grade gliomas are t - Long-term non-pharmacological weight loss interventions for adults with prediabetes
Cochrane Systematic Reviews, 11-Nov-2008
Most persons with prediabetes (impaired glucose tolerance or impaired fasting glucose) are overweight, and obesity worsens the metabolic and physiologic abnormalities associated with this condition. Prediabetes is an important risk factor for the developm - Long-term non-pharmacological weight loss interventions for adults with type 2 diabetes mellitus
Cochrane Systematic Reviews, 10-Nov-2008
Most persons with type 2 diabetes are overweight and obesity worsens the metabolic and physiologic abnormalities associated with diabetes. - Long-term opioid management for chronic noncancer pain
Cochrane Systematic Reviews, 13-Mar-2018
Opioid therapy for chronic noncancer pain (CNCP) is controversial due to concerns regarding long-term effectiveness and safety, particularly the risk of tolerance, dependence, or abuse. - Long-term pharmacotherapy for obesity and overweight
Cochrane Systematic Reviews, 2-Nov-2008
Obesity is a highly and increasingly prevalent chronic condition for which drugs are commonly prescribed to improve health. - Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis
Cochrane Systematic Reviews, 20-Sep-2010
Women with endometriosis who are treated with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) have a lower pregnancy rate compared to women with tubal factor infertility. It has been suggested that the administration of gonadotroph - Long-term proton pump inhibitor (PPI) use and the development of gastric pre-malignant lesions
Cochrane Systematic Reviews, 2-Dec-2014
Proton pump inhibitors (PPIs) are the most effective drugs to reduce gastric acid secretion. PPIs are one of the most commonly prescribed classes of medications worldwide. Apart from short-term application, maintenance therapy with PPIs is recommended and - Long-term results of laparoscopic colorectal cancer resection
Cochrane Systematic Reviews, 26-Mar-2012
Although minimally invasive surgery has been accepted for a variety of disorders, laparoscopic resection of colorectal cancer is performed by few. Concern about oncological radicality and long term outcome has limited the adoption of laparoscopic surgery - Loop diuretics for patients receiving blood transfusions
Cochrane Systematic Reviews, 16-Feb-2015
Blood transfusions are associated with significant morbidity and mortality. Prophylactic administration of loop diuretics (furosemide, bumetanide, ethacrynic acid, or torsemide) is common practice, especially among people who are at risk for circulatory o - L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis
Cochrane Systematic Reviews, 17-Jun-2019
Hepatic encephalopathy is a common complication of cirrhosis and has high associated morbidity and mortality. The condition is classified as overt if it is clinically apparent or minimal if only evident though psychometric testing. The exact pathogenesis - Losigamone add-on therapy for focal epilepsy
Cochrane Systematic Reviews, 4-Dec-2019
Epilepsy is a common neurologic disorder, affecting approximately 50 million people worldwide; nearly a third of these people have epilepsy that is not well controlled by a single antiepileptic drug (AED) and they usually require treatment with a combinat - Low bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia
Cochrane Systematic Reviews, 16-Apr-2019
Neutropenia is a potentially serious side effect of chemotherapy and a major risk factor for infection, which can be life-threatening. It has been hypothesised that a low bacterial diet (LBD) can prevent infection and (infection-related) mortality in canc - Low dialysate sodium levels for chronic haemodialysis
Cochrane Systematic Reviews, 14-Jan-2019
Cardiovascular (CV) disease is the leading cause of death in dialysis patients, and strongly associated with fluid overload and hypertension. It is plausible that low dialysate [Na+] may decrease total body sodium content, thereby reducing fluid overload
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