- Lubeluzole for acute ischaemic stroke
Cochrane Systematic Reviews, 30-Aug-2010
Experimental studies have shown that ischaemic insults cause excess release of excitatory amino acid (EAA) neurotransmitters, particularly glutamate. Glutamate re-uptake is impaired under ischaemic conditions. In preclinical models of stroke, antagonists - Lumbar supports for prevention and treatment of low back pain
Cochrane Systematic Reviews, 18-Jan-2011
Lumbar supports are used in the treatment of low-back pain patients, to prevent the onset of low-back pain (primary prevention) or to prevent recurrences of a low-back pain episode (secondary prevention). - Lumbar sympathectomy techniques for critical lower limb ischaemia due to non-reconstructable peripheral arterial disease
Cochrane Systematic Reviews, 13-Dec-2016
Critical lower limb ischaemia (CLI) is a manifestation of peripheral arterial disease (PAD) that is seen in patients with typical chronic ischaemic rest pain or patients with ischaemic skin lesions - ulcers or gangrene - for longer than 2 weeks. Critical - Lumbar sympathectomy versus prostanoids for critical limb ischaemia due to non-reconstructable peripheral arterial disease
Cochrane Systematic Reviews, 9-Apr-2018
Peripheral arterial disease (PAD) is a common circulatory problem that can lead to reduced blood flow to the limbs, which may result in critical limb ischaemia (CLI), a painful manifestation that occurs when a person is at rest. The mainstay of treatment - Lung lavage for meconium aspiration syndrome in newborn infants
Cochrane Systematic Reviews, 29-Mar-2013
Meconium aspiration syndrome (MAS) can occur when a newborn infant inhales a mixture of meconium and amniotic fluid into the lungs around the time of delivery. Other than supportive measures, little effective therapy is available. Lung lavage may be a pot - Lung protective ventilation strategy for the acute respiratory distress syndrome
Cochrane Systematic Reviews, 13-Dec-2018
Patients with acute respiratory distress syndrome and acute lung injury require mechanical ventilatory support. Acute respiratory distress syndrome and acute lung injury are further complicated by ventilator-induced lung injury. Lung protective ventilatio - Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated neonates
Cochrane Systematic Reviews,
Preterm infants and neonates with respiratory conditions commonly require intubation and conventional mechanical ventilation (CMV) to maintain airway patency and support their respiration. Whilst this therapy is often lifesaving, it simultaneously carries - Lung volume reduction surgery for diffuse emphysema
Cochrane Systematic Reviews, 12-Oct-2016
Lung volume reduction surgery (LVRS) performed to treat patients with severe diffuse emphysema was reintroduced in the nineties. Lung volume reduction surgery aims to resect damaged emphysematous lung tissue, thereby increasing elastic properties of the l - Luteal phase support for assisted reproduction cycles
Cochrane Systematic Reviews, 19-Oct-2016
Progesterone prepares the endometrium for pregnancy by stimulating proliferation in response to human chorionic gonadotropin (hCG) produced by the corpus luteum in the luteal phase of the menstrual cycle. In assisted reproduction techniques (ART), progest - Luteal phase support in assisted reproduction cycles
Cochrane Systematic Reviews, 17-Jul-2008
The aspiration of the granulosa cells that surround the oocyte and the use of gonadotropin releasing hormone agonists (GnRHa) during assisted reproduction technology (ART) treatment can interfere with the production, during the luteal phase, of progestero - Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer
Cochrane Systematic Reviews,
Ovarian cancer is seventh most common cancer in women worldwide. Approximately 1.3% of women will be diagnosed with ovarian cancer at some point during their life time. The majority of tumours arise from surface of the ovary (epithelial). Two thirds of th - Lycopene for the prevention of prostate cancer
Cochrane Systematic Reviews, 25-Oct-2011
Prostate cancer is a common cause of death in developed countries, yet the benefits of screening for prostate cancer still remain controversial. A prostate-specific antigen (PSA) test result greater than 4 ng/mL (nanograms/millilitre) has commonly been us - Lymphadenectomy for the management of endometrial cancer
Cochrane Systematic Reviews, 2-Oct-2017
This is an update of a previous Cochrane review published in Issue 1, 2010 and updated in Issue 9, 2015. The role of lymphadenectomy in surgical management of endometrial cancer remains controversial. Lymph node metastases can be found in approximately 10 - Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation
Cochrane Systematic Reviews, 14-Mar-2019
Kidney transplantation is the optimal treatment for end-stage kidney disease. Retrieval, transport and transplant of kidney grafts causes ischaemia reperfusion injury. The current accepted standard is static cold storage (SCS) whereby the kidney is stored - Macrolide antibiotics for bronchiectasis
Cochrane Systematic Reviews, 22-Oct-2018
Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation and distortion of the smaller airways. Bacterial colonisation of the damaged airways leads to chronic cough and sputum production, often with breathlessn - Macrolide antibiotics for cystic fibrosis
Cochrane Systematic Reviews, 12-Sep-2012
Macrolide antibiotics may have a modifying role in diseases which involve airway infection and inflammation, like cystic fibrosis. - Macrolides for chronic asthma
Cochrane Systematic Reviews, 17-May-2016
Asthma is a chronic disease in which inflammation of the airways causes symptomatic coughing, wheezing, and difficult breathing. The inflammation may have different underlying causes, including a reaction to infection in the lungs. Macrolides are antibiot - Macrolides for diffuse panbronchiolitis
Cochrane Systematic Reviews, 22-Jan-2015
Diffuse panbronchiolitis (DPB) is a chronic airways disease predominantly affecting East Asians. Macrolides, a class of antibiotics, have been used as the main treatment for DPB, based on evidence from retrospective and non-randomised studies. - Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults
Cochrane Systematic Reviews, 8-Dec-2017
Chancroid is a genital ulcerative disease caused by Haemophilus ducreyi. This microorganism is endemic in Africa, where it can cause up to 10% of genital ulcers. Macrolides may be an effective alternative to treat chancroid and, based on their oral admini - Macular grid laser photocoagulation for branch retinal vein occlusion
Cochrane Systematic Reviews, 11-May-2015
Branch retinal vein occlusion (BRVO) is the second most common cause of retinal vascular abnormality after diabetic retinopathy. Persistent macular oedema develops in 60% of eyes with a BRVO. Untreated, only 14% of eyes with chronic macular oedema will ha
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