- Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain
Cochrane Systematic Reviews, 1-Feb-2017
Despite multi-modal analgesic techniques, acute postoperative pain remains an unmet health need, with up to three quarters of people undergoing surgery reporting significant pain. Liposomal bupivacaine is an analgesic consisting of bupivacaine hydrochlori - Liposomal bupivacaine peripheral nerve block for the management of postoperative pain
Cochrane Systematic Reviews, 27-Mar-2018
Postoperative pain remains a significant issue with poor perioperative pain management associated with an increased risk of morbidity and mortality. Liposomal bupivacaine is an analgesic consisting of bupivacaine hydrochloride encapsulated within multiple - Lisuride for levodopa-induced complications in Parkinson's disease
Cochrane Systematic Reviews, 13-Nov-2008
Long-term levodopa therapy in Parkinson's disease is associated with the development of motor complications including abnormal involuntary movements and a shortening response to each dose (wearing off phenomenon). It is thought that dopamine agonists can - Lisuride versus bromocriptine for levodopa-induced complications in Parkinson's disease
Cochrane Systematic Reviews, 13-Nov-2008
Long-term levodopa therapy in Parkinson's disease is associated with the development of motor complications including abnormal involuntary movements and a shortening response to each dose (wearing off phenomenon). It is thought that dopamine agonists can - Lithium for maintenance treatment of mood disorders
Cochrane Systematic Reviews, 1-Nov-2008
Mood disorders are common, disabling and tend to be recurrent. They carry a high risk of suicide. Maintenance treatment, aimed at the prevention of relapse, is therefore of vital importance. Lithium has been used for some years as the mainstay of maintena - Lithium versus antidepressants in the long-term treatment of unipolar affective disorder
Cochrane Systematic Reviews, 12-May-2009
The main rationale for the use of lithium in the long-term treatment of unipolar affective disorder is its efficacy in treating bipolar affective disorder and resistant depression. However, there is considerable uncertainty about which pharmacological int - Liver resection versus other treatments for neuroendocrine tumours in patients with resectable liver metastases
Cochrane Systematic Reviews, 15-Feb-2009
Neuroendocrine tumours are tumours of cells, which possess secretory granules and originate from the neuroectoderm. While liver resection is generally advocated in patients with resectable liver metastases, recent studies have shown good survival in patie - Lobeline for smoking cessation
Cochrane Systematic Reviews, 15-Feb-2012
Lobeline is a partial nicotine agonist, which has been used in a variety of commercially available preparations to help stop smoking. - Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity
Cochrane Systematic Reviews, 7-Dec-2011
Screening examinations for retinopathy of prematurity (ROP) are performed routinely in the neonatal intensive care unit and are a recognised cause of pain in the newborn. - Local anaesthetic nerve block for pain management in labour
Cochrane Systematic Reviews, 25-Sep-2015
Local anaesthetic nerve block is an important modality for pain management in labour. Pudendal and paracervical block (PCB) are most commonly performed local anaesthetic nerve blocks which have been used for decades. - Local anaesthetic sympathetic blockade for complex regional pain syndrome
Cochrane Systematic Reviews, 28-Jul-2016
This review is an update of a previously published review in the Cochrane Database of Systematic Reviews, 2005, Issue 4 (and last updated in the Cochrane Database of Systematic Reviews, 2013 issue 8), on local anaesthetic blockade (LASB) of the sympatheti - Local anaesthetic wound infiltration and abdominal nerves block during caesarean section for postoperative pain relief
Cochrane Systematic Reviews, 6-May-2009
Caesarean section delivery is becoming more frequent. Childbirth is an emotion-filled event and the mother needs to bond with her newborn baby as early as possible. Any intervention that leads to improvement in pain relief is worthy of investigation. Loca - Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children
Cochrane Systematic Reviews, 25-Feb-2019
Regional anaesthesia may reduce the rate of persistent postoperative pain (PPP), a frequent and debilitating condition. This review was originally published in 2012 and updated in 2017. - Local cooling for relieving pain from perineal trauma sustained during childbirth
Cochrane Systematic Reviews, 26-Mar-2012
Perineal trauma is common during childbirth and may be painful. Contemporary maternity practice includes offering women numerous forms of pain relief, including the local application of cooling treatments. - Local corticosteroid injection for carpal tunnel syndrome
Cochrane Systematic Reviews, 20-Oct-2008
Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness is unknown - Local interventions for the management of alveolar osteitis (dry socket)
Cochrane Systematic Reviews, 13-Nov-2012
Alveolar osteitis (dry socket) is a complication of dental extractions and occurs more commonly in extractions involving mandibular molar teeth. It is associated with severe pain developing 2 to 3 days postoperatively, a socket that may be partially or to - Local intramuscular transplantation of autologous mononuclear cells for critical lower limb ischaemia
Cochrane Systematic Reviews, 16-Dec-2014
Peripheral arterial disease is a major health problem, and in about 1% to 2% of patients the disease progresses to critical limb ischaemia (CLI). In a substantial number of patients with CLI, no effective treatment option other than amputation is availabl - Local oestrogen for vaginal atrophy in postmenopausal women
Cochrane Systematic Reviews, 7-Nov-2016
Vaginal atrophy is a frequent complaint of postmenopausal women; symptoms include vaginal dryness, itching, discomfort and painful intercourse. Systemic treatment for these symptoms in the form of oral hormone replacement therapy is not always necessary. - Local opinion leaders: effects on professional practice and healthcare outcomes
Cochrane Systematic Reviews, 19-Jun-2019
Clinical practice is not always evidence-based and, therefore, may not optimise patient outcomes. Local opinion leaders (OLs) are individuals perceived as credible and trustworthy, who disseminate and implement best evidence, for instance through informal - Local versus general anaesthesia for adults undergoing pars plana vitrectomy surgery
Cochrane Systematic Reviews, 19-Sep-2016
Vitrectomy surgery is one of the commonest ophthalmic procedures performed across the world. It may be performed using general or local anaesthesia encompassing regional or topical anaesthesia depending on a number of factors, including patient suitabilit
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