- Irinotecan chemotherapy combined with fluoropyrimidines versus irinotecan alone for overall survival and progression‐free survival in patients with advanced and/or metastatic colorectal cancer
Cochrane Systematic Reviews, 12-Feb-2016
Chemotherapy is the treatment of choice in patients with advanced or metastatic colorectal cancer (CRC) where surgical resection of metastases is not an option. Both irinotecan (IRI) and fluoropyrimidines are often included in first- or second- line chemo - Iron and folate supplementation in pregnancy
Cochrane Systematic Reviews, 20-Oct-2008
Anaemia in pregnancy is a major health problem in many developing countries where nutritional deficiency, malaria and other parasitic infections contribute to increased maternal and perinatal mortality and morbidity. - Iron chelators for acute stroke
Cochrane Systematic Reviews, 25-Nov-2020
Stroke is the second leading cause of death and a major cause of morbidity worldwide. Retrospective clinical and animal studies have demonstrated neuroprotective effects of iron chelators in people with haemorrhagic or ischaemic stroke. This is the first - Iron for the treatment of restless legs syndrome
Cochrane Systematic Reviews, 4-Jan-2019
Restless legs syndrome (RLS) is a common neurologic disorder that is associated with peripheral iron deficiency in a subgroup of patients. It is unclear whether iron therapy is effective treatment for RLS. - Iron supplementation for breath-holding attacks in children
Cochrane Systematic Reviews, 15-Jun-2010
Breath-holding attacks are common during childhood. Iron supplementation has been claimed to reduce the frequency or severity, or both, of breath-holding attacks in children. - Iron supplementation for reducing morbidity and mortality in children with HIV
Cochrane Systematic Reviews, 21-Jan-2009
This review will not be updated. It should be considered out of date. It has been superseded by this review: - Iron supplementation in pregnancy
Cochrane Systematic Reviews, 28-Oct-2008
Anaemia in pregnancy is a major health problem in many developing countries where nutritional deficiency, malaria and other parasitic infections contribute to increased maternal and perinatal mortality and morbidity. - Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia
Cochrane Systematic Reviews, 6-Jun-2013
Iron deficiency and iron deficiency anaemia (IDA) are common in young children. It has been suggested that the lack of iron may have deleterious effects on children's psychomotor development and cognitive function. To evaluate the benefits of iron therapy - Iron therapy for preoperative anaemia
Cochrane Systematic Reviews, 7-Dec-2019
Preoperative anaemia is common and occurs in 5% to 76% of patients preoperatively. It is associated with an increased risk of perioperative allogeneic blood transfusion, longer hospital stay, and increased morbidity and mortality. Iron deficiency is one o - Iron therapy in anaemic adults without chronic kidney disease
Cochrane Systematic Reviews, 30-Dec-2014
Anaemia affects about a quarter of the world's population. An estimated 50% of anaemic people have anaemia due to iron deficiency. - Iron‐chelating agents for treating malaria
Cochrane Systematic Reviews, 22-Apr-2003
It is still unclear whether iron-chelating agents, such as intravenous desferrioxamine (DFO) and oral deferiprone, given alone or added to standard antimalarial treatment would reduce malaria deaths. - Irrigants for non-surgical root canal treatment in mature permanent teeth
Cochrane Systematic Reviews, 8-Aug-2012
Root canal treatment is carried out on teeth in which irreversible pulpitis has led to necrosis of the dental pulp. As a treatment option it is an alternative to dental extraction. Mechanical preparation and irrigation with antiseptic or antibacterial sol - Ischaemic pre‐conditioning for elective liver resections performed under vascular occlusion
Cochrane Systematic Reviews, 21-Jan-2009
Vascular occlusion is used to reduce blood loss during liver resection surgery. The enzyme markers of liver injury are elevated if vascular occlusion is employed during liver resection. It is not clear whether ischaemic preconditioning prior to vascular o - Ischaemic preconditioning for liver transplantation
Cochrane Systematic Reviews, 23-Jan-2008
Ischaemic preconditioning is a mechanism for reducing organ ischaemia reperfusion injury by a brief period of organ ischaemia. - Ischaemic preconditioning for the reduction of renal ischaemia reperfusion injury
Cochrane Systematic Reviews, 4-Mar-2017
Ischaemia reperfusion injury can lead to kidney dysfunction or failure. Ischaemic preconditioning is a short period of deprivation of blood supply to particular organs or tissue, followed by a period of reperfusion. It has the potential to protect kidneys - Isocaloric balanced protein supplementation in pregnancy
Cochrane Systematic Reviews, 23-Oct-2008
Background pending. - Isoflavones for hypercholesterolaemia in adults
Cochrane Systematic Reviews, 16-May-2013
Hypercholesterolaemia is a significant risk factor for cardiovascular diseases. Isoflavones may be effective in improving hypercholesterolaemia. - Isolation as a strategy for controlling the transmission of hepatitis C virus (HCV) infection in haemodialysis units
Cochrane Systematic Reviews, 11-Aug-2016
The hepatitis C virus (HCV) infection affects about 2% of the world's population and can cause chronic liver infection and persistent long-term sequelae such as cirrhosis and liver cancer. - Isoniazid for preventing tuberculosis in HIV‐infected children
Cochrane Systematic Reviews, 29-Aug-2017
Tuberculosis (TB) is an important cause of illness and death in HIV-positive children living in areas of high TB prevalence. We know that isoniazid prophylaxis prevents TB in HIV-negative children following TB exposure, but there is uncertainty related to - Isoniazid for preventing tuberculosis in non‐HIV infected persons
Cochrane Systematic Reviews, 25-Jan-1999
Although isoniazid (INH) is commonly used for treating tuberculosis (TB), it is also effective as preventive therapy.
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