- Interventions for melanoma in situ, including lentigo maligna
Cochrane Systematic Reviews, 25-Jan-2016
Malignant melanoma is a form of skin cancer associated with significant mortality once it has spread beyond the skin. Melanoma in situ (MIS) is the earliest histologically recognisable stage of malignant melanoma and represents a precursor of invasive mel - Interventions for melasma
Cochrane Systematic Reviews, 14-Jun-2010
Melasma is an acquired symmetrical pigmentary disorder where confluent grey-brown patches typically appear on the face. Available treatments for melasma are unsatisfactory. - Interventions for men and women with their first episode of genital herpes
Cochrane Systematic Reviews, 18-Aug-2016
Genital herpes is incurable, and is caused by the herpes simplex virus (HSV). First-episode genital herpes is the first clinical presentation of herpes that a person experiences. Current treatment is based around viral suppression in order to decrease the - Interventions for metabolic bone disease in children with chronic kidney disease
Cochrane Systematic Reviews, 10-Nov-2015
Bone disease is common in children with chronic kidney disease (CKD) and when untreated may result in bone deformities, bone pain, fractures and reduced growth rates. This is an update of a review first published in 2010. - Interventions for minimal change disease in adults with nephrotic syndrome
Cochrane Systematic Reviews, 12-Aug-2009
Steroids have been used widely since the early 1970s for the treatment of adult-onset minimal change disease. The response rates to immunosuppressive agents in adult minimal change disease, especially steroids, are more variable than in children. The opti - Interventions for Mooren's ulcer
Cochrane Systematic Reviews, 9-Jan-2014
Mooren's ulcer is a chronic, painful peripheral ulcer of the cornea. Its cause is unknown but it can or will lead to loss of vision if untreated. Severe pain is common in patients with Mooren's ulcer and the eye(s) may be intensely reddened, inflamed and - Interventions for morphea
Cochrane Systematic Reviews, 15-Jul-2019
Morphea (morphoea) is an immune-mediated disease in which excess synthesis and deposition of collagen in the skin and underlying connective tissues results in hardened cutaneous areas. Morphea has different clinical features according to the subtype and s - Interventions for motor apraxia following stroke
Cochrane Systematic Reviews, 25-Aug-2008
Apraxia is a cognitive disorder that can occur after stroke. It prevents a person from carrying out a learned movement. Various interventions are used to treat apraxia but evidence of their benefit has been lacking. - Interventions for mucous membrane pemphigoid and epidermolysis bullosa acquisita
Cochrane Systematic Reviews, 7-Oct-2015
Mucous membrane pemphigoid and epidermolysis bullosa acquisita are rare acquired autoimmune blistering diseases of the skin. Both can result in scarring of mucous membranes which may lead to blindness and life threatening respiratory complications. - Interventions for mycosis fungoides
Cochrane Systematic Reviews, 4-Apr-2016
Mycosis fungoides is the most common type of cutaneous T-cell lymphoma, a malignant, chronic disease initially affecting the skin. Several therapies are available, which may induce clinical remission for a time. - Interventions for nail psoriasis
Cochrane Systematic Reviews, 11-Dec-2012
Psoriasis is a common skin disease that can also involve the nails. All parts of the nail and surrounding structures can become affected. The incidence of nail involvement increases with duration of psoriasis. Although it is difficult to treat psoriatic n - Interventions for nausea and vomiting in early pregnancy
Cochrane Systematic Reviews, 8-Sep-2015
Nausea, retching and vomiting are very commonly experienced by women in early pregnancy. There are considerable physical, social and psychological effects on women who experience these symptoms. This is an update of a review of interventions for nausea an - Interventions for necrotising pancreatitis
Cochrane Systematic Reviews, 12-Apr-2016
Acute necrotising pancreatitis carries significant mortality, morbidity, and resource use. There is considerable uncertainty as to how people with necrotising pancreatitis should be treated. - Interventions for necrotizing soft tissue infections in adults
Cochrane Systematic Reviews, 30-May-2018
Necrotizing soft tissue infections (NSTIs) are severe and rapidly spreading soft tissue infections of the subcutaneous tissue, fascia, or muscle, which are mostly caused by bacteria. Associated rates of mortality and morbidity are high, with the former es - Interventions for noisy breathing in patients near to death
Cochrane Systematic Reviews, 25-Apr-2017
This is an updated version of the original Cochrane review published in Issue 1, 2008. Noisy breathing (death rattle) occurs in 23 to 92% of people who are dying. The cause of noisy breathing remains unproven but is presumed to be due to an accumulation o - Interventions for non-metastatic squamous cell carcinoma of the skin
Cochrane Systematic Reviews, 2-Mar-2015
Squamous cell carcinoma (SCC) is the second most common skin cancer, and is becoming increasingly common around the world. Left untreated, it may spread to other parts of the body, and, although the risk is low, it may ultimately lead to death. Surgical e - Interventions for obtaining and maintaining employment in adults with severe mental illness, a network meta-analysis
Cochrane Systematic Reviews, 12-Sep-2017
People with severe mental illness show high rates of unemployment and work disability, however, they often have a desire to participate in employment. People with severe mental illness used to be placed in sheltered employment or were enrolled in prevocat - Interventions for Old World cutaneous leishmaniasis
Cochrane Systematic Reviews, 1-Dec-2017
Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, t - Interventions for orbital lymphangioma
Cochrane Systematic Reviews, 10-May-2019
Orbital lymphangiomas are a subset of localized vascular and lymphatic malformations, which most commonly occur in the head and neck region. Orbital lymphangiomas typically present in the first decade of life with signs of ptosis, proptosis, restriction o - Interventions for oropharyngeal dysphagia in children with neurological impairment
Cochrane Systematic Reviews, 11-Sep-2012
Oropharyngeal dysphagia encompasses problems with the oral preparatory phase of swallowing (chewing and preparing the food), oral phase (moving the food or fluid posteriorly through the oral cavity with the tongue into the back of the throat) and pharynge
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