- Interventions for atypical haemolytic uraemic syndrome
Cochrane Systematic Reviews, 30-Mar-2021
Atypical haemolytic uraemic syndrome (aHUS) is a rare disorder characterised by thrombocytopenia, microangiopathic haemolytic anaemia, and acute kidney injury. The condition is primarily caused by inherited or acquired dysregulation of complement regulato - Interventions for autumn exacerbations of asthma in children
Cochrane Systematic Reviews, 8-Mar-2018
Asthma exacerbations in school-aged children peak in autumn, shortly after children return to school following the summer holiday. This might reflect a combination of risk factors, including poor treatment adherence, increased allergen and viral exposure, - Interventions for bacterial folliculitis and boils (furuncles and carbuncles)
Cochrane Systematic Reviews, 26-Feb-2021
Bacterial folliculitis and boils are globally prevalent bacterial infections involving inflammation of the hair follicle and the perifollicular tissue. Some folliculitis may resolve spontaneously, but others may progress to boils without treatment. Boils, - Interventions for basal cell carcinoma of the skin
Cochrane Systematic Reviews, 17-Nov-2020
Basal cell carcinoma (BCC) is the commonest cancer affecting white-skinned individuals, and worldwide incidence is increasing. Although rarely fatal, BCC is associated with significant morbidity and costs. First-line treatment is usually surgical excision - Interventions for bronchiectasis: an overview of Cochrane systematic reviews
Cochrane Systematic Reviews, 14-Jul-2015
Bronchiectasis is a chronic respiratory disease characterised by abnormal dilatation of the bronchi, and presents typically with a chronic productive cough (or chronic wet cough in children) and recurrent infective exacerbations. It significantly impacts - Interventions for bullous pemphigoid
Cochrane Systematic Reviews, 6-Oct-2010
Bullous pemphigoid (BP) is the most common autoimmune blistering disease in the West. Oral steroids are the standard treatment.This is an update of the review published in 2005. - Interventions for cellulitis and erysipelas
Cochrane Systematic Reviews, 16-Jun-2010
Cellulitis and erysipelas are now usually considered manifestations of the same condition, a skin infection associated with severe pain and systemic symptoms. A range of antibiotic treatments are suggested in guidelines. - Interventions for central giant cell granuloma (CGCG) of the jaws
Cochrane Systematic Reviews, 7-Oct-2009
Central giant cell granuloma (CGCG) of the jaws is a rare benign tumour with an unknown aetiology accounting for up to 7% of tumours in the mandible (lower jaw) and the maxilla (upper jaw). - Interventions for central serous chorioretinopathy: a network meta‐analysis
Cochrane Systematic Reviews, 22-Dec-2015
Central serous chorioretinopathy (CSC) is characterized by serous detachment of the neural retina with dysfunction of the choroid and retinal pigment epithelium (RPE). The effects on the retina are usually self limited, although some people are left with - Interventions for childhood apraxia of speech
Cochrane Systematic Reviews, 30-May-2018
Childhood apraxia of speech (CAS) affects a child's ability to produce sounds and syllables precisely and consistently, and to produce words and sentences with accuracy and correct speech rhythm. It is a rare condition, affecting only 0.1% of the general - Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube) insertion
Cochrane Systematic Reviews, 14-Nov-2016
Ear discharge (otorrhoea) is common in children with grommets (ventilation/tympanostomy tubes); the proportion of children developing discharge ranges from 25% to 75%. The most common treatment strategies include oral broad-spectrum antibiotics, antibioti - Interventions for chronic abacterial prostatitis
Cochrane Systematic Reviews, 25-Oct-1999
Chronic abacterial prostatitis is a common disabling but enigmatic condition with a symptom complex of pelvic area pain and lower urinary tract symptoms. The scope of treatments recommended for chronic abacterial prostatitis is a testament to how little i - Interventions for chronic blepharitis
Cochrane Systematic Reviews, 19-Apr-2012
Blepharitis, an inflammatory condition associated with itchiness, redness, flaking, and crusting of the eyelids, is a common eye condition that affects both children and adults. It is common in all ethnic groups and across all ages. Although infrequent, b - Interventions for chronic kidney disease in people with sickle cell disease
Cochrane Systematic Reviews, 3-Jul-2017
Sickle cell disease (SCD) is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta-globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premat - Interventions for chronic kidney disease‐associated restless legs syndrome
Cochrane Systematic Reviews, 7-Nov-2016
Restless legs syndrome (RLS) is defined as the spontaneous movement of the limbs (mainly legs) associated with unpleasant, sometimes painful sensation which is relieved by moving the affected limb. Prevalence of RLS among people on dialysis has been estim - Interventions for chronic non‐hypovolaemic hypotonic hyponatraemia
Cochrane Systematic Reviews, 28-Jun-2018
Chronic (present > 48 hours) non-hypovolaemic hyponatraemia occurs frequently, can be caused by various conditions, and is associated with shorter survival and longer hospital stays. Many treatments, such as fluid restriction or vasopressin receptor antag - Interventions for chronic palmoplantar pustulosis
Cochrane Systematic Reviews, 25-Jan-2006
Chronic palmoplantar pustulosis (PPP) is a chronic inflammatory skin condition characterised by crops of sterile pustules (yellow pus spots) on the palms and soles which erupt repeatedly over months or years. The affected areas tend to become red and scal - Interventions for chronic palmoplantar pustulosis
Cochrane Systematic Reviews, 20-Jan-2020
Palmoplantar pustulosis is a chronic inflammatory disease in which sterile, relapsing pustules appear on the palms and soles, possibly in conjunction with other symptoms. The previous Cochrane Review on this topic was published in 2006, before biological - Interventions for chronic pruritus of unknown origin
Cochrane Systematic Reviews, 25-Jan-2020
Pruritus is a sensation that leads to the desire to scratch; its origin is unknown in 8% to 15% of affected patients. The prevalence of chronic pruritus of unknown origin (CPUO) in individuals with generalised pruritus ranges from 3.6% to 44.5%, with high - Interventions for chronic suppurative otitis media
Cochrane Systematic Reviews, 9-Nov-2008
Chronic suppurative otitis media (CSOM) is a serious bacterial infection of the middle ear that can follow untreated acute otitis media.
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