- Antipsychotics for treatment of delirium in hospitalised non-ICU patients
Cochrane Systematic Reviews, 15-Jun-2018
Guidelines suggest limited and cautious use of antipsychotics for treatment of delirium where nonpharmacological interventions have failed and symptoms remain distressing or dangerous, or both. It is unclear how well these recommendations are supported by - Antiretroviral interventions for preventing breast milk transmission of HIV
Cochrane Systematic Reviews, 28-Sep-2014
An estimated 260,000 children under the age of 15 years acquired HIV infection in 2012. As much as 42% of mother-to-child transmission is related to breastfeeding. Antiretroviral prophylaxis for mothers or infants has the potential to prevent mother-to-ch - Antiretroviral post-exposure prophylaxis (PEP) for occupational HIV exposure
Cochrane Systematic Reviews, 12-Apr-2012
Populations such as healthcare workers (HCWs), injection drug users (IDUs), and people engaging in unprotected sex are all at risk of being infected with the human immunodeficiency virus (HIV). Animal models show that after initial exposure, HIV replicate - Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals
Cochrane Systematic Reviews, 10-Nov-2012
More than 30 years into the global HIV/AIDS epidemic, infection rates remain alarmingly high, with over 2.7 million people becoming infected every year. There is a need for HIV prevention strategies that are more effective. Oral antiretroviral pre-exposur - Antiretroviral regimens for patients with HIV who fail first-line antiretroviral therapy
Cochrane Systematic Reviews, 19-Jan-2011
Highly active antiretroviral therapy has reduced the morbidity and mortality of patients with HIV/AIDS. A common first-line ART regimen in low-resource settings includes a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse t - Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women
Cochrane Systematic Reviews, 5-May-2010
This systematic review focuses on antiretroviral therapy (ART) for treating human immunodeficiency virus (HIV) infection in ART-eligible pregnant women. Mother-to-child transmission (MTCT) is the primary means by which children worldwide acquire HIV infec - Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples
Cochrane Systematic Reviews, 26-Mar-2013
Antiretroviral drugs have been shown to reduce risk of mother-to-child transmission of human immunodeficiency virus (HIV) and are also widely used for post-exposure prophylaxis for parenteral and sexual exposures. Sexual transmission may be lower in coupl - Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection
Cochrane Systematic Reviews, 13-Jun-2011
Antiretroviral drugs reduce viral replication and can reduce mother-to-child transmission of HIV either by lowering plasma viral load in pregnant women or through post-exposure prophylaxis in their newborns. In rich countries, highly active antiretroviral - Antiseptics for burns
Cochrane Systematic Reviews, 23-Nov-2017
Burn wounds cause high levels of morbidity and mortality worldwide. People with burns are particularly vulnerable to infections; over 75% of all burn deaths (after initial resuscitation) result from infection. Antiseptics are topical agents that act to pr - Antistreptococcal interventions for guttate and chronic plaque psoriasis
Cochrane Systematic Reviews, 4-Mar-2019
Psoriasis is a chronic skin disease that affects approximately two per cent of the general population. Plaque psoriasis is the most common form: it usually appears as raised, red patches of inflamed skin, covered with silvery white scales. The patches oft - Antistreptococcal interventions for guttate and chronic plaque psoriasis
Cochrane Systematic Reviews, 6-Mar-2019
Guttate psoriasis is a distinctive acute form of psoriasis which characteristically occurs in children and young adults. It is closely associated with preceding streptococcal sore throat or tonsillitis. Some authorities have claimed that ordinary (chronic - Antithrombin for respiratory distress syndrome in preterm infants
Cochrane Systematic Reviews, 24-Jan-2010
Acquired Antithrombin (AT) deficiency is a common and prognostically important finding in sick preterm infants with respiratory distress syndrome (RDS). It has been hypothesised that AT concentrate may improve clinical outcomes in preterm infants with RDS - Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants
Cochrane Systematic Reviews, 21-Mar-2016
Preterm birth remains the major risk factor for the development of intraventricular hemorrhage, an injury that occurs in 25% of very low birth weight infants. Intraventricular hemorrhage is thought to be venous in origin and intrinsic thromboses in the ge - Antithrombin III for critically ill patients
Cochrane Systematic Reviews, 13-Dec-2018
Critical illness is associated with uncontrolled inflammation and vascular damage which can result in multiple organ failure and death. Antithrombin III (AT III) is an anticoagulant with anti-inflammatory properties but the efficacy and any harmful effect - Antithrombotic drugs for carotid artery dissection
Cochrane Systematic Reviews, 6-Mar-2011
Extracranial internal carotid artery dissection (eICAD) is a leading cause of stroke in younger patients. - Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction
Cochrane Systematic Reviews, 17-Jul-2013
Pregnancy complications such as pre-eclampsia and eclampsia, intrauterine growth restriction and placental abruption are thought to have a common origin related to abnormalities in the development and function of the placenta. - Anti-tuberculous therapy for maintenance of remission in Crohn's disease
Cochrane Systematic Reviews, 21-Jul-2016
There have been a number of studies with conflicting results which have examined the effect of anti-tuberculous therapy in Crohn's disease. A meta-analysis was performed to evaluate the use of anti-tuberculous therapy for the maintenance of remission in C - Anti-tumour necrosis factor biological therapies for the treatment of uveitic macular oedema (UMO) for non-infectious uveitis
Cochrane Systematic Reviews, 27-Nov-2018
Non-infectious uveitis describes a heterogenous group of ocular disorders characterised by intraocular inflammation in the absence of infection. Uveitis is a leading cause of visual loss, most commonly due to uveitic macular oedema (UMO). Treatment is aim - Anti-vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity
Cochrane Systematic Reviews, 7-Jan-2018
Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis in foetal life. Researchers have recently attempted to use anti-VEGF agents for the treatment of retinopathy of prematurity (ROP), a vasoproliferative disorder. The safety and effi - Anti-vascular endothelial growth factor for choroidal neovascularisation in people with pathological myopia
Cochrane Systematic Reviews, 15-Dec-2016
Choroidal neovascularisation (CNV) is a common complication of pathological myopia. Once developed, most eyes with myopic CNV (mCNV) experience a progression to macular atrophy, which leads to irreversible vision loss. Anti-vascular endothelial growth fac
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