- Inhaled corticosteroids for cystic fibrosis
Cochrane Systematic Reviews, 4-Jul-2019
The reduction of lung inflammation is one of the goals of cystic fibrosis therapy. Inhaled corticosteroids are often used in this respect to treat children and adults with cystic fibrosis. The rationale for this is their potential to reduce lung damage ar - Inhaled corticosteroids for non-specific chronic cough in children
Cochrane Systematic Reviews, 29-Mar-2009
Cough in isolation of other clinical features is known as non-specific cough, which has been defined as non-productive cough in the absence of identifiable respiratory disease or any known aetiology. In children with non-specific cough the possibility of - Inhaled corticosteroids for stable chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 25-Aug-2016
The role of inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD) has been the subject of much controversy. Major international guidelines recommend selective use of ICS. Recently published meta-analyses have reported conflicting f - Inhaled corticosteroids for subacute and chronic cough in adults
Cochrane Systematic Reviews, 11-Apr-2013
Persistent cough is a common clinical problem. Despite thorough investigation and empirical management, a considerable proportion of those people with subacute and chronic cough have unexplained cough, for which treatment options are limited. While curren - Inhaled corticosteroids for subacute cough in children
Cochrane Systematic Reviews, 11-Dec-2012
Cough is the most common symptom presenting to primary healthcare services. Cough in children is associated with significant morbidity for both children and their parents. While inhaled corticosteroids (ICS) can potentially reduce cough associated with ai - Inhaled corticosteroids in children with persistent asthma: dose-response effects on growth
Cochrane Systematic Reviews, 28-Jan-2016
Inhaled corticosteroids (ICS) are the first-line treatment for children with persistent asthma. Their potential for growth suppression remains a matter of concern for parents and physicians. - Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth
Cochrane Systematic Reviews, 10-Jun-2019
Inhaled corticosteroids (ICS) are the most effective treatment for children with persistent asthma. Although treatment with ICS is generally considered to be safe in children, the potential adverse effects of these drugs on growth remains a matter of conc - Inhaled corticosteroids in children with persistent asthma: effects on growth
Cochrane Systematic Reviews, 16-Jun-2014
Treatment guidelines for asthma recommend inhaled corticosteroids (ICS) as first-line therapy for children with persistent asthma. Although ICS treatment is generally considered safe in children, the potential systemic adverse effects related to regular u - Inhaled corticosteroids versus long-acting beta2-agonists for chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 25-Apr-2018
Long-acting beta2-agonists and inhaled corticosteroids can be used as maintenance therapy by patients with moderate to severe chronic obstructive pulmonary disease. These interventions are often taken together in a combination inhaler. However, the relati - Inhaled cromones for prolonged non-specific cough in children
Cochrane Systematic Reviews, 20-Jul-2010
Non-specific cough is defined as non-productive cough in the absence of identifiable respiratory disease or known aetiology. It is commonly seen in paediatric practice. These children are treated with a variety of therapies including inhaled cromones. - Inhaled hyperosmolar agents for bronchiectasis
Cochrane Systematic Reviews, 9-May-2014
Mucus retention in the lungs is a prominent feature of bronchiectasis. The stagnant mucus becomes chronically colonised with bacteria, which elicit a host neutrophilic response. This fails to eliminate the bacteria, and the large concentration of host-der - Inhaled insulin in diabetes mellitus
Cochrane Systematic Reviews, 8-Oct-2008
Insulin therapy often relies on multiple daily injections of insulin. However this is a considerable burden to many people with diabetes and adherence to such an insulin regimen can be difficult to maintain, hence compromising optimal glycaemic control. A - Inhaled magnesium sulfate in the treatment of acute asthma
Cochrane Systematic Reviews, 28-Nov-2017
Asthma exacerbations can be frequent and range in severity from mild to life-threatening. The use of magnesium sulfate (MgSO4) is one of numerous treatment options available during acute exacerbations. While the efficacy of intravenous MgSO4 has been demo - Inhaled mannitol for cystic fibrosis
Cochrane Systematic Reviews, 12-Jan-2018
Several agents are used to clear secretions from the airways of people with cystic fibrosis. Mannitol increases mucociliary clearance, but its exact mechanism of action is unknown. The dry powder formulation of mannitol may be more convenient and easier t - Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease
Cochrane Systematic Reviews, 24-Jan-2013
Acute chest syndrome has been defined as a new infiltrate visible on chest radiograph associated with one or more symptoms, such as fever, cough, sputum production, tachypnoea, dyspnoea, or new-onset hypoxia. Symptoms and complications of this syndrome, w - Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults
Cochrane Systematic Reviews, 12-Dec-2018
Acute hypoxaemic respiratory failure (AHRF) and mostly acute respiratory distress syndrome (ARDS) are critical conditions. AHRF results from several systemic conditions and is associated with high mortality and morbidity in individuals of all ages. Inhale - Inhaled nitric oxide for respiratory failure in preterm infants
Cochrane Systematic Reviews, 23-Dec-2016
Inhaled nitric oxide (iNO) is effective in term infants with hypoxic respiratory failure. The pathophysiology of respiratory failure and the potential risks of iNO differ substantially in preterm infants, necessitating specific study in this population. - Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease
Cochrane Systematic Reviews, 3-Jul-2014
Nitric oxide (NO) is a prevalent molecule in humans that is responsible for many physiologic activities including pulmonary vasodilation. An exogenous, inhaled form (iNO) exists that mimics this action without affecting systemic blood pressure. This thera - Inhaled nitric oxide for treating pain crises in people with sickle cell disease
Cochrane Systematic Reviews, 10-Oct-2019
In people with sickle cell disease, sickled red blood cells cause the occlusion of small blood vessels which presents as episodes of severe pain known as pain crises or vaso-occlusive crises. The pain can occur in the bones, chest, or other parts of the b - Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis
Cochrane Systematic Reviews, 21-Jan-2016
Chronic neutrophilic inflammation, in both the presence and absence of infection, is a feature of bronchiectasis in adults and children. The anti-inflammatory properties of non-steroid anti-inflammatory drugs (NSAIDs) may be beneficial in reducing airway
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